Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACB355_RS07105 Genome accession   NZ_CP167011
Coordinates   1391697..1392338 (-) Length   213 a.a.
NCBI ID   WP_023079253.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 18     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1386697..1397338
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB355_RS07080 (ACB355_07080) comFA/cflA 1386783..1388108 (-) 1326 WP_115224631.1 DEAD/DEAH box helicase Machinery gene
  ACB355_RS07085 (ACB355_07085) - 1388164..1388796 (+) 633 WP_032465870.1 YigZ family protein -
  ACB355_RS07090 (ACB355_07090) cysK 1388924..1389865 (+) 942 WP_023079244.1 cysteine synthase A -
  ACB355_RS07095 (ACB355_07095) - 1389883..1390260 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  ACB355_RS07100 (ACB355_07100) - 1390260..1391660 (-) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB355_RS07105 (ACB355_07105) vraR 1391697..1392338 (-) 642 WP_023079253.1 response regulator transcription factor Regulator
  ACB355_RS07110 (ACB355_07110) - 1392331..1393335 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ACB355_RS07115 (ACB355_07115) liaF 1393332..1394024 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ACB355_RS07120 (ACB355_07120) pknB 1394147..1396045 (-) 1899 WP_023079250.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB355_RS07125 (ACB355_07125) - 1396042..1396782 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23781.46 Da        Isoelectric Point: 5.1641

>NTDB_id=930654 ACB355_RS07105 WP_023079253.1 1391697..1392338(-) (vraR) [Streptococcus pyogenes strain Isolate 18]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALTLKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=930654 ACB355_RS07105 WP_023079253.1 1391697..1392338(-) (vraR) [Streptococcus pyogenes strain Isolate 18]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGACTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385