Detailed information NTG0978502

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS37642_RS06460
• Genome accession: NZ_CP151468
• Coordinates: 1250062..1251099 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS37642
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1245062..1256099

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37642_RS06440 (MGAS37642_02642)	-	1245813..1246439 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS37642_RS06445 (MGAS37642_02644)	rlmN	1246521..1247600 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS37642_RS06450 (MGAS37642_02646)	-	1247604..1248224 (-)	621	WP_011285637.1	YutD family protein	-
MGAS37642_RS06455 (MGAS37642_02648)	-	1248672..1249648 (-)	977	Protein_1213	LacI family DNA-binding transcriptional regulator	-
MGAS37642_RS06460 (MGAS37642_02652)	sepM	1250062..1251099 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS37642_RS06465 (MGAS37642_02654)	coaD	1251086..1251577 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS37642_RS06470 (MGAS37642_02656)	rsmD	1251567..1252106 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS37642_RS06475 (MGAS37642_02658)	asnA	1252229..1253221 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS37642_RS06480 (MGAS37642_02660)	arcC	1253534..1254484 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS37642_RS06485 (MGAS37642_02662)	-	1254504..1255835 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=978502 MGAS37642_RS06460 WP_010922499.1 1250062..1251099(-) (sepM) [Streptococcus pyogenes strain MGAS37642]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=978502 MGAS37642_RS06460 WP_010922499.1 1250062..1251099(-) (sepM) [Streptococcus pyogenes strain MGAS37642]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693