Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yqcG-yqcF/- |
| Location | 2656329..2658517 | Replicon | chromosome |
| Accession | NZ_CP034484 | ||
| Organism | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 | ||
Toxin (Protein)
| Gene name | yqcG | Uniprot ID | P45942 |
| Locus tag | EJJ34_RS14095 | Protein ID | WP_004399034.1 |
| Coordinates | 2656329..2657924 (+) | Length | 532 a.a. |
Antitoxin (Protein)
| Gene name | yqcF | Uniprot ID | P45941 |
| Locus tag | EJJ34_RS14100 | Protein ID | WP_009967790.1 |
| Coordinates | 2657939..2658517 (+) | Length | 193 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EJJ34_RS14065 (EJJ34_14070) | 2652043..2652483 | - | 441 | WP_003229954.1 | ArsI/CadI family heavy metal resistance metalloenzyme | - |
| EJJ34_RS14070 (EJJ34_14075) | 2652544..2652861 | - | 318 | WP_004399122.1 | arsenical resistance operon transcriptional regulator ArsR | - |
| EJJ34_RS14075 (EJJ34_14080) | 2653233..2653997 | - | 765 | WP_004398670.1 | YqcI/YcgG family protein | - |
| EJJ34_RS14080 (EJJ34_14085) | 2654440..2655567 | + | 1128 | WP_004398842.1 | response regulator aspartate phosphatase RapE | - |
| EJJ34_RS14085 (EJJ34_14090) | 2655557..2655691 | + | 135 | WP_004398770.1 | phosphatase RapE inhibitor PhrE | - |
| EJJ34_RS14090 (EJJ34_14095) | 2655801..2655959 | + | 159 | WP_003245945.1 | hypothetical protein | - |
| EJJ34_RS14095 (EJJ34_14100) | 2656329..2657924 | + | 1596 | WP_004399034.1 | LXG family T7SS effector endonuclease toxin YqcG | Toxin |
| EJJ34_RS14100 (EJJ34_14105) | 2657939..2658517 | + | 579 | WP_009967790.1 | type VII secretion system immunity protein YqcF | Antitoxin |
| EJJ34_RS14105 (EJJ34_14110) | 2658635..2658781 | + | 147 | WP_009967791.1 | hypothetical protein | - |
| EJJ34_RS14110 (EJJ34_14115) | 2658778..2659140 | - | 363 | WP_003229947.1 | hypothetical protein | - |
| EJJ34_RS14115 (EJJ34_14120) | 2659156..2659635 | - | 480 | WP_004399085.1 | hypothetical protein | - |
| EJJ34_RS14120 (EJJ34_14125) | 2659800..2660618 | - | 819 | WP_003229946.1 | N-acetylmuramoyl-L-alanine amidase CwlA | - |
| EJJ34_RS14125 (EJJ34_14130) | 2660663..2661085 | - | 423 | WP_003246208.1 | holin family protein | - |
| EJJ34_RS14130 (EJJ34_14135) | 2661130..2662023 | - | 894 | WP_003246010.1 | hypothetical protein | - |
| EJJ34_RS14135 (EJJ34_14140) | 2662111..2662275 | - | 165 | WP_003229944.1 | XkdX family protein | - |
| EJJ34_RS14140 (EJJ34_14145) | 2662272..2662607 | - | 336 | WP_009967793.1 | XkdW family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 532 a.a. Molecular weight: 68206.64 Da Isoelectric Point: 13.5250
>T10059 WP_004399034.1 NZ_CP034484:2656329-2657924 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MKVFEAKTLLTEAEKRAQEYKDLKSKMVKLKKAFKAVADLDDSEFSGKGANNIKSFYEDQAGIADQWIDLIEMKISFLTS
IPGFLEDANLSDAYIEETFLAHELANAYTKSKSIMSEQKKAMKDILNDINDILPLDLFSTETFKNELSSAEKKRKEAIEK
MDEVDQNLTSEYGLSEANEQMIQADYQALMNATAKGKSASPIHYNAKAYRDSEIHKMTEDVKKQSTDYISFKDQQAEQRR
IAKEQEELANRPWYEKSWDAVCNFTGEVSGYYDYKRAADGVDPVTGEKLTAGQRVAAGAMAAAGYIPIVGWAGKLAKGGK
AVYSTSKALYRADKALDVYKTPKTFHALQNSSKGLYGLASANGFSEAITGRDMFGNKVSKERQEQSLSGAMAMLVPFGAR
GINKKLNAKSSSRVSEASTNTSKKPKVPKTYKRPTYFRKGVRDKVWENAKDSTGSVKDPLTKQVMKKDEPWDMGHKPGYE
FRKHQQSAMERNISRKQFLDEHNNPDHYQPELPSSNRSHKGEDMTDDYFGD
MKVFEAKTLLTEAEKRAQEYKDLKSKMVKLKKAFKAVADLDDSEFSGKGANNIKSFYEDQAGIADQWIDLIEMKISFLTS
IPGFLEDANLSDAYIEETFLAHELANAYTKSKSIMSEQKKAMKDILNDINDILPLDLFSTETFKNELSSAEKKRKEAIEK
MDEVDQNLTSEYGLSEANEQMIQADYQALMNATAKGKSASPIHYNAKAYRDSEIHKMTEDVKKQSTDYISFKDQQAEQRR
IAKEQEELANRPWYEKSWDAVCNFTGEVSGYYDYKRAADGVDPVTGEKLTAGQRVAAGAMAAAGYIPIVGWAGKLAKGGK
AVYSTSKALYRADKALDVYKTPKTFHALQNSSKGLYGLASANGFSEAITGRDMFGNKVSKERQEQSLSGAMAMLVPFGAR
GINKKLNAKSSSRVSEASTNTSKKPKVPKTYKRPTYFRKGVRDKVWENAKDSTGSVKDPLTKQVMKKDEPWDMGHKPGYE
FRKHQQSAMERNISRKQFLDEHNNPDHYQPELPSSNRSHKGEDMTDDYFGD
Download Length: 1596 bp
>T10059 NZ_CP034484:2656329-2657924 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGAAAGTATTTGAAGCCAAAACCTTGCTCACCGAGGCTGAAAAGCGAGCACAGGAATACAAAGATTTAAAAAGTAAAAT
GGTCAAATTAAAGAAAGCGTTCAAAGCTGTTGCAGATTTAGATGATAGCGAGTTTTCAGGCAAAGGCGCTAATAACATTA
AATCATTTTATGAAGATCAAGCTGGCATTGCTGACCAATGGATTGATTTAATTGAGATGAAAATTTCTTTCTTAACGAGT
ATTCCTGGTTTTTTAGAAGATGCCAACTTATCAGATGCCTACATAGAAGAAACCTTTTTAGCGCATGAGCTTGCTAACGC
CTACACCAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCCATGAAAGATATATTAAATGATATCAACGATATACTGC
CTTTGGATCTGTTCTCGACAGAAACTTTTAAAAATGAACTTTCGTCTGCCGAAAAGAAACGAAAAGAAGCCATTGAGAAA
ATGGATGAAGTTGACCAAAACTTAACATCAGAATACGGACTATCAGAAGCAAATGAACAAATGATTCAAGCTGATTATCA
AGCTTTAATGAATGCGACAGCAAAAGGCAAAAGCGCCTCTCCTATTCACTATAATGCGAAGGCTTATAGAGACAGTGAGA
TTCACAAGATGACTGAGGATGTAAAGAAACAATCAACAGACTACATCTCTTTTAAGGACCAACAGGCGGAACAAAGAAGA
ATTGCAAAAGAACAAGAAGAACTGGCGAACAGACCATGGTATGAAAAGTCTTGGGATGCTGTTTGTAATTTTACAGGAGA
GGTCTCTGGATATTATGATTATAAAAGAGCCGCTGATGGGGTTGATCCTGTTACCGGCGAAAAGCTAACTGCTGGACAAC
GGGTCGCTGCCGGTGCAATGGCTGCGGCAGGATACATCCCTATCGTAGGATGGGCAGGTAAATTAGCTAAAGGTGGAAAA
GCTGTTTATTCAACAAGTAAAGCATTGTATAGAGCAGACAAAGCTCTCGATGTATATAAAACACCTAAGACATTCCATGC
CCTTCAAAACTCCAGCAAAGGACTTTATGGACTTGCTTCTGCAAATGGTTTTAGTGAAGCTATAACAGGACGCGATATGT
TCGGGAATAAAGTCTCCAAAGAGAGGCAAGAACAGAGCCTTAGTGGTGCAATGGCAATGTTGGTTCCTTTCGGAGCTCGC
GGAATTAACAAAAAGCTTAATGCAAAATCAAGTTCTCGAGTTAGCGAAGCATCGACTAACACCAGCAAAAAACCTAAAGT
TCCTAAAACGTACAAAAGACCAACTTATTTCCGTAAAGGCGTTAGAGATAAGGTTTGGGAAAATGCTAAGGATTCAACCG
GATCTGTTAAAGACCCGTTAACAAAACAAGTAATGAAAAAAGATGAACCATGGGATATGGGTCATAAACCAGGTTATGAA
TTTAGAAAACATCAACAAAGTGCGATGGAAAGAAATATTAGTCGAAAGCAATTTTTAGATGAACATAATAATCCAGACCA
CTATCAACCCGAATTACCTTCCTCCAATAGGAGTCATAAAGGGGAAGATATGACGGATGATTACTTTGGAGATTAA
ATGAAAGTATTTGAAGCCAAAACCTTGCTCACCGAGGCTGAAAAGCGAGCACAGGAATACAAAGATTTAAAAAGTAAAAT
GGTCAAATTAAAGAAAGCGTTCAAAGCTGTTGCAGATTTAGATGATAGCGAGTTTTCAGGCAAAGGCGCTAATAACATTA
AATCATTTTATGAAGATCAAGCTGGCATTGCTGACCAATGGATTGATTTAATTGAGATGAAAATTTCTTTCTTAACGAGT
ATTCCTGGTTTTTTAGAAGATGCCAACTTATCAGATGCCTACATAGAAGAAACCTTTTTAGCGCATGAGCTTGCTAACGC
CTACACCAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCCATGAAAGATATATTAAATGATATCAACGATATACTGC
CTTTGGATCTGTTCTCGACAGAAACTTTTAAAAATGAACTTTCGTCTGCCGAAAAGAAACGAAAAGAAGCCATTGAGAAA
ATGGATGAAGTTGACCAAAACTTAACATCAGAATACGGACTATCAGAAGCAAATGAACAAATGATTCAAGCTGATTATCA
AGCTTTAATGAATGCGACAGCAAAAGGCAAAAGCGCCTCTCCTATTCACTATAATGCGAAGGCTTATAGAGACAGTGAGA
TTCACAAGATGACTGAGGATGTAAAGAAACAATCAACAGACTACATCTCTTTTAAGGACCAACAGGCGGAACAAAGAAGA
ATTGCAAAAGAACAAGAAGAACTGGCGAACAGACCATGGTATGAAAAGTCTTGGGATGCTGTTTGTAATTTTACAGGAGA
GGTCTCTGGATATTATGATTATAAAAGAGCCGCTGATGGGGTTGATCCTGTTACCGGCGAAAAGCTAACTGCTGGACAAC
GGGTCGCTGCCGGTGCAATGGCTGCGGCAGGATACATCCCTATCGTAGGATGGGCAGGTAAATTAGCTAAAGGTGGAAAA
GCTGTTTATTCAACAAGTAAAGCATTGTATAGAGCAGACAAAGCTCTCGATGTATATAAAACACCTAAGACATTCCATGC
CCTTCAAAACTCCAGCAAAGGACTTTATGGACTTGCTTCTGCAAATGGTTTTAGTGAAGCTATAACAGGACGCGATATGT
TCGGGAATAAAGTCTCCAAAGAGAGGCAAGAACAGAGCCTTAGTGGTGCAATGGCAATGTTGGTTCCTTTCGGAGCTCGC
GGAATTAACAAAAAGCTTAATGCAAAATCAAGTTCTCGAGTTAGCGAAGCATCGACTAACACCAGCAAAAAACCTAAAGT
TCCTAAAACGTACAAAAGACCAACTTATTTCCGTAAAGGCGTTAGAGATAAGGTTTGGGAAAATGCTAAGGATTCAACCG
GATCTGTTAAAGACCCGTTAACAAAACAAGTAATGAAAAAAGATGAACCATGGGATATGGGTCATAAACCAGGTTATGAA
TTTAGAAAACATCAACAAAGTGCGATGGAAAGAAATATTAGTCGAAAGCAATTTTTAGATGAACATAATAATCCAGACCA
CTATCAACCCGAATTACCTTCCTCCAATAGGAGTCATAAAGGGGAAGATATGACGGATGATTACTTTGGAGATTAA
Antitoxin
Download Length: 193 a.a. Molecular weight: 24755.62 Da Isoelectric Point: 13.0833
>AT10059 WP_009967790.1 NZ_CP034484:2657939-2658517 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MGVTQENKVIARTVLGAFGGKPKVTKYWDDNKNSSIDILSVSDQPQEGITSYSTLGLSDHSINYEVNGTPLRIEIVAAME
SASDIYANVLSTCAFNIINSNFTCAPGVIFKNVISMYDQETDMKHIMFVPPFLWEEDLELLEFSNKNVTWLMALPISEGE
LQVAEKHGSDYLQDLLESKQIDIFDIKRESVV
MGVTQENKVIARTVLGAFGGKPKVTKYWDDNKNSSIDILSVSDQPQEGITSYSTLGLSDHSINYEVNGTPLRIEIVAAME
SASDIYANVLSTCAFNIINSNFTCAPGVIFKNVISMYDQETDMKHIMFVPPFLWEEDLELLEFSNKNVTWLMALPISEGE
LQVAEKHGSDYLQDLLESKQIDIFDIKRESVV
Download Length: 579 bp
>AT10059 NZ_CP034484:2657939-2658517 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGGGCGTAACACAAGAAAATAAAGTAATTGCTAGAACAGTTTTAGGAGCTTTTGGGGGGAAACCGAAGGTTACGAAATA
TTGGGATGATAACAAGAATAGCAGCATAGATATTTTATCGGTTAGTGACCAGCCTCAGGAAGGTATCACGTCATATTCAA
CTCTAGGTTTGTCGGATCATTCTATTAATTATGAGGTGAATGGCACTCCGTTGCGGATAGAAATCGTAGCTGCAATGGAG
TCAGCTTCAGACATATATGCTAATGTTTTATCAACTTGTGCCTTTAATATAATCAACTCAAATTTCACTTGTGCACCAGG
TGTTATTTTTAAAAATGTGATTAGTATGTATGATCAGGAAACCGACATGAAACATATTATGTTCGTTCCCCCATTTTTAT
GGGAGGAAGATTTAGAACTACTTGAATTTAGTAACAAAAATGTTACTTGGCTAATGGCTTTACCTATATCCGAAGGAGAA
TTGCAAGTAGCTGAAAAACACGGCTCAGATTATTTACAAGATCTTCTGGAATCAAAACAGATTGATATTTTTGATATAAA
GAGAGAATCTGTTGTTTAA
ATGGGCGTAACACAAGAAAATAAAGTAATTGCTAGAACAGTTTTAGGAGCTTTTGGGGGGAAACCGAAGGTTACGAAATA
TTGGGATGATAACAAGAATAGCAGCATAGATATTTTATCGGTTAGTGACCAGCCTCAGGAAGGTATCACGTCATATTCAA
CTCTAGGTTTGTCGGATCATTCTATTAATTATGAGGTGAATGGCACTCCGTTGCGGATAGAAATCGTAGCTGCAATGGAG
TCAGCTTCAGACATATATGCTAATGTTTTATCAACTTGTGCCTTTAATATAATCAACTCAAATTTCACTTGTGCACCAGG
TGTTATTTTTAAAAATGTGATTAGTATGTATGATCAGGAAACCGACATGAAACATATTATGTTCGTTCCCCCATTTTTAT
GGGAGGAAGATTTAGAACTACTTGAATTTAGTAACAAAAATGTTACTTGGCTAATGGCTTTACCTATATCCGAAGGAGAA
TTGCAAGTAGCTGAAAAACACGGCTCAGATTATTTACAAGATCTTCTGGAATCAAAACAGATTGATATTTTTGATATAAA
GAGAGAATCTGTTGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10060 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
49.875 |
75.518 |
0.377 |
| T10062 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
43.287 |
83.167 |
0.36 |
| T10058 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
65.6 |
47.081 |
0.309 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A164X3K4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | P45941 |
References
(1) Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS Genetics 17(7):e1009682. [PubMed:34280190]