Detailed information NTG0972154

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC63_RS11320
• Genome accession: NZ_CP150765
• Coordinates: 2297878..2298921 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20963
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2292878..2303921

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC63_RS11290 (WOC63_11285)	-	2293296..2294552 (-)	1257	WP_001795438.1	aminopeptidase	-
WOC63_RS11295 (WOC63_11290)	-	2294555..2294755 (-)	201	WP_000180461.1	DUF1128 family protein	-
WOC63_RS11300 (WOC63_11295)	-	2294902..2295366 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC63_RS11305 (WOC63_11300)	-	2295373..2295648 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC63_RS11310 (WOC63_11305)	-	2295926..2297143 (+)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
WOC63_RS11315 (WOC63_11310)	vraR	2297259..2297888 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
WOC63_RS11320 (WOC63_11315)	vraS	2297878..2298921 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC63_RS11325 (WOC63_11320)	liaF	2298918..2299619 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC63_RS11330 (WOC63_11325)	-	2299634..2300020 (-)	387	WP_001110179.1	hypothetical protein	-
WOC63_RS11335 (WOC63_11330)	map	2300237..2300995 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC63_RS11340 (WOC63_11335)	-	2301582..2302568 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC63_RS11345 (WOC63_11340)	-	2303058..2303471 (-)	414	WP_001549145.1	hypothetical protein	-
WOC63_RS11350 (WOC63_11345)	-	2303500..2303610 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972154 WOC63_RS11320 WP_001017131.1 2297878..2298921(-) (vraS) [Staphylococcus aureus strain TUM20963]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972154 WOC63_RS11320 WP_001017131.1 2297878..2298921(-) (vraS) [Staphylococcus aureus strain TUM20963]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1