Detailed information NTG0097874

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: R8613_RS06515
• Genome accession: NZ_AP026919
• Coordinates: 1255024..1255761 (-)
• Length: 245 a.a.
• NCBI ID: WP_000782676.1
• Uniprot ID: A0A064C3U8
• Organism: Streptococcus pneumoniae strain PZ900700012
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1256046..1257302	1255024..1255761	flank	285

Gene organization within MGE regions

Location: 1255024..1257302

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8613_RS06515 (PC0012_12620)	mecA	1255024..1255761 (-)	738	WP_000782676.1	adaptor protein MecA	Regulator
R8613_RS06520 (PC0012_12630)	-	1256046..1257302 (+)	1257	WP_317648101.1	ISL3 family transposase	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28381.18 Da
• Isoelectric Point: 4.0199

>NTDB_id=97874 R8613_RS06515 WP_000782676.1 1255024..1255761(-) (mecA) [Streptococcus pneumoniae strain PZ900700012]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide

• Length: 738 bp

>NTDB_id=97874 R8613_RS06515 WP_000782676.1 1255024..1255761(-) (mecA) [Streptococcus pneumoniae strain PZ900700012]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTAGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-239)

3D structure

• AlphaFold DB: A0A064C3U8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus pneumoniae Rx1	99.592	100	0.996
mecA	Streptococcus pneumoniae D39	99.592	100	0.996
mecA	Streptococcus pneumoniae R6	99.592	100	0.996
mecA	Streptococcus pneumoniae TIGR4	99.184	100	0.992
mecA	Streptococcus thermophilus LMD-9	47.791	100	0.486
mecA	Streptococcus thermophilus LMG 18311	47.39	100	0.482
mecA	Streptococcus mutans UA159	48.163	100	0.482