Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-phd/HigB(toxin)
Location 389042..389492 Replicon chromosome
Accession NZ_CP053803
Organism Vibrio cholerae strain L6G

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HPY16_RS14765 Protein ID WP_175248422.1
Coordinates 389205..389492 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HPY16_RS14760 Protein ID WP_175248421.1
Coordinates 389042..389164 (+) Length 41 a.a.

Genomic Context

HPY16_RS14705HPY16_RS14710HPY16_RS14715HPY16_RS14720HPY16_RS14725HPY16_RS14730HPY16_RS14735HPY16_RS14740HPY16_RS14745HPY16_RS14750HPY16_RS14755HPY16_RS14760HPY16_RS14765HPY16_RS14770HPY16_RS14775HPY16_RS14780HPY16_RS14785HPY16_RS14790HPY16_RS14795HPY16_RS14800HPY16_RS14805
Location: 384207..384440 (234 bp)
Type: Others
Protein ID: WP_175248420.1
Location: 384484..384921 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 384981..385280 (300 bp)
Type: Others
Protein ID: Protein_389
Location: 385487..385777 (291 bp)
Type: Others
Protein ID: WP_080536237.1
Location: 385802..385921 (120 bp)
Type: Others
Protein ID: WP_020977912.1
Location: 385958..386497 (540 bp)
Type: Others
Protein ID: WP_175231429.1
Location: 386649..387224 (576 bp)
Type: Others
Protein ID: WP_094129300.1
Location: 387265..387342 (78 bp)
Type: Others
Protein ID: WP_175248608.1
Location: 387492..387723 (232 bp)
Type: Others
Protein ID: Protein_395
Location: 387910..388197 (288 bp)
Type: Others
Protein ID: WP_000654672.1
Location: 388328..389035 (708 bp)
Type: Others
Protein ID: WP_057562218.1
Location: 389042..389164 (123 bp)
Type: Antitoxin
Protein ID: WP_175248421.1
Location: 389205..389492 (288 bp)
Type: Toxin
Protein ID: WP_175248422.1
Location: 389503..389820 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 389967..390476 (510 bp)
Type: Others
Protein ID: WP_002053638.1
Location: 390595..391257 (663 bp)
Type: Others
Protein ID: WP_000084914.1
Location: 391424..392449 (1026 bp)
Type: Others
Protein ID: WP_175231413.1
Location: 392445..392567 (123 bp)
Type: Others
Protein ID: WP_175231869.1
Location: 392603..393019 (417 bp)
Type: Others
Protein ID: WP_175248423.1
Location: 393196..394083 (888 bp)
Type: Others
Protein ID: WP_175248424.1
Location: 394108..394201 (94 bp)
Type: Others
Protein ID: Protein_407
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HPY16_RS14705384207..384440+234WP_175248420.1hypothetical protein-
HPY16_RS14710384484..384921+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
HPY16_RS14715384981..385280+300Protein_389GNAT family N-acetyltransferase-
HPY16_RS14720385487..385777+291WP_080536237.1YkgJ family cysteine cluster protein-
HPY16_RS14725385802..385921+120WP_020977912.1DUF3265 domain-containing protein-
HPY16_RS14730385958..386497+540WP_175231429.1hydrolase-
HPY16_RS14735386649..387224+576WP_094129300.1hypothetical protein-
HPY16_RS14740387265..387342+78WP_175248608.1hypothetical protein-
HPY16_RS14745387492..387723+232Protein_395DUF645 family protein-
HPY16_RS14750387910..388197+288WP_000654672.1hypothetical protein-
HPY16_RS14755388328..389035+708WP_057562218.1HAD family hydrolase-
HPY16_RS14760389042..389164+123WP_175248421.1acetyltransferaseAntitoxin
HPY16_RS14765389205..389492+288WP_175248422.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HPY16_RS14770389503..389820+318WP_001232701.1HigA family addiction module antidote protein-
HPY16_RS14775389967..390476+510WP_002053638.1GNAT family N-acetyltransferase-
HPY16_RS14780390595..391257+663WP_000084914.1Vat family streptogramin A O-acetyltransferase-
HPY16_RS14785391424..392449+1026WP_175231413.1hypothetical protein-
HPY16_RS14790392445..392567+123WP_175231869.1DUF3265 domain-containing protein-
HPY16_RS14795392603..393019+417WP_175248423.1ASCH domain-containing protein-
HPY16_RS14800393196..394083+888WP_175248424.1FRG domain-containing protein-
HPY16_RS14805394108..394201+94Protein_407DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandblaCARB-7-309435..510278200843
-insideIntegron--310548..509407198859
flankIS/Tn--384484..384921437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11322.92 Da        Isoelectric Point: 6.7187

>T157924 WP_175248422.1 NZ_CP053803:389205-389492 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGSLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T157924 NZ_CP069517:c1111541-1111263 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 41 a.a.        Molecular weight: 4646.83 Da        Isoelectric Point: 12.1021

>AT157924 WP_175248421.1 NZ_CP053803:389042-389164 [Vibrio cholerae]
VVSVVVIKFSVMRCQPLRRALCTFLKSFLQIKLVHSVIMR

Download         Length: 123 bp

>AT157924 NZ_CP069517:c1111263-1110979 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References