Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACB332_RS06250 Genome accession   NZ_CP167016
Coordinates   1249740..1250381 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain Isolate 10     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1244740..1255381
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB332_RS06225 (ACB332_06225) comFA/cflA 1244826..1246151 (-) 1326 WP_047235421.1 DEAD/DEAH box helicase Machinery gene
  ACB332_RS06230 (ACB332_06230) - 1246207..1246839 (+) 633 WP_002988970.1 YigZ family protein -
  ACB332_RS06235 (ACB332_06235) cysK 1246967..1247908 (+) 942 WP_011528853.1 cysteine synthase A -
  ACB332_RS06240 (ACB332_06240) - 1247926..1248303 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  ACB332_RS06245 (ACB332_06245) - 1248303..1249703 (-) 1401 WP_021775592.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB332_RS06250 (ACB332_06250) vraR 1249740..1250381 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  ACB332_RS06255 (ACB332_06255) - 1250374..1251378 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ACB332_RS06260 (ACB332_06260) liaF 1251375..1252067 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ACB332_RS06265 (ACB332_06265) pknB 1252190..1254088 (-) 1899 WP_063812253.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB332_RS06270 (ACB332_06270) - 1254085..1254825 (-) 741 WP_063812254.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=931024 ACB332_RS06250 WP_002983671.1 1249740..1250381(-) (vraR) [Streptococcus pyogenes strain Isolate 10]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=931024 ACB332_RS06250 WP_002983671.1 1249740..1250381(-) (vraR) [Streptococcus pyogenes strain Isolate 10]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385