144545

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 3204695..3205232 Replicon chromosome
Accession NZ_CP046583
Organism Burkholderia pseudomallei strain B03

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag GN245_RS14485 Protein ID WP_004549731.1
Coordinates 3204963..3205232 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag GN245_RS14480 Protein ID WP_004525420.1
Coordinates 3204695..3204979 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN245_RS14455 3199803..3201065 - 1263 WP_004530738.1 c-type cytochrome -
GN245_RS14460 3201224..3202684 - 1461 WP_044583952.1 metallophosphoesterase -
GN245_RS14465 3202931..3203047 + 117 Protein_2612 IS3 family transposase -
GN245_RS14470 3203274..3203702 - 429 Protein_2613 IS110 family transposase -
GN245_RS14475 3203665..3204048 - 384 Protein_2614 DDE-type integrase/transposase/recombinase -
GN245_RS14480 3204695..3204979 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
GN245_RS14485 3204963..3205232 - 270 WP_004549731.1 BrnT family toxin Toxin
GN245_RS14490 3205803..3206078 + 276 WP_038759296.1 hypothetical protein -
GN245_RS14495 3206088..3206219 + 132 WP_009923452.1 bacteriophage protein Gp48 -
GN245_RS14505 3206355..3206576 + 222 WP_038759295.1 hypothetical protein -
GN245_RS34390 3206543..3206842 + 300 WP_161788725.1 hypothetical protein -
GN245_RS14515 3207073..3207654 - 582 Protein_2621 hypothetical protein -
GN245_RS14520 3207910..3208059 + 150 WP_004537646.1 bacteriophage protein Gp44 -
GN245_RS34395 3208056..3208829 + 774 Protein_2623 prohibitin family protein -
GN245_RS34400 3208827..3209255 + 429 Protein_2624 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3197583..3231163 33580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T144545 WP_004549731.1 NZ_CP046583:c3205232-3204963 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T144545 NZ_CP062146:3779796-3780182 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT144545 WP_004525420.1 NZ_CP046583:c3204979-3204695 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT144545 NZ_CP062146:3780175-3780495 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References