122603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 42874..43138 Replicon plasmid pGM351-2
Accession NZ_CP038417
Organism Escherichia coli O157:H7 strain 3-5-1

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag E4U90_RS27310 Protein ID WP_001331364.1
Coordinates 42986..43138 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 42874..42931 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U90_RS27295 38113..40404 - 2292 WP_001289276.1 hypothetical protein -
E4U90_RS27300 40397..41467 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
E4U90_RS27305 41486..42694 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 42874..42931 - 58 NuclAT_0 - Antitoxin
- 42874..42931 - 58 NuclAT_0 - Antitoxin
- 42874..42931 - 58 NuclAT_0 - Antitoxin
- 42874..42931 - 58 NuclAT_0 - Antitoxin
E4U90_RS27310 42986..43138 + 153 WP_001331364.1 Hok/Gef family protein Toxin
E4U90_RS27315 43210..43461 - 252 WP_001291964.1 hypothetical protein -
E4U90_RS27320 44120..44296 - 177 WP_001054897.1 hypothetical protein -
E4U90_RS27325 44688..44897 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
E4U90_RS27330 44969..45619 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
E4U90_RS27335 45693..47861 - 2169 WP_001774191.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - - 1..89216 89216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T122603 WP_001331364.1 NZ_CP038417:42986-43138 [Escherichia coli O157:H7]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T122603 NZ_CP038417:42986-43138 [Escherichia coli O157:H7]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT122603 NZ_CP038417:c42931-42874 [Escherichia coli O157:H7]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References