Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   AAYT23_RS08695 Genome accession   NZ_CP154877
Coordinates   1689781..1690401 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae strain 20234295     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1679509..1701459 1689781..1690401 within 0


Gene organization within MGE regions


Location: 1679509..1701459
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAYT23_RS08635 (AAYT23_08620) - 1679509..1680093 (-) 585 WP_001101186.1 hypothetical protein -
  AAYT23_RS08640 (AAYT23_08625) - 1680491..1680916 (-) 426 WP_001813186.1 hypothetical protein -
  AAYT23_RS08645 (AAYT23_08630) - 1681045..1681404 (-) 360 WP_001813188.1 ImmA/IrrE family metallo-endopeptidase -
  AAYT23_RS08650 (AAYT23_08635) - 1681450..1681656 (-) 207 WP_000366087.1 hypothetical protein -
  AAYT23_RS08655 (AAYT23_08640) - 1681643..1681804 (-) 162 WP_001056001.1 helix-turn-helix domain-containing protein -
  AAYT23_RS08660 (AAYT23_08645) lytA 1682150..1683106 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  AAYT23_RS08665 (AAYT23_08650) - 1683482..1684852 (-) 1371 WP_001036256.1 MATE family efflux transporter -
  AAYT23_RS08670 (AAYT23_08655) recA 1685158..1686324 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  AAYT23_RS08675 (AAYT23_08660) cinA 1686379..1687635 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  AAYT23_RS08680 (AAYT23_08665) brpA 1687720..1688736 (-) 1017 WP_000239286.1 biofilm formation/cell division transcriptional regulator BrpA -
  AAYT23_RS08685 (AAYT23_08670) - 1688744..1689262 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  AAYT23_RS08690 (AAYT23_08675) tsaE 1689252..1689695 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  AAYT23_RS08695 (AAYT23_08680) comM 1689781..1690401 (-) 621 WP_000839908.1 hypothetical protein Regulator
  AAYT23_RS08700 (AAYT23_08685) - 1690784..1691647 (-) 864 WP_001093620.1 helix-turn-helix domain-containing protein -
  AAYT23_RS08705 (AAYT23_08690) - 1691829..1691999 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  AAYT23_RS08710 (AAYT23_08695) pneA1 1692102..1692326 (+) 225 WP_000181086.1 two-peptide bacteriocin subunit PneA1 -
  AAYT23_RS08715 (AAYT23_08700) pneA2 1692333..1692521 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  AAYT23_RS08720 (AAYT23_08705) - 1692637..1695627 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  AAYT23_RS08725 (AAYT23_08710) - 1695977..1696681 (+) 705 WP_001033170.1 flavodoxin family protein -
  AAYT23_RS08730 (AAYT23_08715) - 1696662..1697591 (+) 930 WP_000912951.1 M50 family metallopeptidase -
  AAYT23_RS08735 (AAYT23_08720) - 1697588..1699696 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  AAYT23_RS08740 (AAYT23_08725) - 1699720..1701459 (+) 1740 WP_000699969.1 S8 family peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=994473 AAYT23_RS08695 WP_000839908.1 1689781..1690401(-) (comM) [Streptococcus pneumoniae strain 20234295]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=994473 AAYT23_RS08695 WP_000839908.1 1689781..1690401(-) (comM) [Streptococcus pneumoniae strain 20234295]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment