Detailed information NTG0962279

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: UXR22_RS10180
• Genome accession: NZ_CP149937
• Coordinates: 2043478..2044521 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN124
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2038478..2049521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UXR22_RS10150 (UXR22_10150)	-	2038896..2040152 (-)	1257	WP_001795438.1	aminopeptidase	-
UXR22_RS10155 (UXR22_10155)	-	2040155..2040355 (-)	201	WP_000180461.1	DUF1128 family protein	-
UXR22_RS10160 (UXR22_10160)	-	2040502..2040966 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
UXR22_RS10165 (UXR22_10165)	-	2040973..2041248 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
UXR22_RS10170 (UXR22_10170)	-	2041526..2042743 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
UXR22_RS10175 (UXR22_10175)	vraR	2042859..2043488 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
UXR22_RS10180 (UXR22_10180)	vraS	2043478..2044521 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
UXR22_RS10185 (UXR22_10185)	liaF	2044518..2045219 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
UXR22_RS10190 (UXR22_10190)	-	2045234..2045620 (-)	387	WP_001110179.1	hypothetical protein	-
UXR22_RS10195 (UXR22_10195)	map	2045837..2046595 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
UXR22_RS10200 (UXR22_10200)	-	2047123..2048109 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
UXR22_RS10205 (UXR22_10205)	-	2048599..2049012 (-)	414	WP_001549145.1	hypothetical protein	-
UXR22_RS10210 (UXR22_10210)	-	2049041..2049151 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=962279 UXR22_RS10180 WP_001017131.1 2043478..2044521(-) (vraS) [Staphylococcus aureus strain BSN124]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=962279 UXR22_RS10180 WP_001017131.1 2043478..2044521(-) (vraS) [Staphylococcus aureus strain BSN124]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1