115296

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2973459..2975644 Replicon chromosome
Accession NZ_CP034122
Organism Caulobacter vibrioides strain CB2A

Toxin (Protein)


Gene name HipA2 Uniprot ID Q9A4U2
Locus tag EIB18_RS14500 Protein ID WP_010920579.1
Coordinates 2973459..2974793 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag EIB18_RS14505 Protein ID WP_010920580.1
Coordinates 2974790..2975644 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIB18_RS14475 2969518..2969889 - 372 WP_010920575.1 hypothetical protein -
EIB18_RS20090 2969960..2970163 - 204 WP_024265842.1 hypothetical protein -
EIB18_RS14485 2970842..2970955 + 114 WP_012640570.1 hypothetical protein -
EIB18_RS14490 2971181..2971336 - 156 WP_012640571.1 hypothetical protein -
EIB18_RS14495 2971346..2973235 + 1890 WP_010920578.1 pilus assembly protein TadG -
EIB18_RS14500 2973459..2974793 - 1335 WP_010920579.1 type II toxin-antitoxin system HipA family toxin Toxin
EIB18_RS14505 2974790..2975644 - 855 WP_010920580.1 helix-turn-helix transcriptional regulator Antitoxin
EIB18_RS14510 2975651..2975797 - 147 WP_024265843.1 hypothetical protein -
EIB18_RS20095 2975893..2976018 - 126 WP_012640572.1 hypothetical protein -
EIB18_RS14520 2976203..2976556 + 354 WP_010920582.1 hypothetical protein -
EIB18_RS14525 2976546..2976959 + 414 Protein_2805 IS6 family transposase -
EIB18_RS14530 2977090..2978112 + 1023 WP_012640573.1 IS110-like element ISCc4 family transposase -
EIB18_RS14535 2978237..2979423 + 1187 WP_096053990.1 IS3-like element IS511 family transposase -
EIB18_RS14540 2979395..2980579 + 1185 WP_010920585.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2963605..2978503 14898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(225-279)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48396.41 Da        Isoelectric Point: 5.2025

>T115296 WP_010920579.1 NZ_CP034122:c2974793-2973459 [Caulobacter vibrioides]
MSGPAGLIVRMDGFNLPAGYLASDEARAISFAYDDRYIAAGGPPLSLSMPLEQVSFGDVTARAFFDNLLPENDQMQRVMD
REGLARDDIVGLLSHLGADCSGAISCLPIGADPIKVPGVLSEDYELLAPGAIAEIARSLAERQRLPDTITDPSPVAGVQR
KIALTHTPQGFAKPRPGRKVPTTHILKVPETRLRRDARLEAAAARLASALGLDVSIPEAIVIDGVDALLITRFDRVVRDG
VVYRLHQEDFAQAMGLPATLKYQRNGAPGRQFDAQAIARVLDQTEAPALSRTAFLSATIFNLLIGNTDNHAKNHGLLYRQ
GRAPILAPLYDLLPSRMNLDFNDQLSFNIGAADHPDAITFDDMMAFFEVFGMRRAAAARFIENVIKPMIEALERATLGLA
GERLKDMDDLIGRETEQLVEVLGLDVAVRERDYYPKVRHALAPS

Download         Length: 1335 bp

>T115296 NZ_CP034122:c2974793-2973459 [Caulobacter vibrioides]
ATGAGTGGGCCCGCAGGCCTGATCGTCCGCATGGACGGTTTTAATCTACCTGCTGGCTACCTCGCGTCGGACGAGGCGCG
GGCCATCAGCTTCGCTTACGACGACCGTTACATTGCTGCGGGCGGGCCGCCTTTGTCGCTATCCATGCCGCTTGAACAGG
TAAGCTTCGGCGATGTGACAGCGCGGGCCTTTTTCGACAACCTTCTCCCTGAAAACGATCAGATGCAGCGGGTGATGGAT
CGTGAGGGGCTGGCGCGGGACGATATCGTCGGCCTGTTAAGCCATCTAGGGGCTGACTGCTCAGGAGCGATTTCCTGTCT
GCCGATTGGCGCTGATCCCATCAAGGTTCCCGGCGTGTTGTCGGAGGACTACGAATTGCTGGCGCCGGGCGCCATCGCGG
AAATCGCCCGCAGTCTCGCCGAGCGTCAACGCCTTCCCGACACCATAACCGATCCATCCCCGGTCGCCGGAGTCCAGCGC
AAGATTGCTTTGACCCATACCCCTCAGGGGTTCGCCAAGCCTAGGCCGGGCCGCAAGGTGCCCACCACTCATATTCTAAA
GGTGCCTGAGACACGGCTGCGCCGCGATGCTCGTTTGGAGGCCGCCGCCGCGAGGTTGGCCAGTGCTCTTGGTCTGGACG
TGTCGATCCCCGAGGCCATTGTCATTGATGGCGTGGATGCTTTGCTAATCACACGTTTTGATCGAGTGGTGCGAGACGGC
GTGGTCTACCGCCTTCATCAGGAAGACTTTGCTCAGGCTATGGGGTTGCCTGCGACTTTGAAGTATCAGCGTAACGGAGC
GCCCGGTCGGCAGTTTGACGCGCAGGCCATCGCGCGCGTCCTTGACCAAACGGAGGCGCCTGCGCTGTCGCGCACGGCCT
TTCTGTCGGCGACGATCTTCAATCTTCTGATTGGCAATACTGACAACCACGCCAAGAACCATGGATTGCTCTACCGGCAA
GGTCGGGCTCCGATTCTCGCGCCGCTCTACGACCTGCTGCCCAGTCGCATGAATCTGGATTTCAATGACCAGCTGTCTTT
CAACATCGGCGCGGCTGATCACCCCGATGCGATCACCTTTGATGACATGATGGCGTTTTTTGAGGTGTTCGGCATGAGGC
GAGCGGCGGCGGCGCGCTTCATCGAAAACGTCATCAAACCCATGATCGAGGCGTTGGAACGCGCCACCTTGGGGTTGGCG
GGCGAGCGCCTCAAGGACATGGACGACCTAATCGGTCGGGAAACCGAGCAACTCGTCGAAGTGTTGGGTCTGGATGTCGC
TGTCCGCGAGAGAGACTATTACCCCAAGGTCCGCCACGCCTTGGCGCCGAGTTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 28530.71 Da        Isoelectric Point: 10.0342

>AT115296 WP_010920580.1 NZ_CP034122:c2975644-2974790 [Caulobacter vibrioides]
MLLSGSENVSDDNKGKLGIGREASVPSAADLLKRAMGGSLARDALKIAGVSGATSELLASIGRIGVASDALKMAGITSVA
SDALKIAGVGAASDALRVVSAGGLKPEFLASIGKISAASDALKLASVTSAADILKNADVGRLNAIAPPSISLASAAGGAR
QGGELSPLSDILDATRHLTNERYAVTAPSPSAADSLKQTDGGAQYNLPIARMQVPQPIKSPRALGQLVRQARERMGLTQA
AFADAAGVGRRFVSELENGKPTLELGKVMAVCAAAGLDLMAAPR

Download         Length: 855 bp

>AT115296 NZ_CP034122:c2975644-2974790 [Caulobacter vibrioides]
ATGCTCCTGAGCGGGAGCGAAAACGTGTCTGACGATAACAAAGGAAAGCTCGGCATTGGTCGTGAGGCGAGCGTGCCTAG
TGCTGCTGACCTGCTCAAGCGCGCCATGGGAGGTTCACTCGCCCGTGACGCCCTGAAAATCGCAGGCGTTAGTGGCGCGA
CGTCCGAACTCCTGGCGTCCATCGGTAGGATCGGCGTCGCGTCCGACGCACTGAAGATGGCCGGGATTACGTCCGTGGCC
AGCGATGCGTTGAAAATCGCAGGTGTTGGCGCTGCATCCGACGCCTTGAGGGTCGTCAGCGCCGGTGGGTTAAAGCCTGA
GTTTCTGGCGTCCATCGGTAAAATCAGCGCCGCTTCCGATGCGCTCAAGCTTGCTAGCGTCACCTCTGCCGCCGACATTC
TCAAGAACGCGGACGTGGGGCGATTGAACGCTATCGCGCCTCCGTCGATCAGTTTGGCCAGCGCCGCGGGTGGCGCGCGT
CAGGGGGGGGAATTATCGCCCCTAAGCGACATTCTGGACGCAACGCGTCACCTGACCAACGAGCGCTACGCCGTGACCGC
CCCATCGCCGAGTGCGGCCGACAGCCTCAAGCAGACCGACGGGGGGGCGCAGTACAACCTGCCCATAGCGCGCATGCAGG
TGCCGCAGCCGATCAAGTCGCCGCGAGCTTTGGGTCAACTGGTCCGCCAGGCGCGCGAAAGGATGGGTTTAACCCAAGCG
GCTTTCGCTGACGCCGCAGGCGTCGGGCGTCGGTTCGTGTCGGAGCTTGAAAACGGCAAGCCGACCTTGGAGCTGGGCAA
GGTGATGGCCGTCTGCGCTGCGGCCGGCCTAGATCTGATGGCGGCGCCCAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9A4U2

Antitoxin

Source ID Structure

References