80727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3071611..3073796 Replicon chromosome
Accession NZ_CP023314
Organism Caulobacter vibrioides strain CB1

Toxin (Protein)


Gene name HipA2 Uniprot ID Q9A4U2
Locus tag CA607_RS15015 Protein ID WP_010920579.1
Coordinates 3071611..3072945 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag CA607_RS15020 Protein ID WP_010920580.1
Coordinates 3072942..3073796 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA607_RS14990 3067670..3068041 - 372 WP_010920575.1 hypothetical protein -
CA607_RS20695 3068112..3068315 - 204 WP_024265842.1 hypothetical protein -
CA607_RS15000 3068994..3069107 + 114 WP_012640570.1 hypothetical protein -
CA607_RS15005 3069333..3069488 - 156 WP_012640571.1 hypothetical protein -
CA607_RS15010 3069498..3071387 + 1890 WP_010920578.1 pilus assembly protein TadG -
CA607_RS15015 3071611..3072945 - 1335 WP_010920579.1 type II toxin-antitoxin system HipA family toxin Toxin
CA607_RS15020 3072942..3073796 - 855 WP_010920580.1 helix-turn-helix transcriptional regulator Antitoxin
CA607_RS15025 3073803..3073949 - 147 WP_024265843.1 hypothetical protein -
CA607_RS20700 3074045..3074170 - 126 WP_012640572.1 hypothetical protein -
CA607_RS15035 3074355..3074708 + 354 WP_010920582.1 hypothetical protein -
CA607_RS15040 3074698..3075111 + 414 Protein_2918 IS6 family transposase -
CA607_RS15045 3075242..3076264 + 1023 WP_012640573.1 IS110-like element ISCc4 family transposase -
CA607_RS15050 3076389..3077575 + 1187 WP_096053990.1 IS3-like element IS511 family transposase -
CA607_RS15055 3077547..3078731 + 1185 WP_010920585.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3061757..3076655 14898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(225-279)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48396.41 Da        Isoelectric Point: 5.2025

>T80727 WP_010920579.1 NZ_CP023314:c3072945-3071611 [Caulobacter vibrioides]
MSGPAGLIVRMDGFNLPAGYLASDEARAISFAYDDRYIAAGGPPLSLSMPLEQVSFGDVTARAFFDNLLPENDQMQRVMD
REGLARDDIVGLLSHLGADCSGAISCLPIGADPIKVPGVLSEDYELLAPGAIAEIARSLAERQRLPDTITDPSPVAGVQR
KIALTHTPQGFAKPRPGRKVPTTHILKVPETRLRRDARLEAAAARLASALGLDVSIPEAIVIDGVDALLITRFDRVVRDG
VVYRLHQEDFAQAMGLPATLKYQRNGAPGRQFDAQAIARVLDQTEAPALSRTAFLSATIFNLLIGNTDNHAKNHGLLYRQ
GRAPILAPLYDLLPSRMNLDFNDQLSFNIGAADHPDAITFDDMMAFFEVFGMRRAAAARFIENVIKPMIEALERATLGLA
GERLKDMDDLIGRETEQLVEVLGLDVAVRERDYYPKVRHALAPS

Download         Length: 1335 bp

>T80727 NZ_CP023314:c3072945-3071611 [Caulobacter vibrioides]
ATGAGTGGGCCCGCAGGCCTGATCGTCCGCATGGACGGTTTTAATCTACCTGCTGGCTACCTCGCGTCGGACGAGGCGCG
GGCCATCAGCTTCGCTTACGACGACCGTTACATTGCTGCGGGCGGGCCGCCTTTGTCGCTATCCATGCCGCTTGAACAGG
TAAGCTTCGGCGATGTGACAGCGCGGGCCTTTTTCGACAACCTTCTCCCTGAAAACGATCAGATGCAGCGGGTGATGGAT
CGTGAGGGGCTGGCGCGGGACGATATCGTCGGCCTGTTAAGCCATCTAGGGGCTGACTGCTCAGGAGCGATTTCCTGTCT
GCCGATTGGCGCTGATCCCATCAAGGTTCCCGGCGTGTTGTCGGAGGACTACGAATTGCTGGCGCCGGGCGCCATCGCGG
AAATCGCCCGCAGTCTCGCCGAGCGTCAACGCCTTCCCGACACCATAACCGATCCATCCCCGGTCGCCGGAGTCCAGCGC
AAGATTGCTTTGACCCATACCCCTCAGGGGTTCGCCAAGCCTAGGCCGGGCCGCAAGGTGCCCACCACTCATATTCTAAA
GGTGCCTGAGACACGGCTGCGCCGCGATGCTCGTTTGGAGGCCGCCGCCGCGAGGTTGGCCAGTGCTCTTGGTCTGGACG
TGTCGATCCCCGAGGCCATTGTCATTGATGGCGTGGATGCTTTGCTAATCACACGTTTTGATCGAGTGGTGCGAGACGGC
GTGGTCTACCGCCTTCATCAGGAAGACTTTGCTCAGGCTATGGGGTTGCCTGCGACTTTGAAGTATCAGCGTAACGGAGC
GCCCGGTCGGCAGTTTGACGCGCAGGCCATCGCGCGCGTCCTTGACCAAACGGAGGCGCCTGCGCTGTCGCGCACGGCCT
TTCTGTCGGCGACGATCTTCAATCTTCTGATTGGCAATACTGACAACCACGCCAAGAACCATGGATTGCTCTACCGGCAA
GGTCGGGCTCCGATTCTCGCGCCGCTCTACGACCTGCTGCCCAGTCGCATGAATCTGGATTTCAATGACCAGCTGTCTTT
CAACATCGGCGCGGCTGATCACCCCGATGCGATCACCTTTGATGACATGATGGCGTTTTTTGAGGTGTTCGGCATGAGGC
GAGCGGCGGCGGCGCGCTTCATCGAAAACGTCATCAAACCCATGATCGAGGCGTTGGAACGCGCCACCTTGGGGTTGGCG
GGCGAGCGCCTCAAGGACATGGACGACCTAATCGGTCGGGAAACCGAGCAACTCGTCGAAGTGTTGGGTCTGGATGTCGC
TGTCCGCGAGAGAGACTATTACCCCAAGGTCCGCCACGCCTTGGCGCCGAGTTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 28530.71 Da        Isoelectric Point: 10.0342

>AT80727 WP_010920580.1 NZ_CP023314:c3073796-3072942 [Caulobacter vibrioides]
MLLSGSENVSDDNKGKLGIGREASVPSAADLLKRAMGGSLARDALKIAGVSGATSELLASIGRIGVASDALKMAGITSVA
SDALKIAGVGAASDALRVVSAGGLKPEFLASIGKISAASDALKLASVTSAADILKNADVGRLNAIAPPSISLASAAGGAR
QGGELSPLSDILDATRHLTNERYAVTAPSPSAADSLKQTDGGAQYNLPIARMQVPQPIKSPRALGQLVRQARERMGLTQA
AFADAAGVGRRFVSELENGKPTLELGKVMAVCAAAGLDLMAAPR

Download         Length: 855 bp

>AT80727 NZ_CP023314:c3073796-3072942 [Caulobacter vibrioides]
ATGCTCCTGAGCGGGAGCGAAAACGTGTCTGACGATAACAAAGGAAAGCTCGGCATTGGTCGTGAGGCGAGCGTGCCTAG
TGCTGCTGACCTGCTCAAGCGCGCCATGGGAGGTTCACTCGCCCGTGACGCCCTGAAAATCGCAGGCGTTAGTGGCGCGA
CGTCCGAACTCCTGGCGTCCATCGGTAGGATCGGCGTCGCGTCCGACGCACTGAAGATGGCCGGGATTACGTCCGTGGCC
AGCGATGCGTTGAAAATCGCAGGTGTTGGCGCTGCATCCGACGCCTTGAGGGTCGTCAGCGCCGGTGGGTTAAAGCCTGA
GTTTCTGGCGTCCATCGGTAAAATCAGCGCCGCTTCCGATGCGCTCAAGCTTGCTAGCGTCACCTCTGCCGCCGACATTC
TCAAGAACGCGGACGTGGGGCGATTGAACGCTATCGCGCCTCCGTCGATCAGTTTGGCCAGCGCCGCGGGTGGCGCGCGT
CAGGGGGGGGAATTATCGCCCCTAAGCGACATTCTGGACGCAACGCGTCACCTGACCAACGAGCGCTACGCCGTGACCGC
CCCATCGCCGAGTGCGGCCGACAGCCTCAAGCAGACCGACGGGGGGGCGCAGTACAACCTGCCCATAGCGCGCATGCAGG
TGCCGCAGCCGATCAAGTCGCCGCGAGCTTTGGGTCAACTGGTCCGCCAGGCGCGCGAAAGGATGGGTTTAACCCAAGCG
GCTTTCGCTGACGCCGCAGGCGTCGGGCGTCGGTTCGTGTCGGAGCTTGAAAACGGCAAGCCGACCTTGGAGCTGGGCAA
GGTGATGGCCGTCTGCGCTGCGGCCGGCCTAGATCTGATGGCGGCGCCCAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9A4U2

Antitoxin

Source ID Structure

References