MGE detailed information
MGE type: Conjugative plasmid MGE length: 134984 bp
Accession: NZ_CP085075 Location: 1..134984 Organism: Escherichia coli strain P21_SE1_04.20 Replicon: plasmid pNDM_P21_SE1_04.20
Accession: NZ_CP085075 Location: 1..134984 Organism: Escherichia coli strain P21_SE1_04.20 Replicon: plasmid pNDM_P21_SE1_04.20
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LH372_RS24045 (1) | 1..858 | + | 858 | WP_029702152.1 | incFII family plasmid replication initiator RepA | - |
| LH372_RS24050 (1797) | 1797..2450 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| LH372_RS24055 (2543) | 2543..2800 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| LH372_RS24060 (2733) | 2733..3134 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| LH372_RS24065 (3271) | 3271..5775 | - | 2505 | Protein_4 | Tn3 family transposase TnpA_Tn5403 | Transposase |
| LH372_RS24070 (5839) | 5839..6543 | + | 705 | WP_001067855.1 | Tn3 family transposase TnpA_Tn5403 | Transposase |
| LH372_RS24075 (6598) | 6598..7464 | - | 867 | Protein_6 | IS91 family transposase ISAzo26 | Transposase |
| LH372_RS24080 (7609) | 7609..8106 | + | 498 | WP_001083725.1 | Dihydrofolate reductase | ARG |
| LH372_RS24085 (8218) | 8218..8508 | + | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
| LH372_RS24090 (8514) | 8514..9352 | + | 839 | Protein_9 | Streptomycin 3''-adenylyltransferase | ARG |
| LH372_RS24095 (9469) | 9469..9816 | + | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| LH372_RS24100 (9810) | 9810..10649 | + | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| LH372_RS24105 (11054) | 11054..12595 | + | 1542 | WP_000050481.1 | IS91 family transposase ISVsa3 | Transposase |
| LH372_RS24110 (12908) | 12908..13282 | + | 375 | Protein_13 | protein-disulfide reductase DsbD family protein | - |
| LH372_RS24115 (13382) | 13382..13939 | + | 558 | Protein_14 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| LH372_RS24120 (13950) | 13950..14588 | - | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| LH372_RS24125 (14593) | 14593..14958 | - | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| LH372_RS24130 (14962) | 14962..15774 | - | 813 | WP_023408309.1 | Metallo-beta-lactamase type 2 | ARG |
| LH372_RS24135 (15875) | 15875..16168 | - | 294 | Protein_18 | IS30 family transposase ISAba125 | Transposase |
| LH372_RS24140 (16333) | 16333..17037 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LH372_RS24145 (17231) | 17231..17581 | - | 351 | Protein_20 | 60 kDa chaperonin | VF |
| LH372_RS24150 (17644) | 17644..18192 | + | 549 | WP_014342204.1 | cation:proton antiporter | - |
| LH372_RS24155 (18273) | 18273..19028 | - | 756 | WP_012372818.1 | 16S rRNA (guanine(1405)-N(7))-methyltransferase | ARG |
| LH372_RS24160 (19198) | 19198..20058 | - | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| LH372_RS24165 (20241) | 20241..20798 | - | 558 | WP_001235713.1 | Tn3 family transposase TnpR_Tn3 | Transposase |
| LH372_RS24170 (20962) | 20962..21180 | + | 219 | WP_001143771.1 | Tn3 family transposase TnpA_Tn3 | Transposase |
| LH372_RS24175 (21362) | 21362..22624 | + | 1263 | WP_000608644.1 | IS1380 family transposase ISEcp1 | Transposase |
| LH372_RS24180 (22880) | 22880..23755 | + | 876 | WP_000239590.1 | Beta-lactamase CTX-M-1 | ARG |
| LH372_RS24185 (23802) | 23802..24095 | - | 294 | WP_116961751.1 | WbuC family cupin fold metalloprotein | - |
| LH372_RS24190 (24160) | 24160..26379 | + | 2220 | Protein_29 | Tn3 family transposase TnpA_Tn3 | Transposase |
| LH372_RS24195 (26456) | 26456..27160 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LH372_RS24200 (27211) | 27211..27471 | - | 261 | Protein_31 | macrolide-binding transcriptional repressor MphR(A) | - |
| LH372_RS24205 (27471) | 27471..28709 | - | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| LH372_RS24210 (28706) | 28706..29611 | - | 906 | WP_000219391.1 | hypothetical protein | ARG |
| LH372_RS24215 (29733) | 29733..30437 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LH372_RS24220 (30502) | 30502..30834 | + | 333 | Protein_35 | macrolide-binding transcriptional repressor MphR(A) | - |
| LH372_RS24225 (31327) | 31327..32091 | - | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| LH372_RS24230 (32209) | 32209..32274 | - | 66 | Protein_37 | EAL domain-containing protein | - |
| LH372_RS24235 (32318) | 32318..32623 | - | 306 | WP_000130000.1 | hypothetical protein | Relaxase |
| LH372_RS24240 (32634) | 32634..33839 | - | 1206 | WP_000184001.1 | chromate efflux transporter | - |
| LH372_RS24245 (34067) | 34067..35071 | + | 1005 | WP_021546935.1 | IS110 family transposase IS4321R | Transposase |
| LH372_RS24250 (35253) | 35253..35525 | - | 273 | WP_004883563.1 | hypothetical protein | - |
| LH372_RS24255 (35653) | 35653..36492 | - | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| LH372_RS24260 (36486) | 36486..36833 | - | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| LH372_RS24265 (37039) | 37039..37827 | - | 789 | WP_000503573.1 | Streptomycin 3''-adenylyltransferase | ARG |
| LH372_RS24270 (37958) | 37958..38431 | - | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| LH372_RS24275 (38589) | 38589..39602 | + | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| LH372_RS24280 (39805) | 39805..40053 | + | 249 | Protein_47 | DUF3330 domain-containing protein | - |
| LH372_RS24285 (40106) | 40106..40810 | - | 705 | WP_001067855.1 | Tn3 family transposase TnpA_ISSba14 | Transposase |
| LH372_RS24290 (40871) | 40871..43282 | + | 2412 | Protein_49 | Tn3 family transposase TnpA_ISSba14 | Transposase |
| LH372_RS24295 (43361) | 43361..44365 | + | 1005 | WP_021546935.1 | IS110 family transposase IS4321R | Transposase |
| LH372_RS24300 (44643) | 44643..44747 | + | 105 | Protein_51 | IS5/IS1182 family transposase | - |
| LH372_RS24305 (44897) | 44897..45529 | - | 633 | Protein_52 | histidine-type phosphatase | - |
| LH372_RS24310 (45651) | 45651..46136 | - | 486 | WP_000874189.1 | hypothetical protein | - |
| LH372_RS24315 (46161) | 46161..46646 | - | 486 | WP_001267176.1 | TlpA disulfide reductase family protein | - |
| LH372_RS24320 (46633) | 46633..47328 | - | 696 | WP_000117262.1 | Lipoprotein-releasing system ATP-binding protein LolD | VF |
| LH372_RS24325 (47333) | 47333..48463 | - | 1131 | WP_000729219.1 | ABC transporter permease | - |
| LH372_RS24330 (48453) | 48453..49736 | - | 1284 | WP_000964653.1 | ABC transporter permease | - |
| LH372_RS24335 (49739) | 49739..51118 | - | 1380 | WP_000119836.1 | Fe-S-containing protein | - |
| LH372_RS24340 (51222) | 51222..51749 | - | 528 | WP_000178050.1 | iron transporter | - |
| LH372_RS24345 (51790) | 51790..53676 | - | 1887 | WP_000118029.1 | FTR1 family protein | - |
| LH372_RS24350 (54023) | 54023..54784 | - | 762 | WP_001225378.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| LH372_RS24355 (55021) | 55021..55527 | - | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| LH372_RS24360 (55517) | 55517..55687 | - | 171 | Protein_63 | DsbA family protein | - |
| LH372_RS24365 (55825) | 55825..55938 | - | 114 | Protein_64 | IS6 family transposase | - |
| LH372_RS24370 (56138) | 56138..56835 | + | 698 | WP_223350503.1 | IS1 family transposase IS1X2 | Transposase |
| LH372_RS24375 (56985) | 56985..57671 | + | 687 | Protein_66 | IS1 family transposase IS1S | Transposase |
| LH372_RS24380 (57925) | 57925..58947 | - | 1023 | WP_000361402.1 | helicase UvrD | - |
| LH372_RS24385 (58932) | 58932..60497 | - | 1566 | WP_001128474.1 | AAA family ATPase | - |
| LH372_RS24390 (60572) | 60572..60988 | - | 417 | WP_001034044.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| LH372_RS24395 (60985) | 60985..61215 | - | 231 | WP_001261286.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin Detail |
| LH372_RS24400 (61775) | 61775..61993 | + | 219 | WP_000813630.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| LH372_RS24405 (61995) | 61995..62300 | + | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| LH372_RS24410 (62301) | 62301..63107 | + | 807 | WP_226907401.1 | site-specific integrase | - |
| LH372_RS24415 (63829) | 63829..64584 | + | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| LH372_RS24420 (65172) | 65172..66338 | + | 1167 | WP_000772446.1 | Sporulation initiation inhibitor protein Soj | VF |
| LH372_RS24425 (66338) | 66338..67309 | + | 972 | WP_000817031.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| LH372_RS24430 (68047) | 68047..68949 | + | 903 | WP_064766247.1 | DUF1281 domain-containing protein | - |
| LH372_RS24435 (68946) | 68946..69257 | + | 312 | WP_012615291.1 | hypothetical protein | - |
| LH372_RS24440 (69334) | 69334..70017 | + | 684 | WP_032181561.1 | DNA methylase | - |
| LH372_RS24445 (70018) | 70018..70239 | + | 222 | WP_001104873.1 | hypothetical protein | - |
| LH372_RS24450 (70169) | 70169..70687 | + | 519 | WP_223349485.1 | DUF1380 family protein | - |
| LH372_RS24455 (70732) | 70732..71502 | + | 771 | WP_001006251.1 | hypothetical protein | - |
| LH372_RS24460 (71916) | 71916..72341 | + | 426 | WP_001546490.1 | antirestriction protein | - |
| LH372_RS24465 (72388) | 72388..72810 | + | 423 | WP_000271685.1 | DUF1380 family protein | - |
| LH372_RS24470 (72807) | 72807..72998 | + | 192 | WP_001027495.1 | hypothetical protein | - |
| LH372_RS24475 (73270) | 73270..73518 | - | 249 | WP_071781657.1 | hypothetical protein | - |
| LH372_RS24480 (74035) | 74035..74265 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| LH372_RS24485 (74317) | 74317..75678 | + | 1362 | WP_039023242.1 | DUF3560 domain-containing protein | - |
| LH372_RS24490 (75726) | 75726..76289 | + | 564 | WP_029702196.1 | class I SAM-dependent methyltransferase | - |
| LH372_RS24495 (76441) | 76441..76719 | + | 279 | WP_071811814.1 | hypothetical protein | - |
| LH372_RS24500 (77650) | 77650..78219 | - | 570 | WP_089634947.1 | hypothetical protein | - |
| LH372_RS24510 (79523) | 79523..80281 | + | 759 | Protein_93 | site-specific integrase | - |
| LH372_RS24515 (80439) | 80439..81449 | + | 1011 | WP_000053332.1 | substrate-binding domain-containing protein | - |
| LH372_RS24520 (81545) | 81545..83671 | + | 2127 | WP_000253905.1 | alpha-galactosidase | - |
| LH372_RS24525 (83734) | 83734..85011 | + | 1278 | WP_001083369.1 | MFS transporter | - |
| LH372_RS24530 (85008) | 85008..86441 | + | 1434 | WP_024170639.1 | glycoside hydrolase family 32 protein | - |
| LH372_RS24535 (86636) | 86636..87958 | + | 1323 | Protein_98 | carbohydrate porin | - |
| LH372_RS24545 (89053) | 89053..89157 | - | 105 | Protein_100 | thiosulfate reductase cytochrome B subunit | - |
| LH372_RS24550 (89214) | 89214..89907 | + | 694 | Protein_101 | IS1 family transposase IS1A | Transposase |
| LH372_RS24555 (90034) | 90034..90546 | + | 513 | WP_223350513.1 | potassium channel family protein | - |
| LH372_RS24560 (90631) | 90631..90882 | + | 252 | Protein_103 | iron-containing alcohol dehydrogenase | - |
| LH372_RS24565 (91171) | 91171..91488 | - | 318 | Protein_104 | IS110 family transposase IS1618 | Transposase |
| LH372_RS24570 (91643) | 91643..91748 | + | 106 | Protein_105 | plasmid SOS inhibition protein A | - |
| - (91717) | 91717..91915 | + | 199 | NuclAT_0 | - | - |
| - (91717) | 91717..91915 | + | 199 | NuclAT_0 | - | - |
| - (91717) | 91717..91915 | + | 199 | NuclAT_0 | - | - |
| - (91717) | 91717..91915 | + | 199 | NuclAT_0 | - | - |
| LH372_RS24575 (91922) | 91922..92071 | + | 150 | Protein_106 | DUF5431 family protein | - |
| LH372_RS24580 (92022) | 92022..92138 | + | 117 | WP_001375150.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| LH372_RS24585 (92439) | 92439..92736 | - | 298 | Protein_108 | hypothetical protein | - |
| LH372_RS24590 (92806) | 92806..93012 | + | 207 | WP_000275854.1 | hypothetical protein | - |
| LH372_RS24595 (93037) | 93037..93324 | + | 288 | WP_000107242.1 | hypothetical protein | - |
| LH372_RS24600 (93443) | 93443..94264 | + | 822 | WP_001234465.1 | DUF932 domain-containing protein | - |
| LH372_RS24605 (94560) | 94560..95132 | - | 573 | WP_000949660.1 | hypothetical protein | VF |
| LH372_RS24610 (95502) | 95502..95885 | + | 384 | WP_001063020.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| LH372_RS24615 (96076) | 96076..96474 | + | 399 | WP_226907400.1 | hypothetical protein | - |
| LH372_RS24625 (97635) | 97635..97850 | + | 216 | WP_001352842.1 | conjugal transfer relaxosome protein TraY | - |
| LH372_RS24630 (97893) | 97893..98258 | + | 366 | WP_000340282.1 | type IV conjugative transfer system pilin TraA | - |
| LH372_RS24635 (98273) | 98273..98584 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| LH372_RS24640 (98606) | 98606..99172 | + | 567 | WP_000399790.1 | type IV conjugative transfer system protein TraE | - |
| LH372_RS24645 (99159) | 99159..99887 | + | 729 | WP_001230813.1 | type-F conjugative transfer system secretin TraK | - |
| LH372_RS24650 (99887) | 99887..101314 | + | 1428 | WP_106509571.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| LH372_RS24655 (101304) | 101304..101894 | + | 591 | WP_000002787.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| LH372_RS24660 (101881) | 101881..102201 | + | 321 | Protein_123 | conjugal transfer protein TrbD | - |
| LH372_RS24665 (102194) | 102194..102445 | + | 252 | WP_001038342.1 | conjugal transfer protein TrbG | - |
| LH372_RS24670 (102442) | 102442..102957 | + | 516 | WP_000809832.1 | type IV conjugative transfer system lipoprotein TraV | - |
| LH372_RS24675 (103092) | 103092..103313 | + | 222 | WP_001278692.1 | conjugal transfer protein TraR | - |
| LH372_RS24680 (103473) | 103473..106100 | + | 2628 | WP_001064264.1 | type IV secretion system protein TraC | - |
| LH372_RS24685 (106097) | 106097..106483 | + | 387 | WP_000099690.1 | type-F conjugative transfer system protein TrbI | - |
| LH372_RS24690 (106480) | 106480..107112 | + | 633 | WP_001203720.1 | type-F conjugative transfer system protein TraW | - |
| LH372_RS24695 (107109) | 107109..108101 | + | 993 | WP_001553833.1 | conjugal transfer pilus assembly protein TraU | - |
| LH372_RS24700 (108110) | 108110..108748 | + | 639 | WP_001553832.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| LH372_RS24705 (108745) | 108745..110553 | + | 1809 | WP_039023153.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| LH372_RS24710 (110580) | 110580..110837 | + | 258 | WP_039023152.1 | conjugal transfer protein TrbE | - |
| LH372_RS24715 (110830) | 110830..111573 | + | 744 | WP_001030376.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| LH372_RS24720 (111589) | 111589..111936 | + | 348 | WP_001287894.1 | conjugal transfer protein TrbA | - |
| LH372_RS24725 (112055) | 112055..112339 | + | 285 | WP_000624110.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| LH372_RS24730 (112326) | 112326..112871 | + | 546 | WP_016236310.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| LH372_RS24735 (112801) | 112801..113163 | + | 363 | WP_071550055.1 | P-type conjugative transfer protein TrbJ | - |
| LH372_RS24740 (113163) | 113163..114536 | + | 1374 | WP_039023150.1 | conjugal transfer pilus assembly protein TraH | - |
| LH372_RS24745 (114533) | 114533..117352 | + | 2820 | WP_039023149.1 | conjugal transfer mating-pair stabilization protein TraG | - |
| LH372_RS24750 (117371) | 117371..117868 | + | 498 | WP_000605862.1 | entry exclusion protein | - |
| LH372_RS24755 (117900) | 117900..118631 | + | 732 | WP_000850422.1 | conjugal transfer complement resistance protein TraT | - |
| LH372_RS24760 (118884) | 118884..121055 | + | 2172 | WP_121350052.1 | type IV conjugative transfer system coupling protein TraD | - |
| LH372_RS24765 (121064) | 121064..121462 | - | 399 | WP_039023147.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| LH372_RS24770 (121462) | 121462..121689 | - | 228 | WP_039023146.1 | toxin-antitoxin system antitoxin VapB | Antitoxin Detail |
| LH372_RS24775 (121771) | 121771..127041 | + | 5271 | WP_039023145.1 | Multifunctional conjugation protein TraI | Relaxase |
| LH372_RS24780 (127317) | 127317..128858 | + | 1542 | WP_002431311.1 | IS21 family transposase ISEc12 | Transposase |
| LH372_RS24785 (128873) | 128873..129619 | + | 747 | WP_001016257.1 | IS21 family transposase ISEc12 | Transposase |
| LH372_RS24790 (129647) | 129647..130393 | + | 747 | WP_052273601.1 | conjugal transfer pilus acetylase TraX | - |
| LH372_RS24795 (130448) | 130448..131008 | + | 561 | WP_001567328.1 | fertility inhibition protein FinO | - |
| LH372_RS24800 (131139) | 131139..131348 | + | 210 | WP_039023209.1 | hypothetical protein | - |
| LH372_RS24805 (131760) | 131760..132386 | + | 627 | WP_029702149.1 | NYN domain-containing protein | - |
| LH372_RS24810 (132538) | 132538..133107 | + | 570 | WP_029702150.1 | DUF2726 domain-containing protein | - |
| LH372_RS24815 (133320) | 133320..133748 | + | 429 | WP_029702151.1 | hypothetical protein | - |
| - (133887) | 133887..133948 | - | 62 | NuclAT_1 | - | - |
| - (133887) | 133887..133948 | - | 62 | NuclAT_1 | - | - |
| - (133887) | 133887..133948 | - | 62 | NuclAT_1 | - | - |
| - (133887) | 133887..133948 | - | 62 | NuclAT_1 | - | - |
| LH372_RS24820 (133992) | 133992..134141 | + | 150 | WP_001367749.1 | Hok/Gef family protein | - |
| LH372_RS24825 (134425) | 134425..134682 | + | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
| LH372_RS25820 (134787) | 134787..134972 | + | 186 | WP_077818652.1 | protein CopA/IncA | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|