Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ELZ47_RS00630 Genome accession   NZ_LR134002
Coordinates   116076..118019 (+) Length   647 a.a.
NCBI ID   WP_126434975.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain NCTC 10904     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 111076..123019
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ47_RS00615 (NCTC10904_00120) hexA 111105..113654 (+) 2550 WP_126434972.1 DNA mismatch repair protein MutS Machinery gene
  ELZ47_RS00620 (NCTC10904_00121) - 113839..114534 (+) 696 WP_126434973.1 zinc ribbon domain-containing protein -
  ELZ47_RS00625 (NCTC10904_00122) - 114562..115872 (+) 1311 WP_126434974.1 SPFH domain-containing protein -
  ELZ47_RS00630 (NCTC10904_00123) hexB 116076..118019 (+) 1944 WP_126434975.1 DNA mismatch repair endonuclease MutL Machinery gene
  ELZ47_RS00635 (NCTC10904_00124) - 118068..118577 (-) 510 WP_164549528.1 RDD family protein -
  ELZ47_RS00640 (NCTC10904_00125) - 118561..119064 (-) 504 WP_126434977.1 helix-turn-helix domain-containing protein -
  ELZ47_RS00645 (NCTC10904_00126) ruvA 119234..119824 (+) 591 WP_126434978.1 Holliday junction branch migration protein RuvA Machinery gene
  ELZ47_RS00650 (NCTC10904_00127) - 119835..120407 (+) 573 WP_126434979.1 DNA-3-methyladenine glycosylase I -
  ELZ47_RS00655 (NCTC10904_00128) - 120417..121265 (-) 849 WP_002917851.1 helix-turn-helix domain-containing protein -
  ELZ47_RS00665 (NCTC10904_00130) - 121864..122142 (+) 279 WP_223310420.1 bacteriocin immunity protein -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 73125.17 Da        Isoelectric Point: 5.1212

>NTDB_id=996655 ELZ47_RS00630 WP_126434975.1 116076..118019(+) (hexB) [Streptococcus sanguinis strain NCTC 10904]
MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKSIQVTDNGEGIDHEDVPLALRRHATSK
IKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATETGQHGTLLIAQGGEIEEHEPTSSPVGTKIKIEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLISDSREMTRTAGSGNLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALVSQ
AIATSLKEQDLIPDALGNLAKSTVKRASKPEQTSLPLKENRLYYDKEQNDFLLKPQVAEQQVSFEESAKPGHEATDEKAE
PQSTSVKFAERKPVSYDQLDHPELDQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVKY
EYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMELLEDAGIFLEEYGANQFILREHPIWFKEEEIEAGIYEMCDML
LLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRELGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=996655 ELZ47_RS00630 WP_126434975.1 116076..118019(+) (hexB) [Streptococcus sanguinis strain NCTC 10904]
ATGTCAAAAATTATCGAACTTCCAGAAATTCTAGCCAATCAGATTGCGGCCGGTGAGGTCATTGAGCGGCCTAGCAGCGT
GGTCAAGGAGCTGGTGGAAAATTCAATTGATGCGGGTGCCAGTCAGATTACTATCGAAATCGAAGAAGCTGGACTTAAGA
GTATTCAAGTGACGGACAATGGCGAGGGCATTGACCACGAAGATGTTCCTCTGGCTCTTCGACGCCATGCTACCAGTAAA
ATCAAGAAGCAGGCGGATCTCTTTCGAATTCGGACGCTGGGTTTTCGTGGTGAGGCCATTCCTTCCATTGCTTCTGTCTC
ACGTTTTACCATTGAGACTGCAACAGAGACTGGCCAGCACGGGACTCTACTAATTGCCCAAGGCGGTGAGATTGAAGAGC
ATGAGCCTACCAGCAGTCCGGTGGGAACGAAAATCAAGATAGAAGATCTTTTCTTTAATACTCCAGCCCGACTCAAGTAT
ATGAAGAGCCAGCAGGCTGAGCTGTCCCATATCGTTGATGTGATTAATCGGCTCAGTCTGGCCCATCCAGAAGTGGCTTT
CACCCTTATCAGCGACAGCCGCGAAATGACACGGACTGCCGGCAGTGGCAATCTTCGGCAGGCTATTGCAGGCATCTATG
GTTTGGCAACAGCTAAGAAAATGGTGGAAATCTCTGCTTCGGATTTGGACTTTGAGGTGAGTGGCTATGTCAGCTTGCCT
GAGCTGACTCGTGCAAATCGGAATTATATTACGATCCTTATCAACGGCCGCTATATTAAGAATTTCCTGCTCAATCGTGC
TATTTTGGACGGCTACGGCAGCAAGCTTATGGTAGGCCGCTTTCCACTCGCGGTCATCAATATTCAGATTGACCCCTATC
TGGCTGATGTCAATGTCCATCCGACCAAGCAAGAGGTGCGGATTTCTAAAGAGCGGGAACTCATGGCCTTGGTTTCGCAA
GCCATTGCGACCAGTCTCAAGGAGCAAGACCTTATCCCGGATGCTTTGGGAAACCTAGCCAAATCAACTGTTAAGCGTGC
CAGTAAGCCTGAACAGACCAGTCTTCCGCTGAAGGAAAATCGCCTCTACTACGATAAGGAGCAGAATGACTTCTTACTCA
AGCCACAGGTGGCAGAGCAGCAGGTATCCTTTGAAGAGTCAGCAAAGCCTGGCCATGAAGCGACAGATGAAAAAGCAGAA
CCGCAATCGACTTCGGTCAAATTCGCAGAGAGAAAGCCGGTCAGCTATGACCAGCTAGACCATCCAGAGCTAGACCAGGC
CAGTCTGGAGCGGGCTGTGGATAAGTTGGAACAGGAAGAGAAGTCAAGCTTCCCAGAGTTAGAATATTTCGGCCAGATGC
ATGGTACCTATCTCTTTGCTCAGGGCAAGGGCGGTCTTTACATTATTGACCAGCATGCTGCCCAAGAGCGGGTCAAGTAT
GAGTATTATCGGGAGAAGATAGGGGATGTGGACAATAGCCAGCAGCAGCTCTTAGTGCCCTATATCTTTGAATTTCCAGC
AGACGATATGTTGCGAATCAAGCAGCGGATGGAGCTGTTAGAAGATGCTGGCATCTTTTTAGAAGAGTACGGAGCCAATC
AATTTATTCTCCGCGAGCATCCCATTTGGTTCAAGGAAGAGGAGATTGAGGCCGGCATCTATGAGATGTGTGATATGCTT
CTCCTGACCAAGGAAGTTTCCATCAAGAAATATCGAGCAGAGCTGGCCATTATGATGAGCTGCAAACGCTCCATCAAGGC
CAATCACAGTCTGGATGACTACTCTGCGCGTGACTTGCTCTTTCAGCTGTCCCAGTGTGACAATCCTTACAACTGCCCAC
ACGGCCGACCAGTCTTGGTCAACTTTACCAAGTCGGATATGGAAAAAATGTTCCGCCGCATTCAGGAAAATCATACTAGC
CTGCGGGAGTTGGGGAAATACTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(449-591)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-117)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.573

100

0.781

Multiple sequence alignment