Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   AAIS09_RS08245 Genome accession   NZ_CP154595
Coordinates   1646043..1646702 (+) Length   219 a.a.
NCBI ID   WP_000565010.1    Uniprot ID   A0A0B7M2C6
Organism   Streptococcus pneumoniae strain serotype 4     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1641043..1651702
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAIS09_RS08205 (AAIS09_08190) mgaSpn 1641199..1642680 (-) 1482 WP_369916944.1 virulence factor transcriptional regulator MgaSpn -
  AAIS09_RS08210 (AAIS09_08195) - 1643123..1643287 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  AAIS09_RS08215 (AAIS09_08200) amaP 1643371..1643937 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  AAIS09_RS08220 (AAIS09_08205) - 1643949..1644119 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  AAIS09_RS08225 (AAIS09_08210) - 1644158..1644766 (+) 609 WP_061640415.1 Asp23/Gls24 family envelope stress response protein -
  AAIS09_RS08230 (AAIS09_08215) - 1644797..1645000 (+) 204 WP_000109957.1 CsbD family protein -
  AAIS09_RS08235 (AAIS09_08220) - 1645110..1645382 (-) 273 Protein_1629 transposase -
  AAIS09_RS08240 (AAIS09_08225) - 1645527..1645973 (-) 447 WP_000155430.1 GNAT family N-acetyltransferase -
  AAIS09_RS08245 (AAIS09_08230) cclA/cilC 1646043..1646702 (+) 660 WP_000565010.1 prepilin peptidase Machinery gene
  AAIS09_RS08250 (AAIS09_08235) - 1646754..1647905 (-) 1152 WP_000481756.1 XRE family transcriptional regulator -
  AAIS09_RS08255 (AAIS09_08240) - 1647920..1648651 (-) 732 WP_000934018.1 hypothetical protein -
  AAIS09_RS08260 (AAIS09_08245) - 1648871..1648981 (+) 111 Protein_1634 prepilin peptidase -
  AAIS09_RS08265 (AAIS09_08250) trpA 1648953..1649729 (-) 777 WP_001127044.1 tryptophan synthase subunit alpha -
  AAIS09_RS08270 (AAIS09_08255) trpB 1649722..1650945 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  AAIS09_RS08275 (AAIS09_08260) - 1650923..1651522 (-) 600 WP_000169913.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24845.99 Da        Isoelectric Point: 7.5762

>NTDB_id=993693 AAIS09_RS08245 WP_000565010.1 1646043..1646702(+) (cclA/cilC) [Streptococcus pneumoniae strain serotype 4]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=993693 AAIS09_RS08245 WP_000565010.1 1646043..1646702(+) (cclA/cilC) [Streptococcus pneumoniae strain serotype 4]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M2C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

100

100

1
  cclA/cilC Streptococcus pneumoniae D39

100

100

1
  cclA/cilC Streptococcus pneumoniae R6

100

100

1
  cclA/cilC Streptococcus pneumoniae TIGR4

94.977

100

0.95
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

87.671

100

0.877

Multiple sequence alignment