Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1691890..1692092 Replicon chromosome
Accession NZ_CP029566
Organism Clostridioides difficile strain CBA7204

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag DF008_RS07915 Protein ID WP_004454589.1
Coordinates 1691940..1692092 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 1691890..1692019 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DF008_RS07890 1687194..1687658 + 465 WP_025782691.1 hypothetical protein -
DF008_RS07895 1687987..1688148 - 162 WP_004454578.1 hypothetical protein -
DF008_RS07900 1688200..1688652 - 453 WP_201449208.1 hypothetical protein -
DF008_RS07905 1688649..1689014 - 366 WP_016729316.1 Bro-N domain-containing protein -
DF008_RS18560 1689135..1689287 - 153 WP_009897477.1 hypothetical protein -
DF008_RS07910 1690823..1691746 - 924 WP_011861517.1 SHOCT domain-containing protein -
- 1691890..1692019 + 130 NuclAT_3 - Antitoxin
DF008_RS07915 1691940..1692092 - 153 WP_004454589.1 hypothetical protein Toxin
DF008_RS07920 1692366..1692689 - 324 WP_009897482.1 hypothetical protein -
DF008_RS07925 1692725..1692979 - 255 WP_159376477.1 hypothetical protein -
DF008_RS07935 1693419..1693937 - 519 Protein_1554 transposase -
DF008_RS07940 1694220..1694595 - 376 Protein_1555 BlaI/MecI/CopY family transcriptional regulator -
DF008_RS07945 1694700..1695077 - 378 WP_095905896.1 BlaI/MecI/CopY family transcriptional regulator -
DF008_RS07950 1695882..1696376 + 495 WP_021422415.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
DF008_RS07955 1696765..1696935 + 171 WP_004454601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1684921..1700686 15765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T105787 WP_004454589.1 NZ_CP029566:c1692092-1691940 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T105787 NZ_CP029566:c1692092-1691940 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT105787 NZ_CP029566:1691890-1692019 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References