MGE detailed information

MGE type: Conjugative plasmid        MGE length: 138020 bp
Accession: NZ_CP103593        Location: 1..138020         Organism: Escherichia coli O25b:H4-ST131 strain 4224       Replicon: plasmid pMB7542_1


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S53_RS24945 (1) 1..978 + 978 WP_000361610.1 RepB family plasmid replication initiator protein -
M5S53_RS24950 (1263) 1263..2003 - 741 WP_001066941.1 tyrosine-type recombinase/integrase -
M5S53_RS24955 (2124) 2124..2312 - 189 WP_001309252.1 hypothetical protein -
M5S53_RS24960 (2679) 2679..3848 + 1170 WP_001072358.1 hypothetical protein -
M5S53_RS24965 (4074) 4074..4249 - 176 Protein_4 IS3 family transposase -
M5S53_RS24970 (4695) 4695..4967 - 273 WP_001322642.1 Major pilu subunit operon regulatory protein PapB VF
M5S53_RS24975 (5504) 5504..5928 - 425 Protein_6 IS3 family transposase IS2 Transposase
M5S53_RS24980 (6210) 6210..8180 + 1971 WP_001298664.1 Hemin receptor VF
M5S53_RS24985 (8187) 8187..8804 + 618 WP_259384718.1 DUF4198 domain-containing protein -
M5S53_RS24990 (8725) 8725..10296 - 1572 WP_000381395.1 IS66 family transposase ISCro1 Transposase
M5S53_RS24995 (10316) 10316..10663 - 348 WP_000624622.1 IS66 family transposase ISCro1 Transposase
M5S53_RS25000 (10663) 10663..11340 - 678 WP_001339397.1 IS66 family transposase ISCro1 Transposase
M5S53_RS25005 (11446) 11446..11685 + 240 WP_259384719.1 hypothetical protein -
M5S53_RS25010 (11748) 11748..12356 - 609 Protein_13 IS66 family transposase ISEc22 Transposase
M5S53_RS25015 (12424) 12424..13206 - 783 WP_001300609.1 IS21 family transposase IS100kyp Transposase
M5S53_RS25020 (13203) 13203..14225 - 1023 WP_001310017.1 IS21 family transposase IS100kyp Transposase
M5S53_RS25025 (14311) 14311..15256 - 946 Protein_16 IS66 family transposase ISEc8 Transposase
M5S53_RS25030 (15305) 15305..15652 - 348 WP_000612626.1 IS66 family transposase ISKpn24 Transposase
M5S53_RS25035 (15649) 15649..16053 - 405 WP_000839179.1 IS66 family transposase ISEc22 Transposase
M5S53_RS25040 (16133) 16133..16351 - 219 Protein_19 IS3 family transposase -
M5S53_RS25045 (16417) 16417..17121 + 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
M5S53_RS25050 (17192) 17192..17896 + 705 WP_180327046.1 replication initiation protein RepE -
M5S53_RS25055 (18484) 18484..19650 + 1167 WP_000772446.1 hypothetical protein VF
M5S53_RS25060 (19650) 19650..20621 + 972 WP_000817036.1 ParB/RepB/Spo0J family plasmid partition protein -
M5S53_RS25065 (21488) 21488..22390 + 903 WP_001348615.1 DUF1281 domain-containing protein -
M5S53_RS25070 (22387) 22387..22698 + 312 WP_032143366.1 hypothetical protein -
M5S53_RS25075 (22775) 22775..23458 + 684 WP_000086185.1 DNA methylase -
M5S53_RS25080 (23459) 23459..23680 + 222 WP_001104873.1 hypothetical protein -
M5S53_RS25085 (23610) 23610..24128 + 519 WP_123325260.1 DUF1380 family protein -
M5S53_RS25090 (24179) 24179..24955 + 777 WP_001753849.1 hypothetical protein -
M5S53_RS25095 (25372) 25372..25797 + 426 WP_001198928.1 antirestriction protein -
M5S53_RS25100 (25844) 25844..26266 + 423 WP_000271753.1 DUF1380 family protein -
M5S53_RS25105 (26263) 26263..26454 + 192 WP_001027516.1 hypothetical protein -
M5S53_RS25110 (27489) 27489..27719 + 231 WP_000218642.1 hypothetical protein -
M5S53_RS25115 (27771) 27771..29132 + 1362 WP_000170714.1 DUF3560 domain-containing protein -
M5S53_RS25120 (29180) 29180..29743 + 564 WP_001348621.1 class I SAM-dependent methyltransferase -
M5S53_RS25125 (29769) 29769..30017 + 249 WP_001553845.1 hypothetical protein -
M5S53_RS25130 (30180) 30180..30515 + 336 WP_013023883.1 hypothetical protein -
M5S53_RS25135 (30428) 30428..30634 + 207 WP_000547975.1 hypothetical protein -
M5S53_RS25140 (30660) 30660..31199 + 540 WP_000290841.1 single-stranded DNA-binding protein -
M5S53_RS25145 (31262) 31262..31495 + 234 WP_000005990.1 DUF905 family protein -
M5S53_RS25150 (31561) 31561..33519 + 1959 WP_000117179.1 ParB/RepB/Spo0J family partition protein -
M5S53_RS25155 (33574) 33574..34008 + 435 WP_000845940.1 conjugation system SOS inhibitor PsiB -
M5S53_RS25160 (34005) 34005..34767 + 763 Protein_43 plasmid SOS inhibition protein A -
- (34736) 34736..34922 + 187 NuclAT_0 - -
- (34736) 34736..34922 + 187 NuclAT_0 - -
- (34736) 34736..34922 + 187 NuclAT_0 - -
- (34736) 34736..34922 + 187 NuclAT_0 - -
M5S53_RS25165 (34970) 34970..36339 + 1370 WP_085947770.1 IS3 family transposase IS150 Transposase
- (36366) 36366..36406 + 41 NuclAT_1 - Antitoxin Detail
- (36366) 36366..36406 + 41 NuclAT_1 - Antitoxin Detail
- (36366) 36366..36406 + 41 NuclAT_1 - Antitoxin Detail
- (36366) 36366..36406 + 41 NuclAT_1 - Antitoxin Detail
M5S53_RS25170 (36392) 36392..36541 + 150 Protein_45 plasmid maintenance protein Mok -
M5S53_RS25175 (36483) 36483..36608 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin Detail
M5S53_RS25180 (36828) 36828..37058 + 231 WP_001426396.1 hypothetical protein -
M5S53_RS25185 (37056) 37056..37229 - 174 Protein_48 hypothetical protein -
M5S53_RS25190 (37299) 37299..37505 + 207 WP_000275859.1 hypothetical protein -
M5S53_RS25195 (37530) 37530..37682 + 153 WP_231527929.1 hypothetical protein -
M5S53_RS25200 (37719) 37719..38423 + 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
M5S53_RS25205 (38369) 38369..39034 - 666 WP_259384720.1 hypothetical protein VF
M5S53_RS25210 (39374) 39374..39757 + 384 WP_001151566.1 conjugal transfer relaxosome DNA-binding protein TraM -
M5S53_RS25215 (39891) 39891..40568 + 678 WP_001348626.1 PAS domain-containing protein -
M5S53_RS25220 (40656) 40656..40883 + 228 WP_001254388.1 conjugal transfer relaxosome protein TraY -
M5S53_RS25225 (40917) 40917..41279 + 363 WP_000338606.1 type IV conjugative transfer system pilin TraA -
M5S53_RS25230 (41284) 41284..41595 + 312 WP_000012107.1 type IV conjugative transfer system protein TraL -
M5S53_RS25235 (41669) 41669..42366 + 698 WP_223216367.1 IS1 family transposase IS1G Transposase
M5S53_RS25240 (42414) 42414..42734 + 321 WP_001348757.1 conjugal transfer protein TrbA -
M5S53_RS25245 (42861) 42861..43145 + 285 WP_001617873.1 type-F conjugative transfer system pilin chaperone TraQ -
M5S53_RS25250 (43132) 43132..43677 + 546 WP_000059829.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
M5S53_RS25255 (43607) 43607..43954 + 348 WP_071571857.1 P-type conjugative transfer protein TrbJ -
M5S53_RS25260 (43935) 43935..44327 + 393 WP_000659962.1 F-type conjugal transfer protein TrbF -
M5S53_RS25265 (44314) 44314..45687 + 1374 WP_000944328.1 conjugal transfer pilus assembly protein TraH -
M5S53_RS25270 (45684) 45684..48503 + 2820 WP_001007062.1 conjugal transfer mating-pair stabilization protein TraG -
M5S53_RS25275 (48522) 48522..49019 + 498 WP_000605862.1 entry exclusion protein -
M5S53_RS25280 (49051) 49051..49782 + 732 WP_000850429.1 conjugal transfer complement resistance protein TraT -
M5S53_RS25285 (49985) 49985..50764 + 780 WP_000199914.1 hypothetical protein -
M5S53_RS25290 (50761) 50761..53031 + 2271 WP_094283620.1 type IV conjugative transfer system coupling protein TraD -
M5S53_RS25295 (53031) 53031..58301 + 5271 WP_001617867.1 Multifunctional conjugation protein TraI Relaxase
M5S53_RS25300 (58321) 58321..59067 + 747 WP_000205718.1 conjugal transfer pilus acetylase TraX -
M5S53_RS25305 (59122) 59122..59682 + 561 WP_000139341.1 fertility inhibition protein FinO -
M5S53_RS25310 (59813) 59813..60025 + 213 WP_013023861.1 hypothetical protein -
M5S53_RS25315 (60584) 60584..61009 + 426 WP_000422741.1 IS66 family transposase ISEc23 Transposase
M5S53_RS25320 (61006) 61006..61356 + 351 WP_000624722.1 IS66 family transposase ISEc23 Transposase
M5S53_RS25325 (61387) 61387..63000 + 1614 WP_000080195.1 IS66 family transposase ISEc23 Transposase
M5S53_RS25330 (63078) 63078..63364 + 287 Protein_77 DUF2726 domain-containing protein -
- (63331) 63331..63391 - 61 NuclAT_2 - Antitoxin Detail
- (63331) 63331..63391 - 61 NuclAT_2 - Antitoxin Detail
- (63331) 63331..63391 - 61 NuclAT_2 - Antitoxin Detail
- (63331) 63331..63391 - 61 NuclAT_2 - Antitoxin Detail
M5S53_RS25335 (63436) 63436..63570 + 135 WP_023144756.1 Hok/Gef family protein Toxin Detail
M5S53_RS25340 (63888) 63888..64121 + 234 WP_214124381.1 replication regulatory protein RepA -
M5S53_RS25345 (64227) 64227..64358 + 132 Protein_80 protein CopA/IncA -
M5S53_RS25350 (64358) 64358..64432 + 75 WP_031943482.1 RepA leader peptide Tap -
M5S53_RS25355 (64425) 64425..65282 + 858 WP_001617855.1 incFII family plasmid replication initiator RepA -
M5S53_RS25360 (66222) 66222..66875 + 654 WP_000616807.1 CPBP family intramembrane metalloprotease -
M5S53_RS25365 (66968) 66968..67225 + 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
M5S53_RS25370 (67158) 67158..67559 + 402 WP_001398199.1 type II toxin-antitoxin system toxin endoribonuclease PemK -
M5S53_RS25375 (67808) 67808..68223 + 416 Protein_86 IS1 family transposase -
M5S53_RS25380 (68259) 68259..68804 - 546 Protein_87 Tn3 family transposase TnpA_Tn3 Transposase
M5S53_RS25385 (68870) 68870..69574 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
M5S53_RS25390 (69888) 69888..70763 + 876 WP_032277257.1 Beta-lactamase CTX-M-97 ARG
M5S53_RS25395 (70798) 70798..71160 + 363 Protein_90 IS5 family transposase IS903B Transposase
M5S53_RS25400 (71220) 71220..71924 + 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
M5S53_RS25405 (72077) 72077..72937 + 861 WP_000493383.1 EamA family transporter -
M5S53_RS25410 (72969) 72969..74168 - 1200 WP_000804064.1 Tetracycline resistance protein, class C ARG
M5S53_RS25415 (74274) 74274..74900 + 627 WP_031606906.1 tetracycline resistance transcriptional repressor TetR(A) -
M5S53_RS25420 (74932) 74932..75168 - 237 WP_042005022.1 hypothetical protein -
M5S53_RS25425 (75222) 75222..76058 - 837 WP_000480972.1 hypothetical protein ARG
M5S53_RS25430 (76058) 76058..76861 - 804 WP_001082319.1 Aminoglycoside 3'-phosphotransferase ARG
M5S53_RS25435 (76922) 76922..77737 - 816 WP_001043260.1 Dihydropteroate synthase ARG
M5S53_RS25440 (78045) 78045..78221 - 177 Protein_99 replication protein C, IncQ-type -
M5S53_RS25445 (78282) 78282..78986 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
M5S53_RS25450 (79108) 79108..80013 + 906 WP_000219391.1 hypothetical protein ARG
M5S53_RS25455 (80010) 80010..81248 + 1239 WP_000004159.1 macrolide resistance MFS transporter Mrx(A) -
M5S53_RS25460 (81248) 81248..81832 + 585 WP_001137892.1 macrolide-binding transcriptional repressor MphR(A) -
M5S53_RS25465 (82325) 82325..83089 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
M5S53_RS25470 (83207) 83207..83272 - 66 Protein_105 EAL domain-containing protein -
M5S53_RS25475 (83316) 83316..83621 - 306 WP_000130000.1 Transcriptional regulator Relaxase
M5S53_RS25480 (83632) 83632..84837 - 1206 WP_000184001.1 chromate efflux transporter -
M5S53_RS25485 (84993) 84993..85196 - 204 WP_000376616.1 hypothetical protein -
M5S53_RS25490 (85324) 85324..86163 - 840 WP_000259031.1 Dihydropteroate synthase ARG
M5S53_RS25495 (86157) 86157..86504 - 348 WP_000679427.1 Multidrug transporter EmrE ARG
M5S53_RS25500 (86710) 86710..87498 - 789 WP_000503573.1 Streptomycin 3''-adenylyltransferase ARG
M5S53_RS25505 (87629) 87629..88102 - 474 WP_001389366.1 Dihydrofolate reductase type 1 ARG
M5S53_RS25510 (88260) 88260..89009 + 750 Protein_113 IS91 family transposase ISAzo26 Transposase
M5S53_RS25515 (89068) 89068..89772 + 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
M5S53_RS25520 (89910) 89910..90080 + 171 Protein_115 DsbA family protein -
M5S53_RS25525 (90070) 90070..90576 + 507 WP_000949452.1 protein disulfide oxidoreductase -
M5S53_RS25530 (90813) 90813..91574 + 762 WP_001225378.1 Na(+)-translocating NADH-quinone reductase subunit C -
M5S53_RS25535 (91921) 91921..93807 + 1887 WP_000118029.1 FTR1 family protein -
M5S53_RS25540 (93848) 93848..94375 + 528 WP_000178050.1 iron transporter -
M5S53_RS25545 (94479) 94479..95858 + 1380 WP_000119836.1 Fe-S-containing protein -
M5S53_RS25550 (95861) 95861..97144 + 1284 WP_000964653.1 ABC transporter permease -
M5S53_RS25555 (97134) 97134..98264 + 1131 WP_000729218.1 ABC transporter permease -
M5S53_RS25560 (98269) 98269..98964 + 696 WP_000117262.1 Lipoprotein-releasing system ATP-binding protein LolD VF
M5S53_RS25565 (98951) 98951..99436 + 486 WP_001267176.1 TlpA disulfide reductase family protein -
M5S53_RS25570 (99461) 99461..99946 + 486 WP_000874189.1 hypothetical protein -
M5S53_RS25575 (100068) 100068..100701 + 634 Protein_126 histidine-type phosphatase -
M5S53_RS25580 (100851) 100851..101024 - 174 Protein_127 IS5 family transposase ISKpn26 Transposase
M5S53_RS25585 (101025) 101025..101339 - 315 Protein_128 IS5 family transposase ISKpn26 Transposase
M5S53_RS25590 (102012) 102012..102751 - 740 Protein_129 IS3 family transposase IS629 Transposase
M5S53_RS25595 (102853) 102853..103113 + 261 WP_000371882.1 hypothetical protein -
M5S53_RS25600 (103110) 103110..103619 + 510 WP_000194542.1 hypothetical protein -
M5S53_RS25605 (103639) 103639..103986 - 348 WP_000142452.1 DUF6404 family protein -
M5S53_RS25610 (104115) 104115..104450 + 336 WP_001080732.1 colicin E1 family microcin immunity protein -
M5S53_RS25615 (105902) 105902..106527 + 626 Protein_134 replication initiation protein -
M5S53_RS25620 (106901) 106901..107776 + 876 WP_001224623.1 ChaN family lipoprotein -
M5S53_RS25625 (107784) 107784..108560 + 777 WP_000981091.1 energy transducer TonB -
M5S53_RS25630 (108729) 108729..110990 + 2262 WP_001100763.1 TonB-dependent receptor -
M5S53_RS25635 (111059) 111059..112234 + 1176 WP_001020413.1 putative protein YncE VF
M5S53_RS25640 (112757) 112757..113062 - 306 Protein_139 IS91 family transposase ISSbo1 Transposase
M5S53_RS25645 (113088) 113088..113827 + 740 Protein_140 IS3 family transposase IS629 Transposase
M5S53_RS25650 (114500) 114500..116008 + 1509 WP_001189113.1 group II intron reverse transcriptase/maturase -
M5S53_RS25655 (116092) 116092..116217 + 126 Protein_142 IS3 family transposase -
M5S53_RS25660 (116270) 116270..116974 - 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
M5S53_RS25665 (117852) 117852..118658 - 807 WP_000016982.1 site-specific integrase -
M5S53_RS25670 (118659) 118659..118964 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin Detail
M5S53_RS25675 (118966) 118966..119184 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
M5S53_RS25680 (119892) 119892..120887 + 996 WP_000246636.1 hypothetical protein -
M5S53_RS25685 (120930) 120930..121823 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -
M5S53_RS25695 (122871) 122871..125987 - 3117 WP_001553854.1 HsdR family type I site-specific deoxyribonuclease -
M5S53_RS25700 (126109) 126109..127392 - 1284 WP_001617890.1 restriction endonuclease subunit S -
M5S53_RS25705 (127389) 127389..128945 - 1557 WP_001617892.1 type I restriction-modification system subunit M -
M5S53_RS25710 (129128) 129128..129349 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M5S53_RS25715 (129349) 129349..129729 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin Detail
M5S53_RS25720 (129734) 129734..129913 + 180 WP_001513661.1 hypothetical protein -
M5S53_RS25725 (129941) 129941..130219 + 279 Protein_156 pdcB -
M5S53_RS25730 (130224) 130224..130637 + 414 Protein_157 IS3 family transposase ISLad1 Transposase
M5S53_RS25735 (130587) 130587..130922 - 336 WP_169329198.1 type I deoxyribonuclease HsdR -
M5S53_RS25740 (131132) 131132..132112 - 981 WP_000019407.1 IS5 family transposase IS5D Transposase
M5S53_RS25745 (132356) 132356..133759 + 1404 WP_001373486.1 S-methylmethionine permease -
M5S53_RS25750 (133746) 133746..134678 + 933 WP_000081352.1 homocysteine S-methyltransferase -
M5S53_RS25755 (134787) 134787..135116 - 330 Protein_162 TOBE domain-containing protein -
M5S53_RS25765 (135977) 135977..136135 + 159 WP_228955855.1 abortive infection family protein -
M5S53_RS25770 (136294) 136294..137265 - 972 Protein_165 hypothetical protein -

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance