Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | yokI-yokJ/- |
Location | 2270434..2272655 | Replicon | chromosome |
Accession | NZ_CP034484 | ||
Organism | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
Toxin (Protein)
Gene name | yokI | Uniprot ID | O31998 |
Locus tag | EJJ34_RS11845 | Protein ID | WP_004398855.1 |
Coordinates | 2270940..2272655 (-) | Length | 572 a.a. |
Antitoxin (Protein)
Gene name | yokJ | Uniprot ID | O31997 |
Locus tag | EJJ34_RS11840 | Protein ID | WP_003246188.1 |
Coordinates | 2270434..2270931 (-) | Length | 166 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EJJ34_RS11800 (EJJ34_11805) | 2265641..2266891 | - | 1251 | WP_004398504.1 | UV-damage repair protein uvrX | - |
EJJ34_RS11805 (EJJ34_11810) | 2266884..2267216 | - | 333 | WP_004398710.1 | YolD-like family protein | - |
EJJ34_RS11810 (EJJ34_11815) | 2267390..2267725 | + | 336 | WP_004399073.1 | hypothetical protein | - |
EJJ34_RS11815 (EJJ34_11820) | 2267768..2268124 | - | 357 | WP_004398595.1 | hypothetical protein | - |
EJJ34_RS11820 (EJJ34_11825) | 2268130..2268597 | - | 468 | WP_003246138.1 | YolA family protein | - |
EJJ34_RS11825 (EJJ34_11830) | 2268828..2268944 | + | 117 | WP_009967548.1 | type I toxin-antitoxin system toxin BsrG | - |
EJJ34_RS11830 (EJJ34_11835) | 2269223..2269756 | - | 534 | WP_004399156.1 | GNAT family protein | - |
EJJ34_RS11835 (EJJ34_11840) | 2269792..2270370 | - | 579 | WP_004399123.1 | SMI1/KNR4 family protein | - |
EJJ34_RS11840 (EJJ34_11845) | 2270434..2270931 | - | 498 | WP_003246188.1 | SMI1/KNR4 family protein | Antitoxin |
EJJ34_RS11845 (EJJ34_11850) | 2270940..2272655 | - | 1716 | WP_004398855.1 | ribonuclease YeeF family protein | Toxin |
EJJ34_RS11850 (EJJ34_11855) | 2272755..2273312 | - | 558 | WP_003246042.1 | SMI1/KNR4 family protein | - |
EJJ34_RS11855 (EJJ34_11860) | 2273447..2273581 | + | 135 | WP_234047931.1 | transposase | - |
EJJ34_RS11860 (EJJ34_11865) | 2273836..2274909 | - | 1074 | WP_004399120.1 | SPBc2 prophage-derived pesticidal crystal protein-like YokG | - |
EJJ34_RS11865 (EJJ34_11870) | 2275211..2276101 | + | 891 | WP_004399048.1 | endonuclease YokF | - |
EJJ34_RS11870 (EJJ34_11875) | 2276115..2276597 | + | 483 | WP_004398883.1 | PH domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 572 a.a. Molecular weight: 84203.03 Da Isoelectric Point: 5.5500
>T10061 WP_004398855.1 NZ_CP034484:c2272655-2270940 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MKVFEADSLLSEADKRTKEYKELRSQMVKLKKAFKAVADLDDSKFSGKGADNIKAFYHDHVGVTDQWIDLIDMKIVFLSS
ISAKLEDAKMSDAYIEESFLEHELVNAYTKSKSIMSEQKKAMKDILNDINDILPLEIFSTEDFKDKLSSADDKREKTIDK
INKLDEDLKTEYAETEQNEQFIQQDFKKLQESTGKGKNATPIHYSAKAYRESDIHKKKGDIEQHSEAYLTVKKEEAKERE
IKELKKKLNDGVSDPDEYLEIAKKVGYENLEPAQVQLAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGLWDFI
TDPGETLSALGNAVIHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAAAVIGTKGAGAINKADAAGKVINK
ASQAGKKIKDVKIPDLLPYNPKYDLAMAGDVPYNVVDGENLKNQLMSFAKGSDKEVKPFDVVDYRPSNSPLENHHGVMDV
WAKHNVPNYVSRGSNTPTVALTKEQHNATKKVYREWLFEKTGKKVGGKVNWKEVSPREIQELTEKMFDAANVPKEARQQY
YNAFNQYNFRK
MKVFEADSLLSEADKRTKEYKELRSQMVKLKKAFKAVADLDDSKFSGKGADNIKAFYHDHVGVTDQWIDLIDMKIVFLSS
ISAKLEDAKMSDAYIEESFLEHELVNAYTKSKSIMSEQKKAMKDILNDINDILPLEIFSTEDFKDKLSSADDKREKTIDK
INKLDEDLKTEYAETEQNEQFIQQDFKKLQESTGKGKNATPIHYSAKAYRESDIHKKKGDIEQHSEAYLTVKKEEAKERE
IKELKKKLNDGVSDPDEYLEIAKKVGYENLEPAQVQLAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGLWDFI
TDPGETLSALGNAVIHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAAAVIGTKGAGAINKADAAGKVINK
ASQAGKKIKDVKIPDLLPYNPKYDLAMAGDVPYNVVDGENLKNQLMSFAKGSDKEVKPFDVVDYRPSNSPLENHHGVMDV
WAKHNVPNYVSRGSNTPTVALTKEQHNATKKVYREWLFEKTGKKVGGKVNWKEVSPREIQELTEKMFDAANVPKEARQQY
YNAFNQYNFRK
Download Length: 1716 bp
>T10061 NZ_CP034484:c2272655-2270940 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGAAGGTATTTGAAGCTGATTCATTGCTCTCTGAAGCGGATAAAAGAACCAAAGAGTATAAGGAACTAAGGTCGCAAAT
GGTGAAGCTCAAAAAAGCGTTTAAAGCTGTAGCTGACCTAGACGACAGCAAGTTTTCAGGTAAGGGTGCAGACAACATTA
AAGCATTTTATCATGACCATGTCGGCGTTACAGATCAATGGATTGATCTTATCGATATGAAAATTGTTTTCTTAAGCAGC
ATTTCTGCAAAACTTGAAGACGCTAAGATGTCTGATGCATACATAGAAGAATCCTTCTTAGAACATGAACTTGTAAATGC
ATACACAAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCAATGAAAGACATTTTAAACGACATCAATGATATTCTTC
CACTTGAAATATTCTCAACAGAAGACTTCAAAGACAAACTTTCCTCTGCAGATGACAAACGTGAAAAAACAATCGATAAG
ATAAACAAGCTTGATGAGGATTTAAAAACAGAGTACGCTGAGACTGAACAAAATGAACAATTCATCCAGCAAGATTTTAA
AAAGCTGCAGGAATCAACAGGCAAAGGGAAGAACGCCACACCGATTCACTATAGCGCCAAAGCGTATAGAGAAAGTGACA
TACATAAGAAAAAAGGCGATATTGAGCAGCATTCAGAAGCTTATTTAACCGTGAAGAAAGAAGAAGCAAAGGAACGTGAA
ATCAAGGAATTAAAGAAAAAACTTAATGACGGTGTGTCTGATCCTGATGAATATTTAGAGATTGCTAAGAAAGTAGGGTA
CGAGAATCTGGAGCCAGCTCAAGTACAGCTTGCAGTGCAAATTGAACAAGCAAAGCAGCTAGAAGGAGCAGGAGAAATCA
CCTGGGACATCGTAAAAGGTGTAGGGGTAGGCTTATATGACGTTGGCAAAGACACTGTAACCGGCTTATGGGACTTCATC
ACCGATCCAGGAGAAACATTGTCAGCGCTTGGCAATGCAGTTATTCATCCAGTTAAAACATATGATGCAATATCTGCTGC
AATTGAAGAGTCATATCAAAAGGATATGGTGAATGGAGATGCCTATTCAAGGTCAAGATGGGTAACGTATGCAATTGGCT
CAGTGGCTGCAGCTGTTATCGGAACAAAAGGTGCAGGAGCCATTAACAAAGCTGATGCAGCAGGCAAGGTAATAAATAAA
GCTAGTCAAGCAGGGAAGAAAATTAAGGACGTCAAGATTCCAGATTTGCTGCCTTATAACCCTAAGTACGATCTTGCTAT
GGCAGGGGACGTGCCATACAATGTAGTGGATGGAGAAAACTTAAAAAATCAGCTAATGAGTTTTGCTAAAGGGTCAGATA
AAGAAGTAAAACCTTTCGATGTCGTTGATTATAGACCAAGTAACAGTCCTTTAGAGAATCATCACGGTGTAATGGACGTA
TGGGCTAAACACAATGTTCCGAATTATGTGAGTAGAGGGAGTAACACACCAACAGTAGCTTTAACTAAGGAACAACACAA
CGCTACCAAGAAAGTATATAGAGAATGGTTGTTCGAAAAAACAGGGAAGAAAGTTGGCGGCAAAGTAAACTGGAAAGAAG
TATCCCCCAGAGAAATACAAGAACTTACTGAGAAGATGTTTGATGCTGCTAATGTTCCTAAAGAAGCTAGACAGCAATAT
TATAACGCATTTAATCAATACAACTTTAGAAAGTAG
ATGAAGGTATTTGAAGCTGATTCATTGCTCTCTGAAGCGGATAAAAGAACCAAAGAGTATAAGGAACTAAGGTCGCAAAT
GGTGAAGCTCAAAAAAGCGTTTAAAGCTGTAGCTGACCTAGACGACAGCAAGTTTTCAGGTAAGGGTGCAGACAACATTA
AAGCATTTTATCATGACCATGTCGGCGTTACAGATCAATGGATTGATCTTATCGATATGAAAATTGTTTTCTTAAGCAGC
ATTTCTGCAAAACTTGAAGACGCTAAGATGTCTGATGCATACATAGAAGAATCCTTCTTAGAACATGAACTTGTAAATGC
ATACACAAAATCAAAATCCATTATGTCTGAACAGAAAAAAGCAATGAAAGACATTTTAAACGACATCAATGATATTCTTC
CACTTGAAATATTCTCAACAGAAGACTTCAAAGACAAACTTTCCTCTGCAGATGACAAACGTGAAAAAACAATCGATAAG
ATAAACAAGCTTGATGAGGATTTAAAAACAGAGTACGCTGAGACTGAACAAAATGAACAATTCATCCAGCAAGATTTTAA
AAAGCTGCAGGAATCAACAGGCAAAGGGAAGAACGCCACACCGATTCACTATAGCGCCAAAGCGTATAGAGAAAGTGACA
TACATAAGAAAAAAGGCGATATTGAGCAGCATTCAGAAGCTTATTTAACCGTGAAGAAAGAAGAAGCAAAGGAACGTGAA
ATCAAGGAATTAAAGAAAAAACTTAATGACGGTGTGTCTGATCCTGATGAATATTTAGAGATTGCTAAGAAAGTAGGGTA
CGAGAATCTGGAGCCAGCTCAAGTACAGCTTGCAGTGCAAATTGAACAAGCAAAGCAGCTAGAAGGAGCAGGAGAAATCA
CCTGGGACATCGTAAAAGGTGTAGGGGTAGGCTTATATGACGTTGGCAAAGACACTGTAACCGGCTTATGGGACTTCATC
ACCGATCCAGGAGAAACATTGTCAGCGCTTGGCAATGCAGTTATTCATCCAGTTAAAACATATGATGCAATATCTGCTGC
AATTGAAGAGTCATATCAAAAGGATATGGTGAATGGAGATGCCTATTCAAGGTCAAGATGGGTAACGTATGCAATTGGCT
CAGTGGCTGCAGCTGTTATCGGAACAAAAGGTGCAGGAGCCATTAACAAAGCTGATGCAGCAGGCAAGGTAATAAATAAA
GCTAGTCAAGCAGGGAAGAAAATTAAGGACGTCAAGATTCCAGATTTGCTGCCTTATAACCCTAAGTACGATCTTGCTAT
GGCAGGGGACGTGCCATACAATGTAGTGGATGGAGAAAACTTAAAAAATCAGCTAATGAGTTTTGCTAAAGGGTCAGATA
AAGAAGTAAAACCTTTCGATGTCGTTGATTATAGACCAAGTAACAGTCCTTTAGAGAATCATCACGGTGTAATGGACGTA
TGGGCTAAACACAATGTTCCGAATTATGTGAGTAGAGGGAGTAACACACCAACAGTAGCTTTAACTAAGGAACAACACAA
CGCTACCAAGAAAGTATATAGAGAATGGTTGTTCGAAAAAACAGGGAAGAAAGTTGGCGGCAAAGTAAACTGGAAAGAAG
TATCCCCCAGAGAAATACAAGAACTTACTGAGAAGATGTTTGATGCTGCTAATGTTCCTAAAGAAGCTAGACAGCAATAT
TATAACGCATTTAATCAATACAACTTTAGAAAGTAG
Antitoxin
Download Length: 166 a.a. Molecular weight: 24449.33 Da Isoelectric Point: 5.5500
>AT10061 WP_003246188.1 NZ_CP034484:c2270931-2270434 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MSIDMLIKKIASTSDCRLFEADGLPVIDEKHQLPKDISEFYEQCGGAVLYENADYPIYIVRPAEFELANPIIVGELCEED
ISSEWYIVCTDGKGEYLTIDLNDQRKGKCYDSFFDRHGIVGETQVIASSFTDLIQRLLENKGKHWYWLRDDYVSLGDAYD
GIEIE
MSIDMLIKKIASTSDCRLFEADGLPVIDEKHQLPKDISEFYEQCGGAVLYENADYPIYIVRPAEFELANPIIVGELCEED
ISSEWYIVCTDGKGEYLTIDLNDQRKGKCYDSFFDRHGIVGETQVIASSFTDLIQRLLENKGKHWYWLRDDYVSLGDAYD
GIEIE
Download Length: 498 bp
>AT10061 NZ_CP034484:c2270931-2270434 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
TTGAGCATTGACATGTTAATCAAGAAGATTGCTTCTACATCAGACTGTCGGCTGTTTGAAGCTGATGGTCTCCCAGTAAT
AGACGAGAAGCATCAACTACCAAAAGATATTAGTGAATTTTATGAACAATGTGGTGGAGCAGTTTTATATGAAAATGCGG
ATTATCCAATATACATAGTACGACCAGCTGAGTTTGAATTAGCTAATCCCATTATTGTTGGGGAGCTCTGTGAAGAAGAC
ATTTCATCCGAGTGGTATATTGTTTGCACGGATGGAAAAGGAGAATACCTAACAATTGACTTAAACGATCAGCGAAAAGG
AAAATGCTATGACAGTTTTTTTGATCGACATGGAATAGTCGGCGAAACACAGGTGATAGCAAGTTCATTTACAGATTTAA
TACAGCGACTGCTTGAAAATAAGGGTAAACATTGGTATTGGTTAAGGGATGATTATGTATCACTAGGCGATGCATATGAT
GGCATAGAAATTGAATAA
TTGAGCATTGACATGTTAATCAAGAAGATTGCTTCTACATCAGACTGTCGGCTGTTTGAAGCTGATGGTCTCCCAGTAAT
AGACGAGAAGCATCAACTACCAAAAGATATTAGTGAATTTTATGAACAATGTGGTGGAGCAGTTTTATATGAAAATGCGG
ATTATCCAATATACATAGTACGACCAGCTGAGTTTGAATTAGCTAATCCCATTATTGTTGGGGAGCTCTGTGAAGAAGAC
ATTTCATCCGAGTGGTATATTGTTTGCACGGATGGAAAAGGAGAATACCTAACAATTGACTTAAACGATCAGCGAAAAGG
AAAATGCTATGACAGTTTTTTTGATCGACATGGAATAGTCGGCGAAACACAGGTGATAGCAAGTTCATTTACAGATTTAA
TACAGCGACTGCTTGAAAATAAGGGTAAACATTGGTATTGGTTAAGGGATGATTATGTATCACTAGGCGATGCATATGAT
GGCATAGAAATTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T10062 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
91.739 |
80.56 |
0.739 |
T10058 | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 |
61.02 |
85.814 |
0.524 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A162SBZ6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | O31997 |
References
(1) Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS Genetics 17(7):e1009682. [PubMed:34280190]
experimental literature