T4SS ID	377
Strain	Brucella abortus bv. 1 str. 9-941
Replicon	chromosome II [Browse all T4SS(s) in this replicon]
Accession	NC_006933
Location	56598..67031
Name	VirB
Function	effector translocation
Classification	Type IVA; Type P
This T4SS is identified in this study.

T4SS components

Component	VirB1	VirB2	VirB3	VirB4	VirB5	VirB6	VirB7	VirB8	VirB9
Number	1	1	1	1	1	1	1	1	1
Component	VirB10	VirB11	VirD4
Number	1	1	0

The information of T4SS components from NC_006933
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	BruAb2_0056	52911..54314 [-], 1404	62317015	amino acid permease
2	BruAb2_0057	54532..55683 [-], 1152	62317016	hypothetical protein
3	BruAb2_0058	55934..56452 [-], 519	62317017	lipoprotein
4	BruAb2_0059	56598..57686 [-], 1089	62317018	type IV secretion system protein VirB11	VirB11
5	BruAb2_0060	57667..58833 [-], 1167	62317019	type IV secretion system protein VirB10	VirB10
6	BruAb2_0061	58830..59699 [-], 870	62317020	type IV secretion system protein VirB9	VirB9
7	BruAb2_0062	59696..60415 [-], 720	62317021	type IV secretion system protein VirB8	VirB8
8	BruAb2_0063	60418..60591 [-], 174	62317022	type IV secretion system protein VirB7	VirB7
9	BruAb2_0064	60755..61798 [-], 1044	62317023	type IV secretion system protein VirB6	VirB6
10	BruAb2_0065	61982..62698 [-], 717	62317024	type IV secretion system protein VirB5	VirB5
11	BruAb2_0066	62703..65198 [-], 2496	62317025	type IV secretion system protein VirB4	VirB4
12	BruAb2_0067	65198..65548 [-], 351	62317026	type IV secretion system protein VirB3	VirB3
13	BruAb2_0068	65562..65879 [-], 318	62317027	type IV secretion system protein VirB2	VirB2
14	BruAb2_0069	66315..67031 [-], 717	62317028	type IV secretion system protein VirB1	VirB1
15	BruAb2_0070	67535..68773 [-], 1239	62317029	transglycosylase
16	BruAb2_0071 (galU)	69173..70066 [+], 894	62317030	GalU, UTP--glucose-1-phosphate uridylyltransferase
17	BruAb2_0072	70119..71657 [-], 1539	62317031	hypothetical protein

Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes

Effectors

BtpB, BPE043, VceC, BPE275, RicA, VceA, BPE005, BPE123

The information of protein effectors
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	*
1	BruAb1_0752	742846..743724 [+], 879	62289692	hypothetical protein	BtpB
2	BruAb1_1029	1007678..1012339 [-], 4662	62289947	hypothetical protein	BPE043
3	BruAb1_1043	1021454..1022710 [-], 1257	62289960	hypothetical protein	VceC
4	BruAb1_1259	1240195..1240956 [-], 762	62290165	rhomboid family protein	BPE275
5	BruAb1_1263	1242884..1243411 [-], 528	62290169	ferripyochelin-binding protein	RicA
6	BruAb1_1622	1599606..1599923 [+], 318	62290510	hypothetical protein	VceA
7	BruAb1_1980	1944534..1944995 [-], 462	62290852	cyclic nucleotide-binding protein	BPE005
8	BruAb2_0122	121589..122050 [-], 462	62317077	hypothetical protein	BPE123

 This effector contains information of interaction.

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Proteins        Genes

The information on host-pathogen interaction.

#	Name(Protein GI)	Host site/Substrate	Source	Function	Reference
1	BtpB (62289692)	MYD88	murine	BtpB may interact with MYD88 to inhibit TLR signaling and interfere with activation of dendritic cells.	(1) PubMed: 23847770

This T4SE is highly identical with the protein mentioned in the literature.

(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. . Front. Cell. Infect. Microbiol. . 2013.00028 . [PudMed:23847770]

Identified as part of this study from NC_006933