Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | WOC69_RS08730 | Genome accession | NZ_CP150744 |
| Coordinates | 1775541..1776902 (-) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain TUM22702 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 1713849..1785230 | 1775541..1776902 | within | 0 |
Gene organization within MGE regions
Location: 1713849..1785230
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WOC69_RS08425 (WOC69_08425) | ccrA | 1713849..1715198 (+) | 1350 | WP_000815646.1 | recombinase family protein | Machinery gene |
| WOC69_RS08430 (WOC69_08430) | ccrB | 1715220..1716848 (+) | 1629 | WP_001186602.1 | recombinase family protein | Machinery gene |
| WOC69_RS08435 (WOC69_08435) | - | 1717366..1717716 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WOC69_RS08440 (WOC69_08440) | - | 1717803..1718114 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| WOC69_RS08445 (WOC69_08445) | - | 1718132..1718638 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| WOC69_RS08450 (WOC69_08450) | - | 1718659..1718976 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| WOC69_RS08455 (WOC69_08455) | - | 1719095..1720180 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| WOC69_RS08460 (WOC69_08460) | - | 1720177..1722069 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| WOC69_RS08465 (WOC69_08465) | - | 1722076..1722453 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| WOC69_RS08470 (WOC69_08470) | - | 1722604..1723386 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| WOC69_RS08475 (WOC69_08475) | erm(A) | 1723512..1724243 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| WOC69_RS08480 (WOC69_08480) | - | 1724777..1725439 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| WOC69_RS08485 (WOC69_08485) | - | 1725784..1726422 (-) | 639 | Protein_1672 | sulfite exporter TauE/SafE family protein | - |
| WOC69_RS08490 (WOC69_08490) | cstR | 1726422..1726682 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| WOC69_RS08495 (WOC69_08495) | - | 1726818..1727882 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| WOC69_RS08500 (WOC69_08500) | cstB | 1727915..1729249 (+) | 1335 | Protein_1675 | persulfide dioxygenase-sulfurtransferase CstB | - |
| WOC69_RS08505 (WOC69_08505) | - | 1729363..1730472 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| WOC69_RS08510 (WOC69_08510) | psm-mec | 1730827..1730895 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| WOC69_RS08515 (WOC69_08515) | mecI | 1730980..1731351 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| WOC69_RS08520 (WOC69_08520) | mecR1 | 1731351..1733108 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| WOC69_RS08525 (WOC69_08525) | mecA | 1733205..1735214 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| WOC69_RS08530 (WOC69_08530) | - | 1735260..1735688 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| WOC69_RS08535 (WOC69_08535) | - | 1735785..1736528 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| WOC69_RS08540 (WOC69_08540) | - | 1737365..1737754 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| WOC69_RS08545 (WOC69_08545) | - | 1737790..1738464 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| WOC69_RS08550 (WOC69_08550) | hutH | 1738584..1740098 (+) | 1515 | WP_000177465.1 | histidine ammonia-lyase | - |
| WOC69_RS08555 (WOC69_08555) | serS | 1740477..1741763 (+) | 1287 | WP_000884332.1 | serine--tRNA ligase | - |
| WOC69_RS08560 (WOC69_08560) | - | 1742414..1743109 (+) | 696 | WP_000190726.1 | AzlC family ABC transporter permease | - |
| WOC69_RS08565 (WOC69_08565) | - | 1743106..1743435 (+) | 330 | WP_000628051.1 | AzlD domain-containing protein | - |
| WOC69_RS08570 (WOC69_08570) | - | 1743798..1744766 (+) | 969 | WP_000186490.1 | alpha/beta fold hydrolase family protein | - |
| WOC69_RS08575 (WOC69_08575) | - | 1745059..1745997 (+) | 939 | WP_341262116.1 | YybS family protein | - |
| WOC69_RS08580 (WOC69_08580) | gdpP | 1746012..1747979 (+) | 1968 | WP_001081640.1 | cyclic-di-AMP phosphodiesterase GdpP | - |
| WOC69_RS08585 (WOC69_08585) | rplI | 1747976..1748422 (+) | 447 | WP_000864305.1 | 50S ribosomal protein L9 | - |
| WOC69_RS08590 (WOC69_08590) | dnaB | 1748454..1749854 (+) | 1401 | WP_000375647.1 | replicative DNA helicase | - |
| WOC69_RS08595 (WOC69_08595) | - | 1750132..1751415 (+) | 1284 | WP_000095328.1 | adenylosuccinate synthase | - |
| WOC69_RS08610 (WOC69_08610) | yycF | 1752618..1753319 (+) | 702 | WP_000101976.1 | response regulator YycF | - |
| WOC69_RS08615 (WOC69_08615) | walK | 1753332..1755158 (+) | 1827 | WP_000871607.1 | cell wall metabolism sensor histidine kinase WalK | - |
| WOC69_RS08620 (WOC69_08620) | yycH | 1755151..1756485 (+) | 1335 | WP_001060140.1 | two-component system activity regulator YycH | - |
| WOC69_RS08625 (WOC69_08625) | yycI | 1756486..1757274 (+) | 789 | WP_001104165.1 | two-component system regulatory protein YycI | - |
| WOC69_RS08630 (WOC69_08630) | - | 1757663..1758463 (+) | 801 | WP_000088649.1 | MBL fold metallo-hydrolase | - |
| WOC69_RS08635 (WOC69_08635) | adsA | 1758690..1761008 (+) | 2319 | WP_341262117.1 | LPXTG-anchored adenosine synthase AdsA | - |
| WOC69_RS08640 (WOC69_08640) | rlmH | 1761376..1761855 (+) | 480 | WP_000704775.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| WOC69_RS08645 (WOC69_08645) | - | 1761956..1762099 (+) | 144 | WP_001631028.1 | restriction endonuclease subunit R | - |
| WOC69_RS08650 (WOC69_08650) | - | 1762092..1763294 (+) | 1203 | WP_001631029.1 | restriction endonuclease subunit S | - |
| WOC69_RS08655 (WOC69_08655) | - | 1763339..1763555 (-) | 217 | Protein_1704 | IS5/IS1182 family transposase | - |
| WOC69_RS08660 (WOC69_08660) | - | 1763617..1764114 (-) | 498 | WP_001631030.1 | GNAT family N-acetyltransferase | - |
| WOC69_RS08665 (WOC69_08665) | - | 1764786..1765196 (-) | 411 | WP_001631031.1 | DUF2871 domain-containing protein | - |
| WOC69_RS08670 (WOC69_08670) | - | 1765359..1765579 (-) | 221 | Protein_1707 | hypothetical protein | - |
| WOC69_RS08675 (WOC69_08675) | - | 1765594..1766097 (-) | 504 | WP_001631032.1 | DUF1643 domain-containing protein | - |
| WOC69_RS08680 (WOC69_08680) | - | 1766113..1766352 (-) | 240 | Protein_1709 | DUF960 family protein | - |
| WOC69_RS08685 (WOC69_08685) | blaZ | 1766653..1767499 (-) | 847 | Protein_1710 | penicillin-hydrolyzing class A beta-lactamase BlaZ | - |
| WOC69_RS08690 (WOC69_08690) | blaR1 | 1767606..1769363 (+) | 1758 | WP_001096381.1 | beta-lactam sensor/signal transducer BlaR1 | - |
| WOC69_RS08695 (WOC69_08695) | blaI | 1769353..1769733 (+) | 381 | WP_000182645.1 | penicillinase repressor BlaI | - |
| WOC69_RS08700 (WOC69_08700) | - | 1769997..1770590 (+) | 594 | WP_000690638.1 | recombinase family protein | - |
| WOC69_RS08705 (WOC69_08705) | - | 1770562..1772004 (+) | 1443 | WP_002451367.1 | Mu transposase C-terminal domain-containing protein | - |
| WOC69_RS08710 (WOC69_08710) | - | 1771997..1772812 (+) | 816 | WP_000164963.1 | AAA family ATPase | - |
| WOC69_RS08715 (WOC69_08715) | - | 1772898..1772978 (-) | 81 | Protein_1716 | DUF960 family protein | - |
| WOC69_RS08720 (WOC69_08720) | - | 1773065..1773415 (-) | 351 | WP_001631034.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WOC69_RS08725 (WOC69_08725) | ccrB | 1773916..1775544 (-) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
| WOC69_RS08730 (WOC69_08730) | ccrA | 1775541..1776902 (-) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| WOC69_RS08735 (WOC69_08735) | - | 1777089..1777718 (-) | 630 | Protein_1720 | hypothetical protein | - |
| WOC69_RS08740 (WOC69_08740) | - | 1777727..1778065 (+) | 339 | Protein_1721 | recombinase family protein | - |
| WOC69_RS08745 (WOC69_08745) | - | 1778177..1778536 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| WOC69_RS08750 (WOC69_08750) | - | 1778743..1779069 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| WOC69_RS08755 (WOC69_08755) | - | 1779399..1779722 (+) | 324 | Protein_1724 | heavy metal translocating P-type ATPase | - |
| WOC69_RS08760 (WOC69_08760) | - | 1779779..1780453 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| WOC69_RS08765 (WOC69_08765) | - | 1780485..1780724 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| WOC69_RS08770 (WOC69_08770) | - | 1781139..1782395 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| WOC69_RS08775 (WOC69_08775) | - | 1783621..1785228 (-) | 1608 | Protein_1728 | heavy metal translocating P-type ATPase | - |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=971665 WOC69_RS08730 WP_001631036.1 1775541..1776902(-) (ccrA) [Staphylococcus aureus strain TUM22702]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=971665 WOC69_RS08730 WP_001631036.1 1775541..1776902(-) (ccrA) [Staphylococcus aureus strain TUM22702]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |