T4SS ID | 377 |
Strain | Brucella abortus bv. 1 str. 9-941 |
Replicon | chromosome II [Browse all T4SS(s) in this replicon] |
Accession | NC_006933 |
Location | 56598..67031 |
Name | VirB |
Function | effector translocation |
Classification | Type IVA; Type P |
This T4SS is identified in this study. |
T4SS components |
Component | VirB1 | VirB2 | VirB3 | VirB4 | VirB5 | VirB6 | VirB7 | VirB8 | VirB9 |
Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Component | VirB10 | VirB11 | VirD4 | ||||||
Number | 1 | 1 | 0 |
The information of T4SS components from NC_006933 | ||||||
# | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | Component | |
1 | BruAb2_0056 | 52911..54314 [-], 1404 | 62317015 | amino acid permease | ||
2 | BruAb2_0057 | 54532..55683 [-], 1152 | 62317016 | hypothetical protein | ||
3 | BruAb2_0058 | 55934..56452 [-], 519 | 62317017 | lipoprotein | ||
4 | BruAb2_0059 | 56598..57686 [-], 1089 | 62317018 | type IV secretion system protein VirB11 | VirB11 | |
5 | BruAb2_0060 | 57667..58833 [-], 1167 | 62317019 | type IV secretion system protein VirB10 | VirB10 | |
6 | BruAb2_0061 | 58830..59699 [-], 870 | 62317020 | type IV secretion system protein VirB9 | VirB9 | |
7 | BruAb2_0062 | 59696..60415 [-], 720 | 62317021 | type IV secretion system protein VirB8 | VirB8 | |
8 | BruAb2_0063 | 60418..60591 [-], 174 | 62317022 | type IV secretion system protein VirB7 | VirB7 | |
9 | BruAb2_0064 | 60755..61798 [-], 1044 | 62317023 | type IV secretion system protein VirB6 | VirB6 | |
10 | BruAb2_0065 | 61982..62698 [-], 717 | 62317024 | type IV secretion system protein VirB5 | VirB5 | |
11 | BruAb2_0066 | 62703..65198 [-], 2496 | 62317025 | type IV secretion system protein VirB4 | VirB4 | |
12 | BruAb2_0067 | 65198..65548 [-], 351 | 62317026 | type IV secretion system protein VirB3 | VirB3 | |
13 | BruAb2_0068 | 65562..65879 [-], 318 | 62317027 | type IV secretion system protein VirB2 | VirB2 | |
14 | BruAb2_0069 | 66315..67031 [-], 717 | 62317028 | type IV secretion system protein VirB1 | VirB1 | |
15 | BruAb2_0070 | 67535..68773 [-], 1239 | 62317029 | transglycosylase | ||
16 | BruAb2_0071 (galU) | 69173..70066 [+], 894 | 62317030 | GalU, UTP--glucose-1-phosphate uridylyltransferase | ||
17 | BruAb2_0072 | 70119..71657 [-], 1539 | 62317031 | hypothetical protein | ||
Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any. |
Download FASTA format files |
Proteins Genes |
Effectors |
BtpB, BPE043, VceC, BPE275, RicA, VceA, BPE005, BPE123 |
The information of protein effectors | ||||||
# | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | * | |
1 | BruAb1_0752 | 742846..743724 [+], 879 | 62289692 | hypothetical protein | BtpB | |
2 | BruAb1_1029 | 1007678..1012339 [-], 4662 | 62289947 | hypothetical protein | BPE043 | |
3 | BruAb1_1043 | 1021454..1022710 [-], 1257 | 62289960 | hypothetical protein | VceC | |
4 | BruAb1_1259 | 1240195..1240956 [-], 762 | 62290165 | rhomboid family protein | BPE275 | |
5 | BruAb1_1263 | 1242884..1243411 [-], 528 | 62290169 | ferripyochelin-binding protein | RicA | |
6 | BruAb1_1622 | 1599606..1599923 [+], 318 | 62290510 | hypothetical protein | VceA | |
7 | BruAb1_1980 | 1944534..1944995 [-], 462 | 62290852 | cyclic nucleotide-binding protein | BPE005 | |
8 | BruAb2_0122 | 121589..122050 [-], 462 | 62317077 | hypothetical protein | BPE123 |
Download FASTA format files |
Proteins Genes |
# | Name(Protein GI) | Host site/Substrate | Source | Function | Reference | |
1 | BtpB (62289692) | MYD88 | murine | BtpB may interact with MYD88 to inhibit TLR signaling and interfere with activation of dendritic cells. | (1) PubMed: 23847770 |
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. . Front. Cell. Infect. Microbiol. . 2013.00028 . [PudMed:23847770] |
Identified as part of this study from NC_006933 |