Detailed information NTG0972370

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC62_RS12690
• Genome accession: NZ_CP150773
• Coordinates: 2556115..2557158 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20913
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2551115..2562158

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC62_RS12660 (WOC62_12655)	-	2551481..2551592 (+)	112	Protein_2489	hypothetical protein	-
WOC62_RS12665 (WOC62_12660)	-	2551621..2552034 (+)	414	WP_001837236.1	hypothetical protein	-
WOC62_RS12670 (WOC62_12665)	-	2552524..2553510 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC62_RS12675 (WOC62_12670)	map	2554041..2554799 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC62_RS12680 (WOC62_12675)	-	2555016..2555402 (+)	387	WP_001110179.1	hypothetical protein	-
WOC62_RS12685 (WOC62_12680)	liaF	2555417..2556118 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC62_RS12690 (WOC62_12685)	vraS	2556115..2557158 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC62_RS12695 (WOC62_12690)	vraR	2557148..2557777 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC62_RS12700 (WOC62_12695)	-	2557889..2559100 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
WOC62_RS12705 (WOC62_12700)	-	2559378..2559653 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC62_RS12710 (WOC62_12705)	-	2559660..2560124 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC62_RS12715 (WOC62_12710)	-	2560271..2560471 (+)	201	WP_000180460.1	DUF1128 family protein	-
WOC62_RS12720 (WOC62_12715)	-	2560474..2561730 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972370 WOC62_RS12690 WP_001017131.1 2556115..2557158(+) (vraS) [Staphylococcus aureus strain TUM20913]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972370 WOC62_RS12690 WP_001017131.1 2556115..2557158(+) (vraS) [Staphylococcus aureus strain TUM20913]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1