Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   ACDK45_RS07675 Genome accession   NZ_CP167879
Coordinates   1531814..1533643 (-) Length   609 a.a.
NCBI ID   WP_011271801.1    Uniprot ID   Q4QPI7
Organism   Haemophilus influenzae strain NTHi52     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1526814..1538643
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACDK45_RS07655 (ACDK45_07655) - 1527800..1528828 (-) 1029 WP_005667996.1 zinc-binding dehydrogenase -
  ACDK45_RS07660 (ACDK45_07660) - 1528989..1529738 (+) 750 WP_044364992.1 GntR family transcriptional regulator -
  ACDK45_RS07665 (ACDK45_07665) uxuA 1529766..1530950 (+) 1185 WP_011271799.1 mannonate dehydratase -
  ACDK45_RS07670 (ACDK45_07670) - 1531003..1531716 (-) 714 WP_044364990.1 TerC family protein -
  ACDK45_RS07675 (ACDK45_07675) uvrC 1531814..1533643 (-) 1830 WP_011271801.1 excinuclease ABC subunit UvrC Machinery gene
  ACDK45_RS07680 (ACDK45_07680) kdsB 1533645..1534409 (-) 765 WP_005663240.1 3-deoxy-manno-octulosonate cytidylyltransferase -
  ACDK45_RS07685 (ACDK45_07685) lpxK 1534480..1535478 (-) 999 WP_011271802.1 tetraacyldisaccharide 4'-kinase -
  ACDK45_RS07690 (ACDK45_07690) msbA 1535551..1537314 (-) 1764 WP_011271803.1 lipid A ABC transporter ATP-binding protein/permease MsbA -

Sequence

Protein


Download         Length: 609 a.a.        Molecular weight: 69526.36 Da        Isoelectric Point: 9.0468

>NTDB_id=932586 ACDK45_RS07675 WP_011271801.1 1531814..1533643(-) (uvrC) [Haemophilus influenzae strain NTHi52]
MFDAKKFLADVSHEPGVYRMYDDKDQVIYVGKAKDLKKRLSSYFRKNLSSKKTEALVASIHHIDTMLTSSETEALLLEHN
FIKLYQPRYNVLLRDDKSYPFILLTKERHPRITSYRGSKKFAGEYFGPYPHAGAVRETLSLLQKLFPVRQCENSVYSNRS
RPCLQYQIGRCSAPCVQGYVSDEEYNQQVELARLFLQGKDQQVLDYLIGKMEQASRNLDFEQAARYRDQIQAVRSVIEKQ
FVSNERLDDMDIMSIAYQHGLACVQVMFIRQGKVLGNRSYFPKVPANTDLSELTETFVGQFYLQGHQGRSIPNSIIVDRQ
LAEKSELEQLLTEQAGRKVTIQESVKGDKSKYLQLAQVNAKAALNVQLKQSSRMSERYQALCDLLNLPEIKRMECFDISH
TMGNQTVASCVVFNQEGPLKSDYRRFNIEGITGGDDYAAMEQALQKRYERDLEEDKIPDIIFIDGGKGQLNRALNVFQHL
QVKWDKNRPHLIGVAKGVDRRAGQEVLIISKQDREIHLPDDSLALHLIQHIRDESHNHAISGHRKKRQKAFTQSGLETIE
GVGAKRRQALLKYLGGLQGVKKATLDEIASVPGISLKLAETIFETLKND

Nucleotide


Download         Length: 1830 bp        

>NTDB_id=932586 ACDK45_RS07675 WP_011271801.1 1531814..1533643(-) (uvrC) [Haemophilus influenzae strain NTHi52]
ATGTTTGATGCTAAAAAGTTCTTAGCGGATGTCTCTCACGAACCTGGTGTTTATCGTATGTATGACGATAAAGATCAGGT
TATTTATGTTGGGAAAGCAAAGGATCTAAAAAAACGTCTTTCAAGCTATTTTCGTAAAAATCTGAGTAGTAAAAAAACAG
AGGCGTTGGTAGCATCAATTCATCATATTGACACCATGCTAACTTCATCTGAAACGGAAGCTTTACTGCTAGAGCATAAT
TTTATCAAGCTTTATCAGCCTCGCTATAACGTATTATTGCGTGATGATAAATCCTATCCATTTATTTTATTAACCAAAGA
ACGCCATCCAAGAATCACGTCCTATCGTGGGTCTAAAAAATTTGCGGGTGAATATTTCGGCCCTTATCCTCACGCAGGCG
CCGTGCGTGAAACCTTATCGCTTTTACAAAAACTTTTCCCTGTTCGACAATGTGAAAATTCCGTTTATTCCAACCGCTCT
CGTCCTTGTTTACAATATCAAATTGGGCGTTGTTCTGCGCCTTGTGTACAGGGATATGTTTCCGATGAAGAATATAATCA
ACAAGTTGAATTAGCCCGTTTATTTTTACAAGGCAAAGATCAACAGGTGTTAGATTATTTAATCGGGAAAATGGAGCAGG
CAAGCAGAAATTTAGATTTTGAACAGGCGGCTCGTTATCGCGATCAAATTCAGGCGGTGCGTTCGGTTATTGAAAAACAA
TTTGTATCCAATGAACGTTTAGATGATATGGATATTATGTCCATCGCTTACCAACACGGTTTAGCCTGTGTACAAGTGAT
GTTTATTCGTCAAGGAAAAGTGCTAGGCAATCGCAGTTATTTCCCAAAAGTCCCTGCCAATACGGATTTATCGGAACTTA
CCGAAACTTTTGTGGGGCAATTTTATTTACAAGGTCATCAAGGGCGAAGTATCCCAAATAGTATTATTGTCGATCGTCAA
TTAGCTGAAAAATCAGAGCTTGAGCAACTTCTTACGGAGCAAGCAGGCAGAAAAGTGACGATTCAAGAAAGTGTAAAAGG
CGATAAGAGTAAATACTTACAGCTCGCACAAGTTAATGCTAAAGCGGCTTTAAATGTACAACTTAAACAATCTTCACGAA
TGTCAGAGCGTTATCAAGCGTTGTGTGATCTGTTAAATCTCCCTGAAATTAAGCGTATGGAGTGTTTCGATATAAGCCAC
ACGATGGGAAATCAAACGGTAGCATCTTGTGTTGTCTTTAATCAAGAAGGCCCACTGAAATCTGATTATCGTCGTTTTAA
TATTGAAGGCATTACTGGTGGGGATGATTATGCAGCAATGGAACAAGCGTTGCAGAAACGTTATGAGCGTGATTTAGAAG
AAGATAAAATTCCTGATATTATTTTTATTGATGGTGGAAAAGGGCAATTAAATCGTGCGCTGAACGTGTTCCAACATCTT
CAAGTAAAATGGGATAAAAATAGACCGCACTTAATTGGCGTGGCAAAAGGTGTGGATCGTCGAGCTGGGCAGGAAGTACT
GATCATCAGCAAACAAGACCGCGAAATTCATTTGCCTGATGATAGTTTGGCATTGCATTTGATTCAACACATCCGTGATG
AAAGTCATAATCACGCAATAAGCGGACACCGTAAAAAACGTCAAAAAGCCTTTACACAAAGTGGTTTAGAAACTATTGAA
GGTGTGGGCGCTAAACGTCGTCAGGCTTTACTGAAATATCTTGGCGGTTTACAAGGTGTGAAAAAGGCGACCTTAGATGA
AATAGCCTCTGTACCGGGAATTTCCCTTAAACTTGCTGAAACGATTTTTGAAACGCTCAAAAACGATTAA

Domains

Predicted by InterProScan.

Helix-hairpin-helix domain (HHH_5)

(556-607)

UvrB/uvrC motif (UVR)

(210-234)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(384-540)

GIY-YIG catalytic domain (GIY-YIG)

(15-90)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QPI7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

37.647

97.701

0.368
  uvrC Streptococcus pneumoniae R6

37.311

97.701

0.365
  uvrC Streptococcus pneumoniae D39

37.311

97.701

0.365