Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | yobL-yobK/- |
Location | 2066519..2068789 | Replicon | chromosome |
Accession | NZ_CP034484 | ||
Organism | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
Toxin (Protein)
Gene name | yobL | Uniprot ID | O34330 |
Locus tag | EJJ34_RS10455 | Protein ID | WP_004399481.1 |
Coordinates | 2066987..2068789 (-) | Length | 601 a.a. |
Antitoxin (Protein)
Gene name | yobK | Uniprot ID | G4EVG5 |
Locus tag | EJJ34_RS10450 | Protein ID | WP_003231326.1 |
Coordinates | 2066519..2066977 (-) | Length | 153 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EJJ34_RS10435 (EJJ34_10440) | 2064495..2064827 | - | 333 | WP_026009814.1 | hypothetical protein | - |
EJJ34_RS22930 | 2065116..2065208 | + | 93 | WP_109789044.1 | type I toxin-antitoxin system toxin BsrE | - |
EJJ34_RS10445 (EJJ34_10450) | 2065477..2066319 | - | 843 | WP_003231327.1 | hypothetical protein | - |
EJJ34_RS10450 (EJJ34_10455) | 2066519..2066977 | - | 459 | WP_003231326.1 | type VII secretion system immunity protein YobK | Antitoxin |
EJJ34_RS10455 (EJJ34_10460) | 2066987..2068789 | - | 1803 | WP_004399481.1 | LXG family T7SS effector ribonuclease toxin YobL | Toxin |
EJJ34_RS10460 (EJJ34_10465) | 2068891..2069448 | - | 558 | WP_004399321.1 | SMI1/KNR4 family protein | - |
EJJ34_RS10465 (EJJ34_10470) | 2069576..2071012 | + | 1437 | WP_004399325.1 | flavin monoamine oxidase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 601 a.a. Molecular weight: 88471.15 Da Isoelectric Point: 5.5500
>T10062 WP_004399481.1 NZ_CP034484:c2068789-2066987 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSEFSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSS
MSATLEDAKMSDAYIEESFLEHELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK
LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKKGDIEKHSEAYLSVKKEEAKERE
IKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQLAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFI
TDPGETLSALGNAAMHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKADAAGKVINK
ASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAKKIPDGTRKPFTGQKKSPPWLNKEKYDAYEI
EGKVKAKGKVKDVSRRVYTMKDIDINQKTEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDV
IHQLKSDGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN
MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSEFSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSS
MSATLEDAKMSDAYIEESFLEHELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK
LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKKGDIEKHSEAYLSVKKEEAKERE
IKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQLAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFI
TDPGETLSALGNAAMHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKADAAGKVINK
ASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAKKIPDGTRKPFTGQKKSPPWLNKEKYDAYEI
EGKVKAKGKVKDVSRRVYTMKDIDINQKTEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDV
IHQLKSDGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN
Download Length: 1803 bp
>T10062 NZ_CP034484:c2068789-2066987 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGAAGGTATTTGAGGCTGATTCATTACTCTTTGAAGCGGATAAAAGAACCAAAGAGTATAAGGAACTAAGGTCGCAAAT
GGTGAAGCTCAAAAAAGCGTTTAAGGAAGTAGCTAACCTAGATGACAGTGAATTTTCAGGCAAGGGTGCTGACAACATTA
AAGCATTTTATCATGGTCATGTCGGCGTAACAGACCAATGGATTGATCTTATCGATATGAAGATTGCTTTCTTAAGCAGC
ATGTCTGCAACACTTGAAGATGCGAAGATGTCTGATGCTTACATAGAAGAATCCTTTCTAGAACACGAGTTGGCTAACGC
TTATGCAAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCAATGAAAGACATATTAAACAACATCAATGATATCCTTC
CCCTTGAAATATTCTCAACAGAAGACTTCAAAGACAAACTTTCTTCTGCAGATGACAAACGTGAAAAAACAATCGATAAG
CTAAACAAGCTTGATGAGGATTTAAAAACAGAATACGCTGAAACAGAACCAAACGAACAATTTATTCAGCAAGACTTTAA
AAAGCTGCAGGAATCAACAGGCAAAGGAAAAAACGCTACACCAATTCACTATAACGCTAAAGCGTACAGAGAAAGTGACA
TACATAAGAAAAAAGGCGATATTGAAAAGCATTCTGAAGCTTACTTAAGTGTGAAGAAAGAAGAAGCAAAGGAACGTGAA
ATCAAGGAATTAAAGAAAAAACTTAATGACGGTGTATCTGACCCTGATGAATATTTAGAGATTGCTAAGAAAGTAGGGTA
CGAGAATCTGGAGCCAACTCAAGTGCAGCTTGCAGTGCAAATTGAACAAGCGAAGCAGCTAGAAGGAGCAGGAGAAATCA
CCTGGGATATCGTAAAAGGTGTAGGAGTTGGTTTATACGATGTAGGAAAAGACACTGTAACCGGCATATGGGACTTCATC
ACCGATCCAGGAGAAACACTCTCAGCACTGGGTAATGCAGCTATGCATCCAGTGAAAACATACGATGCCATTTCAGCAGC
AATAGAAGAGTCATATCAAAAGGATATGGTGAATGGAGATGCCTATTCTAGATCAAGATGGGTTACCTATGCTATTGGTT
CAGTGGCTGTAGCTGTTGTTGGTACAAAAGGTGCAGGAGCCATTAACAAAGCAGATGCAGCGGGCAAGGTAATAAATAAA
GCAAGTCAAGCAGGTAAGAAAATCAAGGACGTTAAGATTCCAGATTTGCTGCCTTACAACCCTAAGTATAAGCTTGCTCT
AGCAGATAACGTGCCATACAATGTGGTTGATAGCCAAAACCTTAAGAATGAACTTTTGACTAATGCGAAGAAAATACCGG
ATGGAACAAGAAAACCGTTTACTGGCCAAAAGAAAAGCCCTCCTTGGCTAAATAAAGAAAAGTATGATGCATATGAAATA
GAGGGGAAGGTAAAGGCGAAGGGGAAAGTTAAAGATGTAAGCCGTAGAGTGTATACTATGAAAGATATTGATATTAATCA
AAAAACAGAATTCGGTGTTACAAATCTTCAGCTAATGAAAAACGGGAATGCCCCTTATGCAAAAGACGGTACACAGATTA
ATTTACATCACTTGATTCAAGAAGAACCTGGCCCAATGCTTGAAATCCCGAACAGCTTACATACAAAATATAGTGATGTC
ATTCATCAGCTTAAGTCTGATGGTGAAAGTTTTAGAAATGATAAGGTTTTAAAAGCACAATACGAGAGCTTTAGAAAGAG
ATATTGGAAATGGAGAGCGAAACAATTTGAAAATGAGAATTGA
ATGAAGGTATTTGAGGCTGATTCATTACTCTTTGAAGCGGATAAAAGAACCAAAGAGTATAAGGAACTAAGGTCGCAAAT
GGTGAAGCTCAAAAAAGCGTTTAAGGAAGTAGCTAACCTAGATGACAGTGAATTTTCAGGCAAGGGTGCTGACAACATTA
AAGCATTTTATCATGGTCATGTCGGCGTAACAGACCAATGGATTGATCTTATCGATATGAAGATTGCTTTCTTAAGCAGC
ATGTCTGCAACACTTGAAGATGCGAAGATGTCTGATGCTTACATAGAAGAATCCTTTCTAGAACACGAGTTGGCTAACGC
TTATGCAAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCAATGAAAGACATATTAAACAACATCAATGATATCCTTC
CCCTTGAAATATTCTCAACAGAAGACTTCAAAGACAAACTTTCTTCTGCAGATGACAAACGTGAAAAAACAATCGATAAG
CTAAACAAGCTTGATGAGGATTTAAAAACAGAATACGCTGAAACAGAACCAAACGAACAATTTATTCAGCAAGACTTTAA
AAAGCTGCAGGAATCAACAGGCAAAGGAAAAAACGCTACACCAATTCACTATAACGCTAAAGCGTACAGAGAAAGTGACA
TACATAAGAAAAAAGGCGATATTGAAAAGCATTCTGAAGCTTACTTAAGTGTGAAGAAAGAAGAAGCAAAGGAACGTGAA
ATCAAGGAATTAAAGAAAAAACTTAATGACGGTGTATCTGACCCTGATGAATATTTAGAGATTGCTAAGAAAGTAGGGTA
CGAGAATCTGGAGCCAACTCAAGTGCAGCTTGCAGTGCAAATTGAACAAGCGAAGCAGCTAGAAGGAGCAGGAGAAATCA
CCTGGGATATCGTAAAAGGTGTAGGAGTTGGTTTATACGATGTAGGAAAAGACACTGTAACCGGCATATGGGACTTCATC
ACCGATCCAGGAGAAACACTCTCAGCACTGGGTAATGCAGCTATGCATCCAGTGAAAACATACGATGCCATTTCAGCAGC
AATAGAAGAGTCATATCAAAAGGATATGGTGAATGGAGATGCCTATTCTAGATCAAGATGGGTTACCTATGCTATTGGTT
CAGTGGCTGTAGCTGTTGTTGGTACAAAAGGTGCAGGAGCCATTAACAAAGCAGATGCAGCGGGCAAGGTAATAAATAAA
GCAAGTCAAGCAGGTAAGAAAATCAAGGACGTTAAGATTCCAGATTTGCTGCCTTACAACCCTAAGTATAAGCTTGCTCT
AGCAGATAACGTGCCATACAATGTGGTTGATAGCCAAAACCTTAAGAATGAACTTTTGACTAATGCGAAGAAAATACCGG
ATGGAACAAGAAAACCGTTTACTGGCCAAAAGAAAAGCCCTCCTTGGCTAAATAAAGAAAAGTATGATGCATATGAAATA
GAGGGGAAGGTAAAGGCGAAGGGGAAAGTTAAAGATGTAAGCCGTAGAGTGTATACTATGAAAGATATTGATATTAATCA
AAAAACAGAATTCGGTGTTACAAATCTTCAGCTAATGAAAAACGGGAATGCCCCTTATGCAAAAGACGGTACACAGATTA
ATTTACATCACTTGATTCAAGAAGAACCTGGCCCAATGCTTGAAATCCCGAACAGCTTACATACAAAATATAGTGATGTC
ATTCATCAGCTTAAGTCTGATGGTGAAAGTTTTAGAAATGATAAGGTTTTAAAAGCACAATACGAGAGCTTTAGAAAGAG
ATATTGGAAATGGAGAGCGAAACAATTTGAAAATGAGAATTGA
Antitoxin
Download Length: 153 a.a. Molecular weight: 22536.04 Da Isoelectric Point: 5.5500
>AT10062 WP_003231326.1 NZ_CP034484:c2066977-2066519 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYKWFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEH
YGLTDGLVVIEDVDYFAYCLDTNKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD
MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYKWFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEH
YGLTDGLVVIEDVDYFAYCLDTNKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD
Download Length: 459 bp
>AT10062 NZ_CP034484:c2066977-2066519 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGATTTATTCGAAGGTTGAGAACTTTATTAATGAAAATAAACAAAATGCTATATTTACAGAAGGTGCAAGTCATGAAAA
CATTGGTCGCATTGAAGAAAACCTCCAATGCGATCTCCCCAACAGTTATAAATGGTTTTTAGAAAAATACGGTGCTGGTG
GTTTATTCGGCGTTTTGGTTTTAGGCTACAACTTTGATCATGCATCAGTTGTAAATAGAACTAATGAATATAAAGAACAC
TATGGCCTTACTGATGGACTTGTGGTTATTGAAGATGTTGATTACTTTGCTTACTGTCTAGATACAAATAAAATGAAAGA
CGGAGAATGCCCTGTAGTTGAATGGGATAGGGTAATTGGTTATCAAGATACTGTTGCAGACAGCTTTATTGAATTTTTTT
ATAATAAGATTCAGGAAGCGAAAGATGACTGGGATGAGGATGAAGACTGGGACGATTAA
ATGATTTATTCGAAGGTTGAGAACTTTATTAATGAAAATAAACAAAATGCTATATTTACAGAAGGTGCAAGTCATGAAAA
CATTGGTCGCATTGAAGAAAACCTCCAATGCGATCTCCCCAACAGTTATAAATGGTTTTTAGAAAAATACGGTGCTGGTG
GTTTATTCGGCGTTTTGGTTTTAGGCTACAACTTTGATCATGCATCAGTTGTAAATAGAACTAATGAATATAAAGAACAC
TATGGCCTTACTGATGGACTTGTGGTTATTGAAGATGTTGATTACTTTGCTTACTGTCTAGATACAAATAAAATGAAAGA
CGGAGAATGCCCTGTAGTTGAATGGGATAGGGTAATTGGTTATCAAGATACTGTTGCAGACAGCTTTATTGAATTTTTTT
ATAATAAGATTCAGGAAGCGAAAGATGACTGGGATGAGGATGAAGACTGGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T10061 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
91.739 |
80.56 |
0.739 |
T10058 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
59.295 |
85.167 |
0.505 |
T10059 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
43.287 |
83.167 |
0.36 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A164XXS2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G4EVG5 |
References
(1) Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS Genetics 17(7):e1009682. [PubMed:34280190]
experimental literature