Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2627884..2628086 Replicon chromosome
Accession NZ_CP028361
Organism Clostridioides difficile strain DSM 105001

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag DSM105001_RS12530 Protein ID WP_004454589.1
Coordinates 2627934..2628086 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2627884..2628013 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM105001_RS12500 2623133..2623450 + 318 WP_009897465.1 hypothetical protein -
DSM105001_RS12505 2623586..2624050 + 465 WP_004454576.1 hypothetical protein -
DSM105001_RS12510 2624379..2624540 - 162 WP_004454578.1 hypothetical protein -
DSM105001_RS12515 2624592..2625406 - 815 Protein_2387 toxin Bro -
DSM105001_RS12520 2625526..2625678 - 153 WP_009897477.1 hypothetical protein -
DSM105001_RS12525 2626817..2627740 - 924 WP_021364626.1 SHOCT domain-containing protein -
- 2627884..2628013 + 130 NuclAT_3 - Antitoxin
DSM105001_RS12530 2627934..2628086 - 153 WP_004454589.1 hypothetical protein Toxin
DSM105001_RS12535 2628360..2628683 - 324 WP_021364628.1 hypothetical protein -
DSM105001_RS12540 2628719..2628973 - 255 WP_004454592.1 hypothetical protein -
DSM105001_RS12545 2629405..2629923 - 519 Protein_2393 transposase -
DSM105001_RS12550 2630213..2630587 - 375 Protein_2394 BlaI/MecI/CopY family transcriptional regulator -
DSM105001_RS12555 2630692..2631069 - 378 WP_021364350.1 BlaI/MecI/CopY family transcriptional regulator -
DSM105001_RS12560 2631874..2632368 + 495 WP_021364347.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
DSM105001_RS12565 2632757..2632927 + 171 WP_021416406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2621312..2638176 16864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T101036 WP_004454589.1 NZ_CP028361:c2628086-2627934 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T101036 NZ_CP028361:c2628086-2627934 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT101036 NZ_CP028361:2627884-2628013 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References