Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   ABC803_RS01910 Genome accession   NZ_CP155531
Coordinates   349501..350121 (+) Length   206 a.a.
NCBI ID   WP_000839909.1    Uniprot ID   A0A098Z2X2
Organism   Streptococcus pneumoniae strain SN36255     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 315589..355869 349501..350121 within 0


Gene organization within MGE regions


Location: 315589..355869
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC803_RS01725 (ABC803_01725) ndk 316807..317220 (+) 414 WP_000438289.1 nucleoside-diphosphate kinase -
  ABC803_RS01730 (ABC803_01730) - 318148..318780 (-) 633 WP_000571425.1 ABC transporter ATP-binding protein -
  ABC803_RS01735 (ABC803_01735) - 318782..320797 (-) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  ABC803_RS01740 (ABC803_01740) - 321688..322905 (-) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  ABC803_RS01745 (ABC803_01745) - 322987..323190 (-) 204 WP_000814511.1 excisionase -
  ABC803_RS01750 (ABC803_01750) - 323174..323425 (+) 252 WP_001845478.1 hypothetical protein -
  ABC803_RS01755 (ABC803_01755) - 323651..323881 (-) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  ABC803_RS01760 (ABC803_01760) - 323878..324300 (-) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  ABC803_RS01765 (ABC803_01765) - 324805..325158 (+) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  ABC803_RS01770 (ABC803_01770) - 325218..325409 (-) 192 WP_001860868.1 cysteine-rich KTR domain-containing protein -
  ABC803_RS01775 (ABC803_01775) - 325931..326101 (+) 171 WP_000873143.1 hypothetical protein -
  ABC803_RS01780 (ABC803_01780) mef(A) 326487..327704 (+) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  ABC803_RS01785 (ABC803_01785) msr(D) 327824..329287 (+) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  ABC803_RS01790 (ABC803_01790) - 329405..329704 (-) 300 WP_001072467.1 DUF5960 family protein -
  ABC803_RS01795 (ABC803_01795) - 329691..330059 (-) 369 WP_000567222.1 hypothetical protein -
  ABC803_RS01800 (ABC803_01800) - 330072..330407 (-) 336 WP_000806926.1 hypothetical protein -
  ABC803_RS01805 (ABC803_01805) - 330404..330649 (-) 246 WP_001813542.1 hypothetical protein -
  ABC803_RS01810 (ABC803_01810) tet(M) 331013..332932 (-) 1920 WP_000691729.1 tetracycline resistance ribosomal protection protein Tet(M) -
  ABC803_RS01815 - 332948..332995 (-) 48 Protein_328 hypothetical protein -
  ABC803_RS01820 (ABC803_01820) - 333309..334241 (-) 933 WP_001224318.1 conjugal transfer protein -
  ABC803_RS01825 (ABC803_01825) - 334238..335239 (-) 1002 WP_000769868.1 bifunctional lysozyme/C40 family peptidase -
  ABC803_RS01830 (ABC803_01830) - 335236..337413 (-) 2178 WP_001814875.1 CD3337/EF1877 family mobilome membrane protein -
  ABC803_RS01835 (ABC803_01835) - 337416..339863 (-) 2448 WP_000331160.1 ATP-binding protein -
  ABC803_RS01840 (ABC803_01840) - 339847..340239 (-) 393 WP_000723888.1 conjugal transfer protein -
  ABC803_RS01845 (ABC803_01845) - 340328..340825 (-) 498 WP_000342539.1 antirestriction protein ArdA -
  ABC803_RS01850 (ABC803_01850) - 340942..341163 (-) 222 WP_001009056.1 hypothetical protein -
  ABC803_RS01855 (ABC803_01855) - 341343..342590 (+) 1248 WP_000019067.1 ISL3 family transposase -
  ABC803_RS01860 (ABC803_01860) erm(B) 342847..343584 (-) 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
  ABC803_RS01865 (ABC803_01865) - 343709..343792 (-) 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
  ABC803_RS01870 (ABC803_01870) - 343841..344053 (-) 213 WP_029645760.1 peptide-binding protein -
  ABC803_RS01875 (ABC803_01875) mobT 343998..345260 (-) 1263 WP_001814870.1 MobT family relaxase -
  ABC803_RS01880 (ABC803_01880) - 345283..345435 (-) 153 WP_000879507.1 hypothetical protein -
  ABC803_RS01885 (ABC803_01885) - 345438..346823 (-) 1386 WP_000813494.1 FtsK/SpoIIIE domain-containing protein -
  ABC803_RS01890 (ABC803_01890) - 346852..347238 (-) 387 WP_000985015.1 YdcP family protein -
  ABC803_RS01895 (ABC803_01895) - 347254..347568 (-) 315 WP_000420682.1 YdcP family protein -
  ABC803_RS01900 (ABC803_01900) - 347970..348140 (-) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -
  ABC803_RS01905 (ABC803_01905) - 348332..349195 (+) 864 WP_001093609.1 helix-turn-helix transcriptional regulator -
  ABC803_RS01910 (ABC803_01910) comM 349501..350121 (+) 621 WP_000839909.1 hypothetical protein Regulator
  ABC803_RS01915 (ABC803_01915) tsaE 350207..350650 (+) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  ABC803_RS01920 (ABC803_01920) - 350640..351158 (+) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  ABC803_RS01925 (ABC803_01925) - 351166..352182 (+) 1017 WP_000239278.1 LCP family protein -
  ABC803_RS01930 (ABC803_01930) cinA 352267..353523 (+) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  ABC803_RS01935 (ABC803_01935) recA 353578..354744 (+) 1167 WP_001085462.1 recombinase RecA Machinery gene

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23540.66 Da        Isoelectric Point: 10.1254

>NTDB_id=997015 ABC803_RS01910 WP_000839909.1 349501..350121(+) (comM) [Streptococcus pneumoniae strain SN36255]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=997015 ABC803_RS01910 WP_000839909.1 349501..350121(+) (comM) [Streptococcus pneumoniae strain SN36255]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z2X2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

99.515

100

0.995
  comM Streptococcus pneumoniae R6

99.515

100

0.995
  comM Streptococcus pneumoniae TIGR4

99.515

100

0.995
  comM Streptococcus mitis NCTC 12261

38.462

94.66

0.364
  comM Streptococcus mitis SK321

38.462

94.66

0.364

Multiple sequence alignment