Detailed information NTG0098331

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8507_RS02425
• Genome accession: NZ_AP026925
• Coordinates: 467996..468733 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain PZ900700097
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 462996..473733

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8507_RS02390 (PC0094_04700)	-	463927..464166 (-)	240	WP_001813906.1	hypothetical protein	-
R8507_RS02395 (PC0094_04710)	-	464328..464615 (-)	288	WP_000777760.1	hypothetical protein	-
R8507_RS02400 (PC0094_04720)	-	464625..465035 (-)	411	WP_001278301.1	HIT family protein	-
R8507_RS02405 (PC0094_04730)	pptA	465103..465834 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
R8507_RS02410 (PC0094_04740)	-	465831..466880 (+)	1050	WP_000653752.1	ABC transporter permease	-
R8507_RS02415 (PC0094_04750)	-	467048..467377 (-)	330	WP_000132575.1	hypothetical protein	-
R8507_RS02420 (PC0094_04760)	-	467653..467991 (+)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
R8507_RS02425 (PC0094_04770)	comE/blpR	467996..468733 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
R8507_RS02430 (PC0094_04780)	-	468746..470086 (+)	1341	WP_317643596.1	sensor histidine kinase	-
R8507_RS02435 (PC0094_04790)	blpC	470157..470285 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8507_RS02440 (PC0094_04800)	-	470342..471703 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8507_RS02445 (PC0094_04810)	comA/nlmT	471792..473390 (-)	1599	WP_317643771.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=98331 R8507_RS02425 WP_001219126.1 467996..468733(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700097]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=98331 R8507_RS02425 WP_001219126.1 467996..468733(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700097]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384