Detailed information NTG0968278

Bioinformatically predicted

Overview

• Name: letA
• Type: Regulator
• Locus tag: ACK2VW_RS10925
• Genome accession: NZ_CP176678
• Coordinates: 2210607..2211263 (+)
• Length: 218 a.a.
• NCBI ID: WP_000611335.1
• Uniprot ID: Q3Z2T8
• Organism: Escherichia coli O121 strain GTVSS-020
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2205607..2216263

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACK2VW_RS10890 (ACK2VW_10890)	dcyD	2206487..2207473 (+)	987	WP_001128215.1	D-cysteine desulfhydrase	-
ACK2VW_RS10895 (ACK2VW_10895)	tcyL	2207488..2208156 (+)	669	WP_001158220.1	cystine ABC transporter permease	-
ACK2VW_RS10900 (ACK2VW_10900)	tcyN	2208153..2208905 (+)	753	WP_001272994.1	L-cystine ABC transporter ATP-binding protein TcyN	-
ACK2VW_RS10905 (ACK2VW_10905)	sdiA	2209135..2209857 (+)	723	WP_001154267.1	transcriptional regulator SdiA	-
ACK2VW_RS10910 (ACK2VW_10910)	yecF	2209924..2210148 (-)	225	WP_000106474.1	DUF2594 family protein YecF	-
ACK2VW_RS10915 (ACK2VW_10915)	yecU	2210135..2210311 (-)	177	WP_000590344.1	protein YecU	-
ACK2VW_RS10920 (ACK2VW_10920)	-	2210349..2210465 (-)	117	WP_001302039.1	hypothetical protein	-
ACK2VW_RS10925 (ACK2VW_10925)	letA	2210607..2211263 (+)	657	WP_000611335.1	UvrY/SirA/GacA family response regulator transcription factor	Regulator
ACK2VW_RS10930 (ACK2VW_10930)	uvrC	2211260..2213092 (+)	1833	WP_001283421.1	excinuclease ABC subunit UvrC	Machinery gene
ACK2VW_RS10935 (ACK2VW_10935)	pgsA	2213149..2213697 (+)	549	WP_001160187.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-
ACK2VW_RS10955 (ACK2VW_10955)	-	2214692..2214973 (+)	282	WP_071529678.1	hypothetical protein	-
ACK2VW_RS10960 (ACK2VW_10960)	-	2215163..2215303 (-)	141	WP_000078920.1	Hok/Gef family protein	-
ACK2VW_RS10965 (ACK2VW_10965)	-	2215494..2215754 (-)	261	WP_000488108.1	ogr/Delta-like zinc finger family protein	-

Sequence

Protein

• Length: 218 a.a.
• Molecular weight: 23892.65 Da
• Isoelectric Point: 6.9614

>NTDB_id=968278 ACK2VW_RS10925 WP_000611335.1 2210607..2211263(+) (letA) [Escherichia coli O121 strain GTVSS-020]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide

• Length: 657 bp

>NTDB_id=968278 ACK2VW_RS10925 WP_000611335.1 2210607..2211263(+) (letA) [Escherichia coli O121 strain GTVSS-020]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCTAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-115)

• Bacterial regulatory proteins, luxR family (GerE) (149-204)

3D structure

• AlphaFold DB: Q3Z2T8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letA	Legionella pneumophila str. Paris	51.208	94.954	0.486
letA	Legionella pneumophila strain ERS1305867	51.208	94.954	0.486