Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ABC812_RS05870 Genome accession   NZ_CP155537
Coordinates   1162222..1163571 (-) Length   449 a.a.
NCBI ID   WP_220041219.1    Uniprot ID   Q93QS8
Organism   Streptococcus pneumoniae strain DP1322     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1157222..1168571
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC812_RS05850 (ABC812_05845) - 1158876..1160747 (-) 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
  ABC812_RS05855 (ABC812_05850) - 1160822..1161076 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ABC812_RS05860 (ABC812_05855) relB 1161078..1161320 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ABC812_RS05865 (ABC812_05860) vicX 1161411..1162220 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ABC812_RS05870 (ABC812_05865) micB 1162222..1163571 (-) 1350 WP_220041219.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ABC812_RS05875 (ABC812_05870) micA 1163564..1164268 (-) 705 WP_000722076.1 response regulator YycF Regulator
  ABC812_RS05880 (ABC812_05875) mutY 1164323..1165498 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  ABC812_RS05885 (ABC812_05880) - 1165827..1167497 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  ABC812_RS05890 (ABC812_05885) coaB 1167727..1168416 (+) 690 WP_000699498.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51659.37 Da        Isoelectric Point: 4.9083

>NTDB_id=997479 ABC812_RS05870 WP_220041219.1 1162222..1163571(-) (micB) [Streptococcus pneumoniae strain DP1322]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSCIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=997479 ABC812_RS05870 WP_220041219.1 1162222..1163571(-) (micB) [Streptococcus pneumoniae strain DP1322]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACTAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGTATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCATGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGCTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTACTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

PAS fold (PAS)

(98-198)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q93QS8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

100

100

1
  vicK Streptococcus mutans UA159

69.652

89.532

0.624

Multiple sequence alignment