Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACB363_RS02505 Genome accession   NZ_CP167021
Coordinates   497846..498487 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain Isolate 5     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 492846..503487
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB363_RS02485 (ACB363_02485) - 493402..494142 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACB363_RS02490 (ACB363_02490) pknB 494139..496037 (+) 1899 WP_011018054.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB363_RS02495 (ACB363_02495) liaF 496160..496852 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ACB363_RS02500 (ACB363_02500) - 496849..497853 (+) 1005 WP_011528855.1 sensor histidine kinase -
  ACB363_RS02505 (ACB363_02505) vraR 497846..498487 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  ACB363_RS02510 (ACB363_02510) - 498524..499924 (+) 1401 WP_021299066.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB363_RS02515 (ACB363_02515) - 499924..500301 (+) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  ACB363_RS02520 (ACB363_02520) cysK 500319..501260 (-) 942 WP_011528853.1 cysteine synthase A -
  ACB363_RS02525 (ACB363_02525) - 501388..502020 (-) 633 WP_042769749.1 YigZ family protein -
  ACB363_RS02530 (ACB363_02530) comFA/cflA 502076..503401 (+) 1326 WP_011528851.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=931470 ACB363_RS02505 WP_002983671.1 497846..498487(+) (vraR) [Streptococcus pyogenes strain Isolate 5]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=931470 ACB363_RS02505 WP_002983671.1 497846..498487(+) (vraR) [Streptococcus pyogenes strain Isolate 5]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385