Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2558298..2558500 Replicon chromosome
Accession NZ_CP042267
Organism Clostridioides difficile strain Mta-79

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag FQN08_RS12300 Protein ID WP_004454589.1
Coordinates 2558348..2558500 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2558298..2558427 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQN08_RS12265 2553424..2553741 + 318 WP_004454574.1 hypothetical protein -
FQN08_RS12270 2553877..2554341 + 465 WP_032508861.1 hypothetical protein -
FQN08_RS12280 2554670..2554831 - 162 WP_004454578.1 hypothetical protein -
FQN08_RS19290 2554883..2555697 - 815 Protein_2295 toxin Bro -
FQN08_RS19295 2555818..2556006 - 189 WP_004454585.1 hypothetical protein -
FQN08_RS12295 2557247..2558154 - 908 Protein_2297 SHOCT domain-containing protein -
- 2558298..2558427 + 130 NuclAT_1 - Antitoxin
FQN08_RS12300 2558348..2558500 - 153 WP_004454589.1 hypothetical protein Toxin
FQN08_RS12305 2558773..2559096 - 324 WP_009897482.1 hypothetical protein -
FQN08_RS12310 2559132..2559386 - 255 WP_004454592.1 hypothetical protein -
FQN08_RS12320 2559826..2560344 - 519 Protein_2301 transposase -
FQN08_RS12325 2560634..2561009 - 376 Protein_2302 BlaI/MecI/CopY family transcriptional regulator -
FQN08_RS12330 2561114..2561491 - 378 WP_011861518.1 BlaI/MecI/CopY family transcriptional regulator -
FQN08_RS12335 2562295..2562789 + 495 WP_011861519.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
FQN08_RS12340 2563178..2563348 + 171 WP_004454601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2551603..2568597 16994


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T135127 WP_004454589.1 NZ_CP042267:c2558500-2558348 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T135127 NZ_CP042267:c2558500-2558348 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT135127 NZ_CP042267:2558298-2558427 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References