Detailed information NTG0976767

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS38345_RS06400
• Genome accession: NZ_CP151437
• Coordinates: 1244082..1245119 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS38345
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1239082..1250119

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS38345_RS06380 (MGAS38345_02614)	-	1239833..1240459 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS38345_RS06385 (MGAS38345_02616)	rlmN	1240541..1241620 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS38345_RS06390 (MGAS38345_02618)	-	1241624..1242244 (-)	621	WP_011285637.1	YutD family protein	-
MGAS38345_RS06395 (MGAS38345_02620)	-	1242692..1243668 (-)	977	Protein_1214	LacI family DNA-binding transcriptional regulator	-
MGAS38345_RS06400 (MGAS38345_02624)	sepM	1244082..1245119 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS38345_RS06405 (MGAS38345_02626)	coaD	1245106..1245597 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS38345_RS06410 (MGAS38345_02628)	rsmD	1245587..1246126 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS38345_RS06415 (MGAS38345_02630)	asnA	1246249..1247241 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS38345_RS06420 (MGAS38345_02632)	arcC	1247554..1248504 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS38345_RS06425 (MGAS38345_02634)	-	1248524..1249855 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=976767 MGAS38345_RS06400 WP_010922499.1 1244082..1245119(-) (sepM) [Streptococcus pyogenes strain MGAS38345]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=976767 MGAS38345_RS06400 WP_010922499.1 1244082..1245119(-) (sepM) [Streptococcus pyogenes strain MGAS38345]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693