Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R8566_RS02695 Genome accession   NZ_AP026920
Coordinates   529334..530071 (+) Length   245 a.a.
NCBI ID   WP_001219134.1    Uniprot ID   A0A0T9H772
Organism   Streptococcus pneumoniae strain PZ900700014     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 524334..535071
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8566_RS02660 - 525327..525503 (-) 177 WP_001811606.1 hypothetical protein -
  R8566_RS02665 (PC0014_05270) - 525665..525952 (-) 288 WP_000777760.1 hypothetical protein -
  R8566_RS02670 (PC0014_05280) - 525962..526372 (-) 411 WP_001278304.1 HIT family protein -
  R8566_RS02675 (PC0014_05290) pptA 526440..527171 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  R8566_RS02680 (PC0014_05300) - 527168..528217 (+) 1050 WP_000653768.1 ABC transporter permease -
  R8566_RS02685 (PC0014_05310) - 528385..528714 (-) 330 WP_000132583.1 hypothetical protein -
  R8566_RS02690 (PC0014_05320) - 528991..529329 (+) 339 WP_000682136.1 LytTR family DNA-binding domain-containing protein -
  R8566_RS02695 (PC0014_05330) comE/blpR 529334..530071 (+) 738 WP_001219134.1 LytTR family DNA-binding domain-containing protein Regulator
  R8566_RS02700 (PC0014_05340) - 530085..531425 (+) 1341 WP_001099894.1 sensor histidine kinase -
  R8566_RS02705 (PC0014_05350) blpC 531469..531624 (-) 156 WP_000358812.1 quorum-sensing system pheromone BlpC -
  R8566_RS02710 (PC0014_05360) - 531681..533042 (-) 1362 WP_001069062.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28802.93 Da        Isoelectric Point: 6.2366

>NTDB_id=97938 R8566_RS02695 WP_001219134.1 529334..530071(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700014]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRFLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=97938 R8566_RS02695 WP_001219134.1 529334..530071(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700014]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
TTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTTTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T9H772

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.036

100

0.535
  comE/comE1 Streptococcus equinus JB1

42.616

96.735

0.412
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376

Multiple sequence alignment