Detailed information NTG0098940

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R8570_RS10825
• Genome accession: NZ_AP026932
• Coordinates: 2132966..2133718 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701549
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2127966..2138718

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8570_RS10805	-	2130294..2132002 (-)	1709	Protein_2091	YhgE/Pip family protein	-
R8570_RS10810 (PC1528_21200)	-	2132181..2132723 (+)	543	WP_001863823.1	TetR/AcrR family transcriptional regulator	-
R8570_RS10825 (PC1528_21210)	comE	2132966..2133718 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8570_RS10830 (PC1528_21220)	comD/comD2	2133715..2135040 (-)	1326	WP_000364846.1	competence system sensor histidine kinase ComD	Regulator
R8570_RS10835	comC/comC2	2135061..2135186 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
R8570_RS10845 (PC1528_21230)	rlmH	2135468..2135947 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8570_RS10850 (PC1528_21240)	htrA	2136130..2137311 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
R8570_RS10855 (PC1528_21250)	spo0J	2137369..2138127 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=98940 R8570_RS10825 WP_000866065.1 2132966..2133718(-) (comE) [Streptococcus pneumoniae strain PZ900701549]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=98940 R8570_RS10825 WP_000866065.1 2132966..2133718(-) (comE) [Streptococcus pneumoniae strain PZ900701549]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408