Detailed information NTG0997069

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ABC810_RS00050
• Genome accession: NZ_CP155532
• Coordinates: 7524..8276 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SP264
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2524..13276

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC810_RS00020 (ABC810_00020)	spo0J	3115..3873 (-)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator
ABC810_RS00025 (ABC810_00025)	htrA	3931..5112 (-)	1182	WP_000681598.1	S1C family serine protease	Regulator
ABC810_RS00030 (ABC810_00030)	rlmH	5295..5774 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABC810_RS00040 (ABC810_00040)	comC/comC2	6056..6181 (+)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
ABC810_RS00045 (ABC810_00045)	comD/comD2	6202..7527 (+)	1326	WP_000364843.1	competence system sensor histidine kinase ComD	Regulator
ABC810_RS00050 (ABC810_00050)	comE	7524..8276 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ABC810_RS00065 (ABC810_00065)	-	8519..9061 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ABC810_RS00070 (ABC810_00070)	-	9240..10842 (+)	1603	Protein_10	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=997069 ABC810_RS00050 WP_000866065.1 7524..8276(+) (comE) [Streptococcus pneumoniae strain SP264]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=997069 ABC810_RS00050 WP_000866065.1 7524..8276(+) (comE) [Streptococcus pneumoniae strain SP264]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408