Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   WOC45_RS08880 Genome accession   NZ_CP150752
Coordinates   1760965..1762593 (-) Length   542 a.a.
NCBI ID   WP_406822339.1    Uniprot ID   -
Organism   Staphylococcus aureus strain TUM22458     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 1714428..1763964 1760965..1762593 within 0


Gene organization within MGE regions


Location: 1714428..1763964
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WOC45_RS08650 (WOC45_08655) ccrC 1714428..1716107 (+) 1680 WP_368409903.1 cassette chromosome recombinase CcrC -
  WOC45_RS08655 (WOC45_08660) - 1716196..1716534 (+) 339 WP_032604336.1 SAUGI family uracil-DNA glycosylase inhibitor -
  WOC45_RS08660 (WOC45_08665) - 1716628..1716939 (+) 312 WP_032604337.1 DUF960 family protein -
  WOC45_RS08665 (WOC45_08670) - 1716955..1717458 (+) 504 WP_002437518.1 DUF1643 domain-containing protein -
  WOC45_RS08670 (WOC45_08675) - 1717472..1717693 (+) 222 WP_002437519.1 hypothetical protein -
  WOC45_RS08675 (WOC45_08680) - 1717908..1718474 (+) 567 WP_002437520.1 hypothetical protein -
  WOC45_RS08680 (WOC45_08685) - 1718552..1721671 (-) 3120 WP_368409904.1 type I restriction endonuclease subunit R -
  WOC45_RS08685 (WOC45_08690) - 1721655..1722956 (-) 1302 WP_000456234.1 restriction endonuclease subunit S -
  WOC45_RS08690 (WOC45_08695) - 1722946..1724460 (-) 1515 WP_000190901.1 class I SAM-dependent DNA methyltransferase -
  WOC45_RS08695 (WOC45_08700) - 1724869..1726965 (+) 2097 WP_223200550.1 ATP-dependent endonuclease -
  WOC45_RS08700 (WOC45_08705) - 1726967..1728715 (+) 1749 WP_406818717.1 UvrD-helicase domain-containing protein -
  WOC45_RS08705 (WOC45_08710) - 1728925..1729107 (+) 183 Protein_1719 MFS transporter -
  WOC45_RS08710 (WOC45_08715) - 1729175..1730593 (-) 1419 WP_032605060.1 aspartate aminotransferase family protein -
  WOC45_RS08715 (WOC45_08720) - 1731544..1731711 (+) 168 WP_000669688.1 hypothetical protein -
  WOC45_RS08720 (WOC45_08725) - 1732186..1733442 (+) 1257 WP_000566670.1 MrcB family domain-containing protein -
  WOC45_RS08725 (WOC45_08730) - 1733857..1734096 (+) 240 WP_001282728.1 hypothetical protein -
  WOC45_RS08730 (WOC45_08735) - 1734128..1734802 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  WOC45_RS08735 (WOC45_08740) - 1734893..1735876 (-) 984 Protein_1725 protein rep -
  WOC45_RS08740 (WOC45_08745) mobV 1736121..1737374 (-) 1254 WP_368409905.1 MobV family relaxase -
  WOC45_RS08745 (WOC45_08750) bleO 1737880..1738284 (-) 405 WP_001242578.1 bleomycin binding protein -
  WOC45_RS08750 (WOC45_08755) aadD1 1738501..1739271 (-) 771 WP_001795128.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  WOC45_RS08755 (WOC45_08760) - 1739464..1740138 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  WOC45_RS08760 (WOC45_08765) - 1740222..1740563 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  WOC45_RS08765 (WOC45_08770) - 1741280..1742023 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  WOC45_RS08770 (WOC45_08775) - 1742120..1742548 (+) 429 WP_000872606.1 MaoC family dehydratase -
  WOC45_RS08775 (WOC45_08780) mecA 1742594..1744603 (-) 2010 WP_218089213.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  WOC45_RS08780 (WOC45_08785) mecR1 1744700..1746457 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  WOC45_RS08785 (WOC45_08790) mecI 1746457..1746828 (+) 372 WP_406818718.1 mecA-type methicillin resistance repressor MecI -
  WOC45_RS08790 (WOC45_08795) psm-mec 1746913..1746981 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  WOC45_RS08795 (WOC45_08800) - 1747336..1748445 (+) 1110 WP_000943131.1 ROK family transcriptional regulator -
  WOC45_RS08800 (WOC45_08805) cstB 1748559..1749896 (-) 1338 Protein_1738 persulfide dioxygenase-sulfurtransferase CstB -
  WOC45_RS08805 (WOC45_08810) - 1749929..1750995 (-) 1067 Protein_1739 DsrE/DsrF/DrsH-like family protein -
  WOC45_RS08810 (WOC45_08815) cstR 1751131..1751391 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  WOC45_RS08815 (WOC45_08820) - 1751391..1752029 (+) 639 Protein_1741 sulfite exporter TauE/SafE family protein -
  WOC45_RS08820 - 1752083..1752142 (-) 60 Protein_1742 DNA repair protein RadC -
  WOC45_RS08825 (WOC45_08825) - 1752374..1753036 (-) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  WOC45_RS08830 - 1753428..1753487 (+) 60 WP_010959190.1 erythromycin resistance leader peptide -
  WOC45_RS08835 (WOC45_08830) erm(A) 1753570..1754301 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  WOC45_RS08840 (WOC45_08835) - 1754427..1755209 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  WOC45_RS08845 (WOC45_08840) - 1755360..1755737 (-) 378 WP_000361059.1 DUF6262 family protein -
  WOC45_RS08850 (WOC45_08845) - 1755744..1757636 (-) 1893 WP_368409847.1 site-specific integrase -
  WOC45_RS08855 (WOC45_08850) - 1757633..1758718 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  WOC45_RS08860 (WOC45_08855) - 1758837..1759154 (-) 318 WP_000659050.1 JAB domain-containing protein -
  WOC45_RS08865 (WOC45_08860) - 1759175..1759681 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  WOC45_RS08870 (WOC45_08865) - 1759699..1760010 (-) 312 WP_000700853.1 DUF960 family protein -
  WOC45_RS08875 (WOC45_08870) - 1760097..1760447 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  WOC45_RS08880 (WOC45_08875) ccrB 1760965..1762593 (-) 1629 WP_406822339.1 cassette chromosome recombinase CcrB Machinery gene
  WOC45_RS08885 (WOC45_08880) ccrA 1762615..1763964 (-) 1350 WP_406822340.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62611.79 Da        Isoelectric Point: 9.7835

>NTDB_id=971841 WOC45_RS08880 WP_406822339.1 1760965..1762593(-) (ccrB) [Staphylococcus aureus strain TUM22458]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDCIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=971841 WOC45_RS08880 WP_406822339.1 1760965..1762593(-) (ccrB) [Staphylococcus aureus strain TUM22458]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATTGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

99.815

100

0.998

Multiple sequence alignment