Detailed information NTG0097680

Bioinformatically predicted

Overview

• Name: comD/comD2
• Type: Regulator
• Locus tag: R8522_RS11105
• Genome accession: NZ_AP026916
• Coordinates: 2157324..2158622 (+)
• Length: 432 a.a.
• NCBI ID: WP_061372803.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700006
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2156358..2157311	2157324..2158622	flank	13

Gene organization within MGE regions

Location: 2156358..2158622

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8522_RS11100 (PC0006_21990)	-	2156358..2157311 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
R8522_RS11105	comD/comD2	2157324..2158622 (+)	1299	WP_061372803.1	competence system sensor histidine kinase ComD	Regulator

Sequence

Protein

• Length: 432 a.a.
• Molecular weight: 50600.01 Da
• Isoelectric Point: 7.5553

>NTDB_id=97680 R8522_RS11105 WP_061372803.1 2157324..2158622(+) (comD/comD2) [Streptococcus pneumoniae strain PZ900700006]
MWDFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQYERDRGLFLS
LLLSLLYESTHNFLSVIFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKKVFFALLLLH
IVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLYNEIRGFRHD
YAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTLEVKDTIT
KLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFSLGFSTKGRNRGVGLNNV
KELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1299 bp

>NTDB_id=97680 R8522_RS11105 WP_061372803.1 2157324..2158622(+) (comD/comD2) [Streptococcus pneumoniae strain PZ900700006]
ATTTGGGATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCGAATAAATAGAAAAGAATTATACGTTTT
TGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTCTATATTTAGATAAAATAGGGATTGAAA
GATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTATGAGAGGGATAGAGGACTATTCCTAAGT
TTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAATTTTCTCCTCTATAACAGGAGATAATTTTGT
TTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTGTTACATTAAAAATCATTTACTATTTCC
ATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAAGTATTTTTTGCTTTACTATTGCTACAT
ATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTTTGGAAGTATTTTGTCATCTATTGTCTT
TATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGGAGAAAGAGATTGCTTTGAAGCAGAAGA
AATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTATAATGAAATCCGTGGTTTTCGACATGAT
TATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACAGGAAATTGACAGAATTTACAATGAAGT
TTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATTTGAACAACATAGAAGACTCAGCTTTAC
GAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTTACACTGGAAGTAAAAGATACGATTACC
AAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAATAATGCTGTCGAAGGATCGGCTGATAG
CTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTATTGTGATTCAGAATTCATGTAAAATGA
CGATGACTCCTTCAGGAGATCTATTTTCCTTAGGATTCTCCACTAAGGGAAGAAATCGCGGAGTCGGATTAAATAATGTG
AAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGGCAGTACATTTAGACAAATCATTAGATT
TAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (325-425)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD2	Streptococcus pneumoniae TIGR4	99.767	99.306	0.991
comD/comD1	Streptococcus pneumoniae Rx1	96.737	99.306	0.961
comD/comD1	Streptococcus pneumoniae D39	96.737	99.306	0.961
comD/comD1	Streptococcus pneumoniae R6	96.737	99.306	0.961
comD	Streptococcus mitis SK321	92.774	99.306	0.921
comD	Streptococcus mitis NCTC 12261	87.822	98.843	0.868
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.733	86.574	0.431
comD/comD2	Streptococcus gordonii strain NCTC7865	49.468	87.037	0.431