Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/RHH-MazF |
| Location | 54803..55353 | Replicon | chromosome |
| Accession | NC_002655 | ||
| Organism | Escherichia coli O157:H7 str. EDL933 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | D3H432 |
| Locus tag | Z_RS00275 | Protein ID | WP_001160975.1 |
| Coordinates | 55039..55353 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | V0VEX8 |
| Locus tag | Z_RS00270 | Protein ID | WP_000125566.1 |
| Coordinates | 54803..55036 (+) | Length | 78 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Z_RS00245 (Z0050) | 49877..50164 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
| Z_RS00250 (Z0051) | 50222..51553 | + | 1332 | WP_001183177.1 | MFS transporter | - |
| Z_RS00255 (Z0052) | 51661..52191 | + | 531 | WP_000600700.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
| Z_RS00260 (Z0053) | 52184..54046 | + | 1863 | WP_000377197.1 | glutathione-regulated potassium-efflux system protein KefC | - |
| Z_RS00265 (Z0055) | 54238..54717 | + | 480 | WP_000624372.1 | type 3 dihydrofolate reductase | - |
| Z_RS00270 (Z0056) | 54803..55036 | + | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| Z_RS00275 (Z0057) | 55039..55353 | + | 315 | WP_001160975.1 | CcdB family protein | Toxin |
| Z_RS00280 (Z0058) | 55350..56198 | - | 849 | WP_000257187.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
| Z_RS00285 (Z0059) | 56205..56582 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
| Z_RS00290 (Z0060) | 56585..57406 | - | 822 | WP_001065380.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
| Z_RS00295 (Z0061) | 57403..58392 | - | 990 | WP_000241259.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
| Z_RS00300 (Z0062) | 58392..59678 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.76 Da Isoelectric Point: 9.8517
>T190 WP_001160975.1 NC_002655:55039-55353 [Escherichia coli O157:H7 str. EDL933]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T190 NC_002655:55039-55353 [Escherichia coli O157:H7 str. EDL933]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT190 WP_000125566.1 NC_002655:54803-55036 [Escherichia coli O157:H7 str. EDL933]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT190 NC_002655:54803-55036 [Escherichia coli O157:H7 str. EDL933]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10018 | Escherichia coli O157:H7 str. Sakai |
100 |
100 |
1 |
| T10099 | Escherichia coli Nissle 1917 |
98.077 |
100 |
0.981 |
| T10064 | Dickeya dadantii 3937 |
47.573 |
100 |
0.48 |
| T6145 | Escherichia coli K-12 |
35.577 |
100 |
0.366 |
| T6109 | uncultured bacterium |
35.577 |
100 |
0.366 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10099 | Escherichia coli Nissle 1917 |
100 |
100 |
1 |
| AT10018 | Escherichia coli O157:H7 str. Sakai |
100 |
100 |
1 |
| AT10064 | Dickeya dadantii 3937 |
43.421 |
98.701 |
0.429 |
Multiple sequence alignment
References
(1) Myriam Wilbaux et al. (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. Journal of Bacteriology 189(7):2712-9. [PubMed:17259320]
(2) Kritika Gupta et al. (2017) Contribution of the Chromosomal ccdAB Operon to Bacterial Drug Tolerance. Journal of Bacteriology 199(19):e00397-17. [PubMed:28674066]