Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/RHH-PIN |
| Location | 3183138..3183825 | Replicon | chromosome |
| Accession | NC_000962 | ||
| Organism | Mycobacterium tuberculosis H37Rv | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF55 |
| Locus tag | Rv2872 | Protein ID | NP_217388.1 |
| Coordinates | 3183382..3183825 (+) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WL41 |
| Locus tag | Rv2871 | Protein ID | NP_217387.1 |
| Coordinates | 3183138..3183395 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Rv2867c | 3178458..3179312 | - | 855 | NP_217383.1 | GCN5-like N-acetyltransferase | - |
| Rv2868c | 3179368..3180531 | - | 1164 | NP_217384.1 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) | - |
| Rv2869c | 3180548..3181762 | - | 1215 | NP_217385.1 | zinc metalloprotease | - |
| Rv2870c | 3181770..3183011 | - | 1242 | NP_217386.2 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
| Rv2871 | 3183138..3183395 | + | 258 | NP_217387.1 | antitoxin VapB43 | Antitoxin |
| Rv2872 | 3183382..3183825 | + | 444 | NP_217388.1 | ribonuclease VapC43 | Toxin |
| Rv2873 | 3183905..3184567 | + | 663 | NP_217389.1 | cell surface lipoprotein | - |
| Rv2874 | 3184847..3186934 | + | 2088 | NP_217390.1 | integral membrane C-type cytochrome biogenesis protein DipZ | - |
| Rv2875 | 3187030..3187611 | + | 582 | NP_217391.1 | major secreted immunogenic protein Mpt70 | - |
| Rv2876 | 3187663..3187977 | + | 315 | NP_217392.1 | transmembrane protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16595.72 Da Isoelectric Point: 6.4890
>T125 NP_217388.1 NC_000962:3183382-3183825 [Mycobacterium tuberculosis H37Rv]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL
Download Length: 444 bp
>T125 NC_000962:3183382-3183825 [Mycobacterium tuberculosis H37Rv]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9013.22 Da Isoelectric Point: 10.8344
>AT125 NP_217387.1 NC_000962:3183138-3183395 [Mycobacterium tuberculosis H37Rv]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR
Download Length: 258 bp
>AT125 NC_000962:3183138-3183395 [Mycobacterium tuberculosis H37Rv]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T87 | Mycobacterium tuberculosis H37Rv |
40.714 |
98.592 |
0.401 |
| T111 | Mycobacterium tuberculosis H37Rv |
32.857 |
97.222 |
0.319 |
| T92 | Mycobacterium tuberculosis H37Rv |
31.206 |
98.601 |
0.308 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT87 | Mycobacterium tuberculosis H37Rv |
35.294 |
100 |
0.353 |
| AT92 | Mycobacterium tuberculosis H37Rv |
35.294 |
100 |
0.353 |
Multiple sequence alignment
References
(1) Holly R Ramage et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genetics 5(12):e1000767. [PubMed:20011113]
(2) Xiaoyu Wang et al. (2018) Mycobacterium tuberculosis toxin Rv2872 is an RNase involved in vancomycin stress response and biofilm development. Applied Microbiology And Biotechnology 102(16):7123-7133. [PubMed:29948114]