Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   AAA995_RS05865 Genome accession   NZ_AP028877
Coordinates   1162182..1163531 (-) Length   449 a.a.
NCBI ID   WP_000886213.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 21P20     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1157182..1168531
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA995_RS05835 (SP21P20_11560) - 1157294..1158280 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  AAA995_RS05840 (SP21P20_11570) - 1158569..1159312 (-) 744 Protein_1154 ion channel -
  AAA995_RS05845 (SP21P20_11580) - 1159359..1159613 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  AAA995_RS05850 (SP21P20_11590) - 1159615..1159857 (-) 243 WP_000208080.1 DUF6290 family protein -
  AAA995_RS05855 (SP21P20_11600) - 1160051..1161307 (+) 1257 WP_000530083.1 ISL3 family transposase -
  AAA995_RS05860 (SP21P20_11610) vicX 1161371..1162180 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  AAA995_RS05865 (SP21P20_11620) micB 1162182..1163531 (-) 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK Regulator
  AAA995_RS05870 (SP21P20_11630) yycF 1163524..1164228 (-) 705 WP_000722076.1 response regulator YycF -
  AAA995_RS05875 (SP21P20_11640) mutY 1164284..1165459 (-) 1176 WP_000886152.1 A/G-specific adenine glycosylase -
  AAA995_RS05880 - 1165556..1165681 (+) 126 WP_001818232.1 hypothetical protein -
  AAA995_RS05885 (SP21P20_11650) - 1165787..1167457 (-) 1671 WP_000845285.1 formate--tetrahydrofolate ligase -
  AAA995_RS05890 (SP21P20_11660) coaB 1167687..1168376 (+) 690 WP_000699494.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51688.43 Da        Isoelectric Point: 4.9098

>NTDB_id=96493 AAA995_RS05865 WP_000886213.1 1162182..1163531(-) (micB) [Streptococcus pneumoniae strain 21P20]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSLLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=96493 AAA995_RS05865 WP_000886213.1 1162182..1163531(-) (micB) [Streptococcus pneumoniae strain 21P20]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAATGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGAGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCTCCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterProScan.

PAS fold (PAS)

(98-198)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.555

100

0.996
  vicK Streptococcus mutans UA159

69.652

89.532

0.624

Multiple sequence alignment