Detailed information NTG0097497

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8474_RS07685
• Genome accession: NZ_AP026914
• Coordinates: 1516846..1517583 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain PZ900700003
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1511846..1522583

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8474_RS07665 (PC0003_15200)	-	1512221..1513864 (+)	1644	Protein_1518	peptide cleavage/export ABC transporter	-
R8474_RS07670 (PC0003_15220)	-	1513875..1515236 (+)	1362	WP_317641666.1	bacteriocin secretion accessory protein	-
R8474_RS07675 (PC0003_15230)	blpC	1515293..1515421 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8474_RS07680 (PC0003_15240)	-	1515492..1516832 (-)	1341	WP_001017646.1	sensor histidine kinase	-
R8474_RS07685 (PC0003_15250)	comE/blpR	1516846..1517583 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
R8474_RS07690 (PC0003_15260)	-	1517588..1517926 (-)	339	WP_317641671.1	LytTR family DNA-binding domain-containing protein	-
R8474_RS07695 (PC0003_15270)	-	1518202..1518531 (+)	330	WP_000132567.1	hypothetical protein	-
R8474_RS07700 (PC0003_15280)	-	1518699..1519748 (-)	1050	WP_317641679.1	ABC transporter permease	-
R8474_RS07705 (PC0003_15290)	pptA	1519745..1520476 (-)	732	WP_317641681.1	ABC transporter ATP-binding protein	Regulator
R8474_RS07710 (PC0003_15300)	-	1520544..1520954 (+)	411	WP_001278301.1	HIT family protein	-
R8474_RS07715 (PC0003_15310)	-	1520964..1521251 (+)	288	WP_268217887.1	hypothetical protein	-
R8474_RS07720 (PC0003_15320)	-	1521413..1521697 (+)	285	WP_050150649.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=97497 R8474_RS07685 WP_001219120.1 1516846..1517583(-) (comE/blpR) [Streptococcus pneumoniae strain PZ900700003]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=97497 R8474_RS07685 WP_001219120.1 1516846..1517583(-) (comE/blpR) [Streptococcus pneumoniae strain PZ900700003]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363