Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   ACJ63U_RS09730 Genome accession   NZ_CP174453
Coordinates   2047204..2047860 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O25b:H4-ST131 strain MB1341     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2042204..2052860
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJ63U_RS09700 (ACJ63U_09700) dcyD 2043083..2044069 (+) 987 WP_001128232.1 D-cysteine desulfhydrase -
  ACJ63U_RS09705 (ACJ63U_09705) tcyL 2044084..2044752 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  ACJ63U_RS09710 (ACJ63U_09710) tcyN 2044749..2045501 (+) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  ACJ63U_RS09715 (ACJ63U_09715) sdiA 2045731..2046453 (+) 723 WP_001154255.1 transcriptional regulator SdiA -
  ACJ63U_RS09720 (ACJ63U_09720) yecF 2046521..2046745 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  ACJ63U_RS09725 (ACJ63U_09725) yecU 2046732..2046908 (-) 177 WP_001307856.1 protein YecU -
  ACJ63U_RS09730 (ACJ63U_09730) letA 2047204..2047860 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  ACJ63U_RS09735 (ACJ63U_09735) uvrC 2047857..2049689 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  ACJ63U_RS09740 (ACJ63U_09740) pgsA 2049746..2050294 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  ACJ63U_RS09760 (ACJ63U_09760) - 2050878..2051894 (-) 1017 WP_001531780.1 tyrosine-type recombinase/integrase -
  ACJ63U_RS09765 (ACJ63U_09765) - 2051863..2052126 (-) 264 WP_000833838.1 DUF4224 domain-containing protein -
  ACJ63U_RS09770 (ACJ63U_09770) - 2052336..2052518 (-) 183 WP_000916334.1 hypothetical protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=964990 ACJ63U_RS09730 WP_000611328.1 2047204..2047860(+) (letA) [Escherichia coli O25b:H4-ST131 strain MB1341]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=964990 ACJ63U_RS09730 WP_000611328.1 2047204..2047860(+) (letA) [Escherichia coli O25b:H4-ST131 strain MB1341]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482