Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | ywqJ-ywqK/- |
Location | 3720393..3722655 | Replicon | chromosome |
Accession | NZ_CP034484 | ||
Organism | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
Toxin (Protein)
Gene name | ywqJ | Uniprot ID | P96722 |
Locus tag | EJJ34_RS19710 | Protein ID | WP_003243987.1 |
Coordinates | 3720847..3722655 (-) | Length | 603 a.a. |
Antitoxin (Protein)
Gene name | ywqK | Uniprot ID | P96723 |
Locus tag | EJJ34_RS19705 | Protein ID | WP_003243602.1 |
Coordinates | 3720393..3720857 (-) | Length | 155 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EJJ34_RS19670 (EJJ34_19670) | 3716172..3716648 | + | 477 | WP_003242900.1 | chromate efflux transcriptional regulator ChrS | - |
EJJ34_RS19675 (EJJ34_19675) | 3716662..3717255 | + | 594 | WP_003227843.1 | chromate efflux transporter subunit ChrB | - |
EJJ34_RS19680 (EJJ34_19680) | 3717252..3717788 | + | 537 | WP_003227840.1 | chromate resistance efflux protein ChrA | - |
EJJ34_RS19685 (EJJ34_19685) | 3717815..3718036 | - | 222 | WP_003243378.1 | hypothetical protein | - |
EJJ34_RS19690 (EJJ34_19690) | 3718033..3718578 | - | 546 | WP_003242945.1 | flavodoxin family protein | - |
EJJ34_RS19695 (EJJ34_19695) | 3718701..3719582 | + | 882 | WP_003243262.1 | LysR family transcriptional regulator | - |
EJJ34_RS19700 (EJJ34_19700) | 3719667..3720383 | - | 717 | WP_003243213.1 | endonuclease V | - |
EJJ34_RS19705 (EJJ34_19705) | 3720393..3720857 | - | 465 | WP_003243602.1 | toxin-antitoxin system YwqK family antitoxin | Antitoxin |
EJJ34_RS19710 (EJJ34_19710) | 3720847..3722655 | - | 1809 | WP_003243987.1 | LXG family T7SS effector putative deaminase YwqJ | Toxin |
EJJ34_RS19715 (EJJ34_19715) | 3722674..3722934 | - | 261 | WP_003221757.1 | YwqI/YxiC family protein | - |
EJJ34_RS19720 (EJJ34_19720) | 3722944..3723366 | - | 423 | WP_003242741.1 | DUF5082 family protein | - |
EJJ34_RS19725 (EJJ34_19725) | 3723583..3723708 | - | 126 | WP_119123079.1 | hypothetical protein | - |
EJJ34_RS19730 (EJJ34_19730) | 3723758..3724543 | - | 786 | WP_003244223.1 | YwqG family protein | - |
EJJ34_RS19735 (EJJ34_19735) | 3724735..3726057 | - | 1323 | WP_003243223.1 | UDP-glucose 6-dehydrogenase UglF | - |
EJJ34_RS19740 (EJJ34_19740) | 3726252..3727016 | - | 765 | WP_003227815.1 | tyrosine-protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 603 a.a. Molecular weight: 88765.51 Da Isoelectric Point: 5.5500
>T10060 WP_003243987.1 NZ_CP034484:c3722655-3720847 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDNFKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNG
ISGDIKDQELNDSYVETSFLDHELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA
VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSVIEVENQGTTYIDAKTQQAEARR
LQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKRATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGK
AIYKTGKAAIAAEHALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAITIIGGAGLA
HYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKEDLHHRINLRAEVLNELSRIKSSGLTKKQRG
PAVAGVLDKKTGNYYFGINNIDGKPPKVLHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMV
YVVSARKINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK
MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDNFKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNG
ISGDIKDQELNDSYVETSFLDHELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA
VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSVIEVENQGTTYIDAKTQQAEARR
LQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKRATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGK
AIYKTGKAAIAAEHALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAITIIGGAGLA
HYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKEDLHHRINLRAEVLNELSRIKSSGLTKKQRG
PAVAGVLDKKTGNYYFGINNIDGKPPKVLHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMV
YVVSARKINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK
Download Length: 1809 bp
>T10060 NZ_CP034484:c3722655-3720847 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGAGTAAAGTATTTGAATCAAAATCTTTAATCGAAGAAGCGAAGAGCAGAAAAAAGCAATATGAGACGCTTGAAGAGCA
GCTGAATACGCTGAAAAAAGCGTTTCAGGGAGTTGCCGATTTAGGCGATAATTTTAAAGGAAATGGCGCGGACAATATTA
AAGATTTTTTTCAGGGACAGGCAGAAATCGTAGACAGCTGGCTGACGCTTGTCTCTGCTCAAATTGCGTTTTTAAACGGC
ATTTCAGGAGATATTAAAGATCAAGAACTGAATGATTCATATGTGGAAACTTCTTTTTTGGATCATGAGCTGCCCAATGG
AGACCTGAAAGCCTCAGAGATTGTCTCCGCTCATAAAGAAGAAATCGATTCTATTTTGTCAGGCATCAGCGATATTATTG
ATCTCGACATGTACACGCTTGACGACTATGCAGATAAGATGGGCGATGCCCAAAAAATCAGACGTGATACAATCACAGCT
GTCGATAAGCTTGATGAATCCCTGACCACTGAATATCAAAATTTAGAATCTCTGGACAACGCAGTGCTCACCAAATATTC
TGTTCTCATGCAGGCCACCAGCAATGGGAAGAGCGCATCCCCTATGTACTATGACAAAAAAGCCTTCCACAGCAATGAAG
TCTACAAAAGCGTCATTGAAGTAGAAAATCAAGGAACAACCTATATCGATGCAAAAACCCAGCAAGCAGAAGCAAGACGG
CTCCAGGAAAAAGCCGAGGAAGAAGCAAACAAACCGTGGTACGAAAAAACATGGGATGGAGTTTGCAACTTTACTGGAGA
AGTCACTGGCTATTATGATTATAAAAGAGCAACCGAAGGCGTTGATCCGGTTACCGGAGAAAAACTCTCCACCGCGGAGC
GTGTGACAGCAGGAGCTATGGCCGCTGCCGGATTCATACCAGTCGTCGGCTGGGCAGGCCGGGCCTTCAAAGGCGGAAAA
GCCATCTACAAAACCGGAAAAGCAGCTATCGCTGCTGAACACGCATTAGACGCCTACAAAACAGGCAAATCCTTAGACAT
TCTCAAAATGACAGAAATGGGCGCATACGGCCTTGTTGCGTCAAACGGATTCTCAGAAGCTGTCACAGGCCGGGATATGT
TCGGAAACAAAGTGTCTGAGGAGAAGCGGAAGCAAGGGGCGCTGGAAGCTATTACTATTATTGGTGGAGCAGGATTGGCA
CACTACTTTGATCGGTTGTACCAAAAAAATGCTCCATATGTCAATAAAGTGAGTAATGAAAGCCTTATTAGCAATATTGC
TAAGACTACTGAAGAAAAACAAACTAGGCTTCAATATTTAAGAAATAAGCATGGTGTATTGTCTAAAGAAGATCTTCACC
ATCGAATAAATCTAAGGGCAGAAGTACTAAACGAACTTAGTAGAATTAAATCTTCTGGTCTAACTAAAAAACAAAGAGGC
CCTGCGGTAGCTGGTGTATTGGACAAAAAAACAGGCAATTATTATTTTGGAATAAACAATATAGATGGGAAGCCACCTAA
GGTACTACATCCACTTATTCATGATAGAATTGTAAATATGCCTACAGAACTTAAAGAAGGTTATATAAAGACGTCAGGGG
CGGGTTCTCATGCCGAAGTTAATGCTCTAAATGAAGCGTTACTTCAAAGACCTGATGCGGATTTAAAAGATTTAATGGTA
TATGTAGTAAGTGCTAGGAAAATAAATAAAAAGATGCCAGAAGGTGTCCCAATGCCTAGATGTCCACATTGTGAATATAT
AACTCAAAATACAAATTATATACCGGAGGCTTTAAAGTATGGAAAATGA
ATGAGTAAAGTATTTGAATCAAAATCTTTAATCGAAGAAGCGAAGAGCAGAAAAAAGCAATATGAGACGCTTGAAGAGCA
GCTGAATACGCTGAAAAAAGCGTTTCAGGGAGTTGCCGATTTAGGCGATAATTTTAAAGGAAATGGCGCGGACAATATTA
AAGATTTTTTTCAGGGACAGGCAGAAATCGTAGACAGCTGGCTGACGCTTGTCTCTGCTCAAATTGCGTTTTTAAACGGC
ATTTCAGGAGATATTAAAGATCAAGAACTGAATGATTCATATGTGGAAACTTCTTTTTTGGATCATGAGCTGCCCAATGG
AGACCTGAAAGCCTCAGAGATTGTCTCCGCTCATAAAGAAGAAATCGATTCTATTTTGTCAGGCATCAGCGATATTATTG
ATCTCGACATGTACACGCTTGACGACTATGCAGATAAGATGGGCGATGCCCAAAAAATCAGACGTGATACAATCACAGCT
GTCGATAAGCTTGATGAATCCCTGACCACTGAATATCAAAATTTAGAATCTCTGGACAACGCAGTGCTCACCAAATATTC
TGTTCTCATGCAGGCCACCAGCAATGGGAAGAGCGCATCCCCTATGTACTATGACAAAAAAGCCTTCCACAGCAATGAAG
TCTACAAAAGCGTCATTGAAGTAGAAAATCAAGGAACAACCTATATCGATGCAAAAACCCAGCAAGCAGAAGCAAGACGG
CTCCAGGAAAAAGCCGAGGAAGAAGCAAACAAACCGTGGTACGAAAAAACATGGGATGGAGTTTGCAACTTTACTGGAGA
AGTCACTGGCTATTATGATTATAAAAGAGCAACCGAAGGCGTTGATCCGGTTACCGGAGAAAAACTCTCCACCGCGGAGC
GTGTGACAGCAGGAGCTATGGCCGCTGCCGGATTCATACCAGTCGTCGGCTGGGCAGGCCGGGCCTTCAAAGGCGGAAAA
GCCATCTACAAAACCGGAAAAGCAGCTATCGCTGCTGAACACGCATTAGACGCCTACAAAACAGGCAAATCCTTAGACAT
TCTCAAAATGACAGAAATGGGCGCATACGGCCTTGTTGCGTCAAACGGATTCTCAGAAGCTGTCACAGGCCGGGATATGT
TCGGAAACAAAGTGTCTGAGGAGAAGCGGAAGCAAGGGGCGCTGGAAGCTATTACTATTATTGGTGGAGCAGGATTGGCA
CACTACTTTGATCGGTTGTACCAAAAAAATGCTCCATATGTCAATAAAGTGAGTAATGAAAGCCTTATTAGCAATATTGC
TAAGACTACTGAAGAAAAACAAACTAGGCTTCAATATTTAAGAAATAAGCATGGTGTATTGTCTAAAGAAGATCTTCACC
ATCGAATAAATCTAAGGGCAGAAGTACTAAACGAACTTAGTAGAATTAAATCTTCTGGTCTAACTAAAAAACAAAGAGGC
CCTGCGGTAGCTGGTGTATTGGACAAAAAAACAGGCAATTATTATTTTGGAATAAACAATATAGATGGGAAGCCACCTAA
GGTACTACATCCACTTATTCATGATAGAATTGTAAATATGCCTACAGAACTTAAAGAAGGTTATATAAAGACGTCAGGGG
CGGGTTCTCATGCCGAAGTTAATGCTCTAAATGAAGCGTTACTTCAAAGACCTGATGCGGATTTAAAAGATTTAATGGTA
TATGTAGTAAGTGCTAGGAAAATAAATAAAAAGATGCCAGAAGGTGTCCCAATGCCTAGATGTCCACATTGTGAATATAT
AACTCAAAATACAAATTATATACCGGAGGCTTTAAAGTATGGAAAATGA
Antitoxin
Download Length: 155 a.a. Molecular weight: 22830.39 Da Isoelectric Point: 5.5500
>AT10060 WP_003243602.1 NZ_CP034484:c3720857-3720393 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGLAYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKS
EKEYRYGQLHGISIIWFENGRKKSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE
MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGLAYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKS
EKEYRYGQLHGISIIWFENGRKKSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE
Download Length: 465 bp
>AT10060 NZ_CP034484:c3720857-3720393 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGGAAAATGAATATGATATGAAGAGTATAAAAGAAAAGGGAGTGGACTTTGAGGATTTATGGTTCTCTTCGGTAAGTGA
TGAGATTTTAGATAATCCTGAAGACGAAAATGGCCAGCCGTTTACAGGGCTGGCTTACGAATTATATCCAAATGGTCAAA
TCATCTATTTTACTAAATATAAGAATGGTCTGGCCCATGGTTTAACATGTGAATTTTATGAAAACGGGAATAAAAAAAGT
GAAAAAGAATACCGATATGGGCAATTGCACGGTATAAGCATAATTTGGTTTGAAAATGGCAGGAAAAAAAGTGAGCAACA
GTATGAGCATTCCATACTAATTTCTGAAAAGAATTGGGATGAAGAAGGCAATCTATTAAATAAGTACGAGATAGATACAG
ATAGTCCTCATTTTGAAATACTAGAATCGAGAAGAGAGACTCACATTAATTTAGGTCGAGAGTGA
ATGGAAAATGAATATGATATGAAGAGTATAAAAGAAAAGGGAGTGGACTTTGAGGATTTATGGTTCTCTTCGGTAAGTGA
TGAGATTTTAGATAATCCTGAAGACGAAAATGGCCAGCCGTTTACAGGGCTGGCTTACGAATTATATCCAAATGGTCAAA
TCATCTATTTTACTAAATATAAGAATGGTCTGGCCCATGGTTTAACATGTGAATTTTATGAAAACGGGAATAAAAAAAGT
GAAAAAGAATACCGATATGGGCAATTGCACGGTATAAGCATAATTTGGTTTGAAAATGGCAGGAAAAAAAGTGAGCAACA
GTATGAGCATTCCATACTAATTTCTGAAAAGAATTGGGATGAAGAAGGCAATCTATTAAATAAGTACGAGATAGATACAG
ATAGTCCTCATTTTGAAATACTAGAATCGAGAAGAGAGACTCACATTAATTTAGGTCGAGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T10059 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
49.875 |
75.518 |
0.377 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A164VD86 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A1MII5 |
References
(1) Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS Genetics 17(7):e1009682. [PubMed:34280190]
experimental literature