Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1266719..1267196 Replicon chromosome
Accession NZ_CP026957
Organism Staphylococcus aureus strain FDAARGOS_43

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RL01_RS06730 Protein ID WP_000052076.1
Coordinates 1267008..1267196 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RL01_RS06725 Protein ID WP_001059690.1
Coordinates 1266719..1266979 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL01_RS06690 1262114..1262830 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
RL01_RS06695 1262978..1263400 + 423 WP_000974464.1 organic hydroperoxide resistance protein -
RL01_RS06700 1263799..1264293 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RL01_RS06705 1264448..1265065 + 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
RL01_RS06710 1265138..1265719 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
RL01_RS06715 1265943..1266179 + 237 WP_000368687.1 hypothetical protein -
RL01_RS06720 1266176..1266379 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RL01_RS06725 1266719..1266979 + 261 WP_001059690.1 hypothetical protein Antitoxin
RL01_RS06730 1267008..1267196 + 189 WP_000052076.1 hypothetical protein Toxin
RL01_RS06735 1267384..1267953 + 570 WP_001106654.1 hypothetical protein -
RL01_RS06740 1268041..1268325 + 285 WP_001004401.1 hypothetical protein -
RL01_RS06745 1268387..1268605 + 219 WP_000005886.1 hypothetical protein -
RL01_RS06750 1269101..1269301 - 201 WP_001059082.1 cold-shock protein -
RL01_RS06755 1269658..1270344 - 687 WP_001793574.1 thermonuclease family protein -
RL01_RS06760 1270685..1271206 - 522 WP_000824464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - vWbp / vWbp / clfA / sell / sec 1263799..1295025 31226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T96804 WP_000052076.1 NZ_CP026957:1267008-1267196 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96804 NZ_CP026957:1267008-1267196 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96804 WP_001059690.1 NZ_CP026957:1266719-1266979 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96804 NZ_CP026957:1266719-1266979 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References