Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   R8566_RS02715 Genome accession   NZ_AP026920
Coordinates   533053..535206 (-) Length   717 a.a.
NCBI ID   WP_000205159.1    Uniprot ID   G3EBW0
Organism   Streptococcus pneumoniae strain PZ900700014     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 528053..540206
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8566_RS02685 (PC0014_05310) - 528385..528714 (-) 330 WP_000132583.1 hypothetical protein -
  R8566_RS02690 (PC0014_05320) - 528991..529329 (+) 339 WP_000682136.1 LytTR family DNA-binding domain-containing protein -
  R8566_RS02695 (PC0014_05330) comE/blpR 529334..530071 (+) 738 WP_001219134.1 LytTR family DNA-binding domain-containing protein Regulator
  R8566_RS02700 (PC0014_05340) - 530085..531425 (+) 1341 WP_001099894.1 sensor histidine kinase -
  R8566_RS02705 (PC0014_05350) blpC 531469..531624 (-) 156 WP_000358812.1 quorum-sensing system pheromone BlpC -
  R8566_RS02710 (PC0014_05360) - 531681..533042 (-) 1362 WP_001069062.1 bacteriocin secretion accessory protein -
  R8566_RS02715 (PC0014_05370) comA/nlmT 533053..535206 (-) 2154 WP_000205159.1 peptide cleavage/export ABC transporter BlpA Regulator
  R8566_RS02720 (PC0014_05380) - 535487..535690 (+) 204 WP_001093262.1 bacteriocin class II family protein -
  R8566_RS02725 (PC0014_05390) - 536008..536211 (+) 204 WP_000411016.1 hypothetical protein -
  R8566_RS02730 - 537214..538018 (+) 805 Protein_538 IS5 family transposase -
  R8566_RS02735 (PC0014_05430) blpM 538171..538425 (+) 255 WP_000379878.1 two-peptide bacteriocin subunit BlpM -
  R8566_RS02740 (PC0014_05440) blpN 538441..538644 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  R8566_RS02745 (PC0014_05450) - 538888..539121 (+) 234 WP_000379963.1 hypothetical protein -
  R8566_RS02750 (PC0014_05460) - 539153..539842 (+) 690 WP_000760523.1 CPBP family intramembrane glutamic endopeptidase -
  R8566_RS02755 (PC0014_05470) blpZ 539884..540117 (+) 234 WP_000276498.1 immunity protein BlpZ -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80835.85 Da        Isoelectric Point: 7.6610

>NTDB_id=97939 R8566_RS02715 WP_000205159.1 533053..535206(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700014]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINYQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=97939 R8566_RS02715 WP_000205159.1 533053..535206(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700014]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTTTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTCG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATTATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAATTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATCCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGCTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(169-438)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G3EBW0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.168

99.721

0.72
  comA Streptococcus mitis NCTC 12261

66.62

99.442

0.662
  comA Streptococcus pneumoniae Rx1

66.339

99.442

0.66
  comA Streptococcus pneumoniae D39

66.339

99.442

0.66
  comA Streptococcus pneumoniae R6

66.339

99.442

0.66
  comA Streptococcus mitis SK321

66.059

99.442

0.657
  comA Streptococcus pneumoniae TIGR4

66.059

99.442

0.657
  comA Streptococcus gordonii str. Challis substr. CH1

65.32

100

0.654

Multiple sequence alignment