Detailed information
Bioinformatically predicted
Overview
| Name | clpX | Type | Regulator |
| Locus tag | R8635_RS03435 | Genome accession | NZ_AP026924 |
| Coordinates | 661382..662614 (+) | Length | 410 a.a. |
| NCBI ID | WP_000106346.1 | Uniprot ID | A0A064C077 |
| Organism | Streptococcus pneumoniae strain PZ900700063 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 660674..710641 | 661382..662614 | within | 0 |
Gene organization within MGE regions
Location: 660674..710641
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R8635_RS03425 (PC0062_06730) | - | 660674..661180 (+) | 507 | WP_000162484.1 | dihydrofolate reductase | - |
| R8635_RS03430 | - | 661180..661350 (+) | 171 | WP_000442275.1 | hypothetical protein | - |
| R8635_RS03435 (PC0062_06740) | clpX | 661382..662614 (+) | 1233 | WP_000106346.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | Regulator |
| R8635_RS03440 (PC0062_06750) | yihA | 662623..663210 (+) | 588 | WP_000422599.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
| R8635_RS03445 (PC0062_06760) | - | 663221..663601 (+) | 381 | WP_001140413.1 | RidA family protein | - |
| R8635_RS03450 (PC0062_06770) | rapZ | 663653..664543 (+) | 891 | WP_000163035.1 | RNase adapter RapZ | - |
| R8635_RS03455 (PC0062_06780) | - | 664540..665517 (+) | 978 | WP_001231086.1 | YvcK family protein | - |
| R8635_RS03460 (PC0062_06790) | whiA | 665514..666416 (+) | 903 | WP_317657553.1 | DNA-binding protein WhiA | - |
| R8635_RS03465 (PC0062_06800) | - | 666511..667638 (-) | 1128 | WP_000266847.1 | site-specific integrase | - |
| R8635_RS03470 (PC0062_06810) | - | 667780..668160 (-) | 381 | WP_000151193.1 | ImmA/IrrE family metallo-endopeptidase | - |
| R8635_RS03475 (PC0062_06820) | - | 668181..668660 (-) | 480 | WP_001113481.1 | hypothetical protein | - |
| R8635_RS03480 (PC0062_06830) | - | 668664..669086 (-) | 423 | WP_000181886.1 | hypothetical protein | - |
| R8635_RS03485 (PC0062_06840) | - | 669088..669441 (-) | 354 | WP_050219618.1 | helix-turn-helix domain-containing protein | - |
| R8635_RS03490 (PC0062_06860) | - | 669856..670095 (-) | 240 | WP_000142893.1 | hypothetical protein | - |
| R8635_RS03495 (PC0062_06870) | - | 670160..670351 (+) | 192 | WP_001112859.1 | DNA-binding protein | - |
| R8635_RS03500 (PC0062_06890) | - | 670465..670686 (-) | 222 | WP_000041096.1 | hypothetical protein | - |
| R8635_RS03505 (PC0062_06900) | - | 670804..670947 (+) | 144 | WP_000389583.1 | hypothetical protein | - |
| R8635_RS03510 (PC0062_06910) | - | 671029..671301 (+) | 273 | WP_000388508.1 | hypothetical protein | - |
| R8635_RS03515 (PC0062_06920) | - | 671298..671492 (+) | 195 | WP_001050924.1 | hypothetical protein | - |
| R8635_RS03520 (PC0062_06930) | - | 671489..671680 (+) | 192 | WP_000970850.1 | hypothetical protein | - |
| R8635_RS03525 (PC0062_06940) | - | 671692..672033 (+) | 342 | WP_000189401.1 | hypothetical protein | - |
| R8635_RS03530 (PC0062_06950) | - | 672034..672264 (+) | 231 | WP_000252079.1 | hypothetical protein | - |
| R8635_RS03535 (PC0062_06960) | - | 672278..673000 (+) | 723 | WP_001861572.1 | HNH endonuclease signature motif containing protein | - |
| R8635_RS03540 (PC0062_06970) | - | 672993..673475 (+) | 483 | WP_000157808.1 | siphovirus Gp157 family protein | - |
| R8635_RS03545 (PC0062_06980) | - | 673475..673834 (+) | 360 | WP_000422309.1 | hypothetical protein | - |
| R8635_RS03550 (PC0062_06990) | - | 673834..674319 (+) | 486 | WP_000696056.1 | hypothetical protein | - |
| R8635_RS03555 (PC0062_07000) | - | 674282..675475 (+) | 1194 | WP_000028860.1 | DEAD/DEAH box helicase family protein | - |
| R8635_RS03560 (PC0062_07010) | - | 675494..675811 (+) | 318 | WP_001044592.1 | hypothetical protein | - |
| R8635_RS03565 (PC0062_07020) | - | 675811..676638 (+) | 828 | WP_000885997.1 | AAA family ATPase | - |
| R8635_RS03570 (PC0062_07030) | - | 676658..677164 (+) | 507 | WP_000054340.1 | hypothetical protein | - |
| R8635_RS03575 (PC0062_07050) | - | 677337..678158 (+) | 822 | WP_025173152.1 | bifunctional DNA primase/polymerase | - |
| R8635_RS03580 (PC0062_07060) | - | 678161..679504 (+) | 1344 | WP_050201966.1 | virulence-associated E family protein | - |
| R8635_RS03585 (PC0062_07070) | - | 679798..679950 (+) | 153 | WP_000122746.1 | hypothetical protein | - |
| R8635_RS03590 (PC0062_07080) | - | 679950..680288 (+) | 339 | WP_050144716.1 | hypothetical protein | - |
| R8635_RS03595 (PC0062_07100) | - | 680439..680753 (+) | 315 | WP_050144714.1 | hypothetical protein | - |
| R8635_RS03600 (PC0062_07110) | - | 680755..681285 (+) | 531 | WP_001021766.1 | DUF1642 domain-containing protein | - |
| R8635_RS03605 (PC0062_07120) | - | 681285..681512 (+) | 228 | WP_050144709.1 | hypothetical protein | - |
| R8635_RS03610 (PC0062_07130) | - | 681613..681933 (+) | 321 | WP_055386256.1 | hypothetical protein | - |
| R8635_RS03615 (PC0062_07140) | - | 681930..682301 (+) | 372 | WP_050144707.1 | hypothetical protein | - |
| R8635_RS03620 (PC0062_07150) | - | 682372..682806 (+) | 435 | WP_001030239.1 | DUF1492 domain-containing protein | - |
| R8635_RS03630 (PC0062_07160) | - | 683299..683739 (+) | 441 | WP_001859583.1 | terminase small subunit | - |
| R8635_RS03635 (PC0062_07170) | - | 683717..685015 (+) | 1299 | WP_219576686.1 | PBSX family phage terminase large subunit | - |
| R8635_RS03640 (PC0062_07180) | - | 685027..686496 (+) | 1470 | WP_078139444.1 | phage portal protein | - |
| R8635_RS03645 (PC0062_07190) | - | 686405..688042 (+) | 1638 | WP_179855908.1 | minor capsid protein | - |
| R8635_RS03650 (PC0062_07200) | - | 688044..688253 (+) | 210 | WP_000651746.1 | hypothetical protein | - |
| R8635_RS03655 (PC0062_07210) | - | 688250..688663 (+) | 414 | WP_050199672.1 | HD domain-containing protein | - |
| R8635_RS03660 (PC0062_07220) | - | 688706..688993 (+) | 288 | WP_001046058.1 | hypothetical protein | - |
| R8635_RS03665 (PC0062_07240) | - | 689134..689346 (+) | 213 | WP_317657554.1 | crAss001_48 related protein | - |
| R8635_RS03670 (PC0062_07250) | - | 689516..690040 (+) | 525 | WP_001288019.1 | DUF4355 domain-containing protein | - |
| R8635_RS03675 (PC0062_07260) | - | 690063..691088 (+) | 1026 | WP_024478503.1 | carbohydrate-binding protein | - |
| R8635_RS03680 (PC0062_07270) | - | 691098..691286 (+) | 189 | WP_050141951.1 | hypothetical protein | - |
| R8635_RS03685 (PC0062_07280) | - | 691288..691599 (+) | 312 | WP_050219612.1 | phage head-tail connector protein | - |
| R8635_RS03690 (PC0062_07290) | - | 691580..691918 (+) | 339 | WP_050201113.1 | hypothetical protein | - |
| R8635_RS03695 (PC0062_07300) | - | 691893..692408 (+) | 516 | WP_001862992.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| R8635_RS03700 (PC0062_07310) | - | 692405..692773 (+) | 369 | WP_000608235.1 | hypothetical protein | - |
| R8635_RS03705 (PC0062_07320) | - | 692776..693189 (+) | 414 | WP_000880666.1 | phage tail tube protein | - |
| R8635_RS03710 (PC0062_07330) | - | 693194..693574 (+) | 381 | WP_001185631.1 | DUF6096 family protein | - |
| R8635_RS03715 (PC0062_07340) | - | 693613..693963 (+) | 351 | WP_000478007.1 | hypothetical protein | - |
| R8635_RS03720 (PC0062_07350) | - | 693950..697603 (+) | 3654 | WP_317657555.1 | hypothetical protein | - |
| R8635_RS03725 (PC0062_07360) | - | 697612..697962 (+) | 351 | WP_221014202.1 | DUF6711 family protein | - |
| R8635_RS03730 (PC0062_07370) | - | 699350..705289 (+) | 5940 | WP_408669696.1 | tail fiber domain-containing protein | - |
| R8635_RS03735 | - | 705286..705402 (+) | 117 | WP_001063633.1 | hypothetical protein | - |
| R8635_RS03740 (PC0062_07380) | - | 705383..705586 (+) | 204 | WP_054373880.1 | hypothetical protein | - |
| R8635_RS03745 (PC0062_07390) | - | 705589..705939 (+) | 351 | WP_000852248.1 | hypothetical protein | - |
| R8635_RS03750 (PC0062_07400) | - | 705949..706365 (+) | 417 | WP_001165341.1 | phage holin family protein | - |
| R8635_RS03755 (PC0062_07410) | - | 706369..706701 (+) | 333 | WP_001186238.1 | phage holin | - |
| R8635_RS03760 (PC0062_07420) | - | 706705..707661 (+) | 957 | WP_317657557.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| R8635_RS03765 (PC0062_07430) | - | 707914..708882 (-) | 969 | WP_000081002.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| R8635_RS03770 (PC0062_07440) | cdaA | 709018..709875 (+) | 858 | WP_001011063.1 | diadenylate cyclase CdaA | - |
| R8635_RS03775 (PC0062_07450) | - | 709862..710641 (+) | 780 | WP_000742290.1 | YbbR-like domain-containing protein | - |
Sequence
Protein
Download Length: 410 a.a. Molecular weight: 45798.35 Da Isoelectric Point: 4.4550
>NTDB_id=98251 R8635_RS03435 WP_000106346.1 661382..662614(+) (clpX) [Streptococcus pneumoniae strain PZ900700063]
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
Nucleotide
Download Length: 1233 bp
>NTDB_id=98251 R8635_RS03435 WP_000106346.1 661382..662614(+) (clpX) [Streptococcus pneumoniae strain PZ900700063]
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAACCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTACCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTACCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATCATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTCGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAACCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTACCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTACCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATCATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTCGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpX | Streptococcus mutans UA159 |
86.585 |
100 |
0.866 |
| clpX | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
57.214 |
98.049 |
0.561 |