20378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2951498..2953683 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name HipA2 Uniprot ID Q9A4U2
Locus tag CC_RS14270 Protein ID WP_010920579.1
Coordinates 2951498..2952832 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag CC_RS14275 Protein ID WP_010920580.1
Coordinates 2952829..2953683 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC_RS14245 (CC_2731) 2947557..2947928 - 372 WP_010920575.1 hypothetical protein -
CC_RS14250 2947999..2948202 - 204 WP_024265842.1 hypothetical protein -
CC_RS14255 2948881..2948994 + 114 WP_012640570.1 hypothetical protein -
CC_RS14260 (CC_2733) 2949220..2949375 - 156 WP_012640571.1 hypothetical protein -
CC_RS14265 (CC_2734) 2949385..2951274 + 1890 WP_010920578.1 pilus assembly protein TadG -
CC_RS14270 (CC_2735) 2951498..2952832 - 1335 WP_010920579.1 type II toxin-antitoxin system HipA family toxin Toxin
CC_RS14275 (CC_2736) 2952829..2953683 - 855 WP_010920580.1 helix-turn-helix transcriptional regulator Antitoxin
CC_RS14280 2953690..2953836 - 147 WP_024265843.1 hypothetical protein -
CC_RS14285 2953932..2954057 - 126 WP_012640572.1 hypothetical protein -
CC_RS14290 (CC_2738) 2954242..2954595 + 354 WP_010920582.1 hypothetical protein -
CC_RS14295 (CC_2739) 2954585..2954998 + 414 Protein_2803 IS6 family transposase -
CC_RS14300 (CC_2740) 2955129..2956151 + 1023 WP_012640573.1 IS110-like element ISCc4 family transposase -
CC_RS14305 (CC_2742) 2956276..2957462 + 1187 WP_096053990.1 IS3-like element IS511 family transposase -
CC_RS14310 (CC_2743) 2957434..2958618 + 1185 WP_010920585.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2941644..2956542 14898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(225-279)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48396.41 Da        Isoelectric Point: 5.2025

>T20378 WP_010920579.1 NC_002696:c2952832-2951498 [Caulobacter vibrioides CB15]
MSGPAGLIVRMDGFNLPAGYLASDEARAISFAYDDRYIAAGGPPLSLSMPLEQVSFGDVTARAFFDNLLPENDQMQRVMD
REGLARDDIVGLLSHLGADCSGAISCLPIGADPIKVPGVLSEDYELLAPGAIAEIARSLAERQRLPDTITDPSPVAGVQR
KIALTHTPQGFAKPRPGRKVPTTHILKVPETRLRRDARLEAAAARLASALGLDVSIPEAIVIDGVDALLITRFDRVVRDG
VVYRLHQEDFAQAMGLPATLKYQRNGAPGRQFDAQAIARVLDQTEAPALSRTAFLSATIFNLLIGNTDNHAKNHGLLYRQ
GRAPILAPLYDLLPSRMNLDFNDQLSFNIGAADHPDAITFDDMMAFFEVFGMRRAAAARFIENVIKPMIEALERATLGLA
GERLKDMDDLIGRETEQLVEVLGLDVAVRERDYYPKVRHALAPS

Download         Length: 1335 bp

>T20378 NC_002696:c2952832-2951498 [Caulobacter vibrioides CB15]
ATGAGTGGGCCCGCAGGCCTGATCGTCCGCATGGACGGTTTTAATCTACCTGCTGGCTACCTCGCGTCGGACGAGGCGCG
GGCCATCAGCTTCGCTTACGACGACCGTTACATTGCTGCGGGCGGGCCGCCTTTGTCGCTATCCATGCCGCTTGAACAGG
TAAGCTTCGGCGATGTGACAGCGCGGGCCTTTTTCGACAACCTTCTCCCTGAAAACGATCAGATGCAGCGGGTGATGGAT
CGTGAGGGGCTGGCGCGGGACGATATCGTCGGCCTGTTAAGCCATCTAGGGGCTGACTGCTCAGGAGCGATTTCCTGTCT
GCCGATTGGCGCTGATCCCATCAAGGTTCCCGGCGTGTTGTCGGAGGACTACGAATTGCTGGCGCCGGGCGCCATCGCGG
AAATCGCCCGCAGTCTCGCCGAGCGTCAACGCCTTCCCGACACCATAACCGATCCATCCCCGGTCGCCGGAGTCCAGCGC
AAGATTGCTTTGACCCATACCCCTCAGGGGTTCGCCAAGCCTAGGCCGGGCCGCAAGGTGCCCACCACTCATATTCTAAA
GGTGCCTGAGACACGGCTGCGCCGCGATGCTCGTTTGGAGGCCGCCGCCGCGAGGTTGGCCAGTGCTCTTGGTCTGGACG
TGTCGATCCCCGAGGCCATTGTCATTGATGGCGTGGATGCTTTGCTAATCACACGTTTTGATCGAGTGGTGCGAGACGGC
GTGGTCTACCGCCTTCATCAGGAAGACTTTGCTCAGGCTATGGGGTTGCCTGCGACTTTGAAGTATCAGCGTAACGGAGC
GCCCGGTCGGCAGTTTGACGCGCAGGCCATCGCGCGCGTCCTTGACCAAACGGAGGCGCCTGCGCTGTCGCGCACGGCCT
TTCTGTCGGCGACGATCTTCAATCTTCTGATTGGCAATACTGACAACCACGCCAAGAACCATGGATTGCTCTACCGGCAA
GGTCGGGCTCCGATTCTCGCGCCGCTCTACGACCTGCTGCCCAGTCGCATGAATCTGGATTTCAATGACCAGCTGTCTTT
CAACATCGGCGCGGCTGATCACCCCGATGCGATCACCTTTGATGACATGATGGCGTTTTTTGAGGTGTTCGGCATGAGGC
GAGCGGCGGCGGCGCGCTTCATCGAAAACGTCATCAAACCCATGATCGAGGCGTTGGAACGCGCCACCTTGGGGTTGGCG
GGCGAGCGCCTCAAGGACATGGACGACCTAATCGGTCGGGAAACCGAGCAACTCGTCGAAGTGTTGGGTCTGGATGTCGC
TGTCCGCGAGAGAGACTATTACCCCAAGGTCCGCCACGCCTTGGCGCCGAGTTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 28530.71 Da        Isoelectric Point: 10.0342

>AT20378 WP_010920580.1 NC_002696:c2953683-2952829 [Caulobacter vibrioides CB15]
MLLSGSENVSDDNKGKLGIGREASVPSAADLLKRAMGGSLARDALKIAGVSGATSELLASIGRIGVASDALKMAGITSVA
SDALKIAGVGAASDALRVVSAGGLKPEFLASIGKISAASDALKLASVTSAADILKNADVGRLNAIAPPSISLASAAGGAR
QGGELSPLSDILDATRHLTNERYAVTAPSPSAADSLKQTDGGAQYNLPIARMQVPQPIKSPRALGQLVRQARERMGLTQA
AFADAAGVGRRFVSELENGKPTLELGKVMAVCAAAGLDLMAAPR

Download         Length: 855 bp

>AT20378 NC_002696:c2953683-2952829 [Caulobacter vibrioides CB15]
ATGCTCCTGAGCGGGAGCGAAAACGTGTCTGACGATAACAAAGGAAAGCTCGGCATTGGTCGTGAGGCGAGCGTGCCTAG
TGCTGCTGACCTGCTCAAGCGCGCCATGGGAGGTTCACTCGCCCGTGACGCCCTGAAAATCGCAGGCGTTAGTGGCGCGA
CGTCCGAACTCCTGGCGTCCATCGGTAGGATCGGCGTCGCGTCCGACGCACTGAAGATGGCCGGGATTACGTCCGTGGCC
AGCGATGCGTTGAAAATCGCAGGTGTTGGCGCTGCATCCGACGCCTTGAGGGTCGTCAGCGCCGGTGGGTTAAAGCCTGA
GTTTCTGGCGTCCATCGGTAAAATCAGCGCCGCTTCCGATGCGCTCAAGCTTGCTAGCGTCACCTCTGCCGCCGACATTC
TCAAGAACGCGGACGTGGGGCGATTGAACGCTATCGCGCCTCCGTCGATCAGTTTGGCCAGCGCCGCGGGTGGCGCGCGT
CAGGGGGGGGAATTATCGCCCCTAAGCGACATTCTGGACGCAACGCGTCACCTGACCAACGAGCGCTACGCCGTGACCGC
CCCATCGCCGAGTGCGGCCGACAGCCTCAAGCAGACCGACGGGGGGGCGCAGTACAACCTGCCCATAGCGCGCATGCAGG
TGCCGCAGCCGATCAAGTCGCCGCGAGCTTTGGGTCAACTGGTCCGCCAGGCGCGCGAAAGGATGGGTTTAACCCAAGCG
GCTTTCGCTGACGCCGCAGGCGTCGGGCGTCGGTTCGTGTCGGAGCTTGAAAACGGCAAGCCGACCTTGGAGCTGGGCAA
GGTGATGGCCGTCTGCGCTGCGGCCGGCCTAGATCTGATGGCGGCGCCCAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9A4U2

Antitoxin

Source ID Structure

References