Detailed information NTG0993326

Bioinformatically predicted

Overview

• Name: irvR
• Type: Regulator
• Locus tag: E0E12_RS11435
• Genome accession: NZ_LR027876
• Coordinates: 2159921..2160628 (+)
• Length: 235 a.a.
• NCBI ID: WP_000094093.1
• Uniprot ID: A0A1D4DWM6
• Organism: Staphylococcus aureus strain JKD6009 isolate JKD6009
• Function: regulate expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2154921..2165628

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0E12_RS11380	-	2155675..2155938 (-)	264	WP_001205732.1	hypothetical protein	-
E0E12_RS11385	-	2155947..2156207 (-)	261	WP_000291489.1	DUF1108 family protein	-
E0E12_RS11390	-	2156300..2156461 (-)	162	WP_000066020.1	DUF1270 domain-containing protein	-
E0E12_RS11395	-	2156458..2156778 (-)	321	WP_001120197.1	DUF771 domain-containing protein	-
E0E12_RS11400	-	2156837..2157469 (+)	633	WP_000275058.1	hypothetical protein	-
E0E12_RS11405	-	2157484..2157624 (-)	141	WP_000939496.1	hypothetical protein	-
E0E12_RS11410	-	2157655..2157849 (-)	195	WP_000388066.1	hypothetical protein	-
E0E12_RS11415	-	2157866..2158618 (-)	753	WP_001148618.1	phage antirepressor KilAC domain-containing protein	-
E0E12_RS11420	-	2158675..2159214 (+)	540	WP_000351243.1	hypothetical protein	-
E0E12_RS11425	-	2159238..2159498 (-)	261	WP_000435341.1	transcriptional regulator	-
E0E12_RS11430	-	2159511..2159750 (-)	240	WP_000548578.1	helix-turn-helix transcriptional regulator	-
E0E12_RS11435	irvR	2159921..2160628 (+)	708	WP_000094093.1	helix-turn-helix domain-containing protein	Regulator
E0E12_RS15550	-	2160640..2160795 (+)	156	WP_001049399.1	hypothetical protein	-
E0E12_RS11440	-	2160782..2160967 (+)	186	WP_001089804.1	hypothetical protein	-
E0E12_RS11445	-	2161167..2161334 (+)	168	WP_000705238.1	hypothetical protein	-
E0E12_RS11450	-	2161474..2162013 (+)	540	WP_000391618.1	type II toxin-antitoxin system PemK/MazF family toxin	-
E0E12_RS11455	-	2162186..2163223 (+)	1038	WP_000857198.1	tyrosine-type recombinase/integrase	-
E0E12_RS11460	sph	2163280..2164104 (+)	825	Protein_2123	sphingomyelin phosphodiesterase	-
E0E12_RS11465	lukG	2164342..2165358 (-)	1017	WP_000595323.1	bi-component leukocidin LukGH subunit G	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 26769.35 Da
• Isoelectric Point: 5.4082

>NTDB_id=993326 E0E12_RS11435 WP_000094093.1 2159921..2160628(+) (irvR) [Staphylococcus aureus strain JKD6009 isolate JKD6009]
MSSFSSNLERLMNKRDMSDSELAELVDVNRTTVTRWRKGIRSPKLDKLPEIANVFGVKPLDLIHDMDDSKIIEEIHNVSS
QLTPPRQSNVLKYATNQLEEQNNDSDNLVDFNSYIQEKSEVDIYGCASAGIGERLYNEPISKEFVRGYVPAHDIALKVNG
DSMEPLFKNGQIIFIEKSHTIKDGQIGVFIINGDAYVKKVYVEDNRLTLVSLNKKYKDLHFYDNESVRLVGKVIL

Nucleotide

• Length: 708 bp

>NTDB_id=993326 E0E12_RS11435 WP_000094093.1 2159921..2160628(+) (irvR) [Staphylococcus aureus strain JKD6009 isolate JKD6009]
ATGAGTTCATTTTCTTCGAATTTAGAACGTCTGATGAACAAAAGAGATATGAGTGATAGTGAATTAGCAGAATTAGTAGA
TGTTAATAGAACAACAGTCACAAGATGGAGAAAGGGAATTAGAAGTCCAAAACTAGATAAATTACCTGAAATAGCTAATG
TTTTTGGAGTTAAACCCTTAGATTTAATACATGATATGGATGATTCGAAAATTATTGAAGAAATTCATAACGTATCATCT
CAACTCACGCCTCCAAGACAAAGCAATGTACTAAAATATGCGACTAATCAATTAGAAGAGCAAAATAATGACAGTGATAA
TCTGGTAGATTTCAATTCTTACATTCAAGAAAAATCCGAAGTGGATATATATGGTTGTGCGTCTGCTGGTATTGGTGAAA
GATTATATAACGAGCCTATTTCAAAAGAATTCGTAAGAGGTTATGTCCCCGCACATGATATAGCTTTAAAAGTAAATGGA
GACTCAATGGAGCCGTTATTTAAAAATGGACAAATTATATTCATTGAAAAATCTCACACTATCAAAGATGGACAAATAGG
CGTCTTTATTATAAATGGAGATGCTTACGTAAAGAAGGTTTATGTAGAAGATAACAGATTAACGTTGGTTTCTTTAAATA
AAAAGTATAAAGATTTACATTTTTATGATAATGAAAGTGTGAGGTTAGTTGGAAAAGTTATTTTATAG

Domains

Predicted by InterProScan.

• Peptidase S24-like (Peptidase_S24) (123-234)

• Helix-turn-helix (HTH_3) (8-61)

3D structure

• AlphaFold DB: A0A1D4DWM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
irvR	Streptococcus mutans UA159	30.769	100	0.374