Detailed information NTG0997449

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC804_RS08490
• Genome accession: NZ_CP155536
• Coordinates: 1607394..1608131 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219127.1
• Uniprot ID: A0A4J1ZS24
• Organism: Streptococcus pneumoniae strain M264-3
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1602394..1613131

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC804_RS08460 (ABC804_08455)	comA/nlmT	1602787..1603512 (+)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator
ABC804_RS08465 (ABC804_08460)	comA/nlmT	1603502..1603942 (+)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
ABC804_RS08470 (ABC804_08465)	comA/nlmT	1603926..1604414 (+)	489	WP_307774349.1	ATP-binding cassette domain-containing protein	Regulator
ABC804_RS08475 (ABC804_08470)	-	1604425..1605786 (+)	1362	WP_001069092.1	bacteriocin secretion accessory protein	-
ABC804_RS08480 (ABC804_08475)	blpC	1605843..1605998 (+)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
ABC804_RS08485 (ABC804_08480)	-	1606040..1607380 (-)	1341	WP_001017622.1	sensor histidine kinase	-
ABC804_RS08490 (ABC804_08485)	comE/blpR	1607394..1608131 (-)	738	WP_001219127.1	response regulator transcription factor	Regulator
ABC804_RS08495 (ABC804_08490)	-	1608136..1608474 (-)	339	WP_000682119.1	LytTR family DNA-binding domain-containing protein	-
ABC804_RS08500 (ABC804_08495)	-	1608750..1609079 (+)	330	WP_000132570.1	hypothetical protein	-
ABC804_RS08505 (ABC804_08500)	-	1609247..1610296 (-)	1050	WP_000653752.1	ABC transporter permease	-
ABC804_RS08510 (ABC804_08505)	pptA	1610293..1611024 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ABC804_RS08515 (ABC804_08510)	-	1611092..1611502 (+)	411	WP_001278301.1	HIT family protein	-
ABC804_RS08520 (ABC804_08515)	-	1611512..1611799 (+)	288	WP_000777760.1	hypothetical protein	-
ABC804_RS08525 (ABC804_08520)	-	1611961..1612155 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28683.81 Da
• Isoelectric Point: 6.0431

>NTDB_id=997449 ABC804_RS08490 WP_001219127.1 1607394..1608131(-) (comE/blpR) [Streptococcus pneumoniae strain M264-3]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPSLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=997449 ABC804_RS08490 WP_001219127.1 1607394..1608131(-) (comE/blpR) [Streptococcus pneumoniae strain M264-3]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTACATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCAGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A4J1ZS24

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.498	99.184	0.531
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384