| Effector Protein ID: 62289692 |
 T4SS name [ID] | VirB [377] |
| Gene symbol | - |
| Locus tag | BruAb1_0752 |
| Strain | Brucella abortus bv. 1 str. 9-941 |
| Replicon | chromosome II [GenBank: NC_006932] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 742846..743724 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | BtpB |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells.BtpB plays a major role in the modulation of host innate immune response during infection. |
| UniProt ID | Q57E10 |
| KEGG ID | bmb:BruAb1_0752 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | TIR_2 [PF13676], Evalue: 8.5e-08, Aligned region: 159-285 |
| Protein Sequence: 292 a.a. [Download] |
| >gi|62289692|ref|YP_221485.1| hypothetical protein BruAb1_0752 [Brucella abortus bv. 1 str. 9-941] MYNLFVSGWKEEWQGVPCTFDLSRCVNQHEYTDQKIAEKFGKLDGAELAELTRLPTIFAYEAACKLDPKF GLIRDVTVRRGQVRIEYEFIPVQPFLTVADFDTLAFELDIGNWEMNRTHWAVKDVNLPKELHTAKGITLP SWTRQASRAVDITQHDFDVGLSFPGEARGLVEQVARELEARVGPNAYFYDNNYVSQLARPSLDTLLQDIY RNRCKLIVVFVGDDYQRKDWCGVEFRAIREIIMARAEQRIMFVRVDDGAVDGVFRTDGYVDARRFNPSEI AQFIAERVALIT |
| - |
| Nucleotide Sequence: 879 bp [Download] |
| >gi|62288991|ref|NC_006932.1|:742846-743724 Brucella abortus bv. 1 str. 9-941 chromosome I, complete sequence ATGTACAATTTATTTGTTTCGGGCTGGAAAGAGGAGTGGCAGGGGGTGCCATGTACATTCGACCTGTCGC GTTGCGTTAACCAGCACGAATACACGGATCAGAAGATTGCCGAGAAGTTCGGAAAGCTAGACGGGGCCGA ACTGGCGGAATTGACGCGCCTTCCCACGATTTTCGCCTATGAGGCTGCCTGCAAGCTTGATCCCAAGTTC GGGCTCATCCGCGATGTTACGGTAAGGCGCGGGCAAGTGCGAATCGAGTACGAGTTCATCCCGGTCCAGC CCTTCCTGACGGTAGCAGACTTCGACACCCTCGCATTCGAGCTTGATATTGGCAATTGGGAGATGAATCG TACGCACTGGGCGGTCAAAGACGTAAACCTGCCCAAGGAGCTGCACACGGCCAAAGGAATAACTCTGCCG TCGTGGACGCGACAGGCGAGCCGTGCCGTCGATATCACTCAGCACGATTTTGACGTCGGTCTCTCTTTTC CCGGTGAGGCACGCGGGCTGGTCGAGCAAGTGGCCCGCGAACTCGAGGCACGCGTCGGTCCAAACGCCTA TTTTTACGACAACAATTATGTTTCCCAGCTTGCCCGACCGTCGCTCGACACCCTACTTCAGGACATCTAC CGCAACCGCTGCAAACTGATCGTAGTCTTCGTCGGCGACGACTATCAGCGAAAAGACTGGTGCGGCGTCG AGTTCCGCGCGATTCGCGAAATTATCATGGCACGGGCCGAACAACGGATCATGTTCGTGCGTGTGGACGA TGGCGCTGTCGATGGCGTGTTTCGCACGGACGGCTACGTGGATGCGAGACGGTTCAATCCTTCTGAGATC GCCCAGTTCATCGCCGAGCGCGTCGCCCTCATCACCTAG |
| Reference |
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
. Front. Cell. Infect. Microbiol.
. 2013.00028
. [PudMed:23847770] 
|
| experimental literature |